Use the kNN algorithm to provide a classification of the data in the TBI case study, (CaseStudy11_TBI). Determine an appropriate k, train and evaluate the performance of the classification model on the data. Report some model quality statistics for a couple of different values of k and use these to rank-order (and perhaps plot the classification results of) the models.
library(readxl)
## Warning: package 'readxl' was built under R version 4.2.3
tbi<-read_excel("I:/UBD PB/ZH5102 ML/ass4/CaseStudy11_TBI.xlsx")
str(tbi)
## tibble [46 × 19] (S3: tbl_df/tbl/data.frame)
## $ id : num [1:46] 1 2 3 4 5 6 7 8 9 10 ...
## $ age : num [1:46] 19 55 24 57 54 16 21 25 30 38 ...
## $ sex : chr [1:46] "Male" "Male" "Male" "Female" ...
## $ mechanism : chr [1:46] "Fall" "Blunt" "Fall" "Fall" ...
## $ field.gcs : chr [1:46] "10" "." "12" "4" ...
## $ er.gcs : chr [1:46] "10" "3" "12" "4" ...
## $ icu.gcs : chr [1:46] "10" "3" "8" "6" ...
## $ worst.gcs : chr [1:46] "10" "3" "8" "4" ...
## $ 6m.gose : chr [1:46] "5" "5" "7" "3" ...
## $ 2013.gose : num [1:46] 5 7 7 3 7 8 3 3 5 3 ...
## $ skull.fx : num [1:46] 0 1 1 1 0 1 1 0 1 1 ...
## $ temp.injury: num [1:46] 1 1 0 1 1 1 0 1 1 1 ...
## $ surgery : num [1:46] 1 1 0 1 1 1 1 0 1 1 ...
## $ spikes.hr : chr [1:46] "." "168.74" "37.369999999999997" "4.3499999999999996" ...
## $ min.hr : chr [1:46] "." "14" "0" "0" ...
## $ max.hr : chr [1:46] "." "757" "351" "59" ...
## $ acute.sz : num [1:46] 1 0 0 0 0 0 0 0 0 0 ...
## $ late.sz : num [1:46] 1 1 0 0 0 1 0 1 1 1 ...
## $ ever.sz : num [1:46] 1 1 0 0 0 1 0 1 1 1 ...
tbi<-tbi[,-1]
tbi[tbi=="."] <- NA
tbi<- as.data.frame(tbi)
tbi$sex <- as.factor(tbi$sex)
tbi$mechanism <- as.factor(tbi$mechanism)
library(mi)
## Warning: package 'mi' was built under R version 4.2.3
## Loading required package: Matrix
## Loading required package: stats4
## mi (Version 1.1, packaged: 2022-06-05 05:31:15 UTC; ben)
## mi Copyright (C) 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015 Trustees of Columbia University
## This program comes with ABSOLUTELY NO WARRANTY.
## This is free software, and you are welcome to redistribute it
## under the General Public License version 2 or later.
## Execute RShowDoc('COPYING') for details.
tbic<-complete.cases(tbi)
prop.table(table(tbic))
## tbic
## FALSE TRUE
## 0.5 0.5
mdf<-missing_data.frame(tbi)
## NOTE: The following pairs of variables appear to have the same missingness pattern.
## Please verify whether they are in fact logically distinct variables.
## [,1] [,2]
## [1,] "icu.gcs" "worst.gcs"
head(mdf)
## age sex mechanism field.gcs er.gcs icu.gcs worst.gcs X6m.gose
## 1 19 Male Fall 10 10 10 10 5
## 2 55 Male Blunt <NA> 3 3 3 5
## 3 24 Male Fall 12 12 8 8 7
## 4 57 Female Fall 4 4 6 4 3
## 5 54 Female Peds_vs_Auto 14 11 8 8 5
## 6 16 Female MVA 13 7 7 7 7
## X2013.gose skull.fx temp.injury surgery spikes.hr min.hr max.hr
## 1 5 0 1 1 <NA> <NA> <NA>
## 2 7 1 1 1 168.74 14 757
## 3 7 1 0 0 37.369999999999997 0 351
## 4 3 1 1 1 4.3499999999999996 0 59
## 5 7 0 1 1 54.59 0 284
## 6 8 1 1 1 75.92 7 180
## acute.sz late.sz ever.sz missing_field.gcs missing_er.gcs missing_icu.gcs
## 1 1 1 1 FALSE FALSE FALSE
## 2 0 1 1 TRUE FALSE FALSE
## 3 0 0 0 FALSE FALSE FALSE
## 4 0 0 0 FALSE FALSE FALSE
## 5 0 0 0 FALSE FALSE FALSE
## 6 0 1 1 FALSE FALSE FALSE
## missing_worst.gcs missing_6m.gose missing_spikes.hr missing_min.hr
## 1 FALSE FALSE TRUE TRUE
## 2 FALSE FALSE FALSE FALSE
## 3 FALSE FALSE FALSE FALSE
## 4 FALSE FALSE FALSE FALSE
## 5 FALSE FALSE FALSE FALSE
## 6 FALSE FALSE FALSE FALSE
## missing_max.hr
## 1 TRUE
## 2 FALSE
## 3 FALSE
## 4 FALSE
## 5 FALSE
## 6 FALSE
show(mdf)
## Object of class missing_data.frame with 46 observations on 18 variables
##
## There are 7 missing data patterns
##
## Append '@patterns' to this missing_data.frame to access the corresponding pattern for every observation or perhaps use table()
##
## type missing method model
## age continuous 0 <NA> <NA>
## sex binary 0 <NA> <NA>
## mechanism unordered-categorical 0 <NA> <NA>
## field.gcs unordered-categorical 2 ppd mlogit
## er.gcs unordered-categorical 2 ppd mlogit
## icu.gcs unordered-categorical 1 ppd mlogit
## worst.gcs unordered-categorical 1 ppd mlogit
## 6m.gose unordered-categorical 5 ppd mlogit
## 2013.gose continuous 0 <NA> <NA>
## skull.fx binary 0 <NA> <NA>
## temp.injury binary 0 <NA> <NA>
## surgery binary 0 <NA> <NA>
## spikes.hr unordered-categorical 18 ppd mlogit
## min.hr unordered-categorical 18 ppd mlogit
## max.hr unordered-categorical 18 ppd mlogit
## acute.sz binary 0 <NA> <NA>
## late.sz binary 0 <NA> <NA>
## ever.sz binary 0 <NA> <NA>
##
## family link transformation
## age <NA> <NA> standardize
## sex <NA> <NA> <NA>
## mechanism <NA> <NA> <NA>
## field.gcs multinomial logit <NA>
## er.gcs multinomial logit <NA>
## icu.gcs multinomial logit <NA>
## worst.gcs multinomial logit <NA>
## 6m.gose multinomial logit <NA>
## 2013.gose <NA> <NA> standardize
## skull.fx <NA> <NA> <NA>
## temp.injury <NA> <NA> <NA>
## surgery <NA> <NA> <NA>
## spikes.hr multinomial logit <NA>
## min.hr multinomial logit <NA>
## max.hr multinomial logit <NA>
## acute.sz <NA> <NA> <NA>
## late.sz <NA> <NA> <NA>
## ever.sz <NA> <NA> <NA>
mdf<-change(mdf, y="field.gcs" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="er.gcs" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="icu.gcs" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="worst.gcs" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="6m.gose" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="min.hr" , what = "imputation_method", to="pmm")
mdf<-change(mdf, y="max.hr" , what = "imputation_method", to="pmm")
imputations<-mi(mdf, n.iter=1, n.chains=1, verbose=T)
tbim<- complete(imputations, 3)
tbim<-tbim[[1]]
tbim<-tbim[,-19:-26]
str(tbim)
## 'data.frame': 46 obs. of 18 variables:
## $ age : num 19 55 24 57 54 16 21 25 30 38 ...
## $ sex : Factor w/ 2 levels "Female","Male": 2 2 2 1 1 1 2 2 2 2 ...
## $ mechanism : Factor w/ 7 levels "Bike_vs_Auto",..: 3 2 3 3 7 6 3 3 4 3 ...
## $ field.gcs : Factor w/ 12 levels "10","12","13",..: 1 6 2 7 4 3 6 6 6 6 ...
## $ er.gcs : Factor w/ 13 levels "10","11","12",..: 1 7 3 8 2 11 7 8 13 10 ...
## $ icu.gcs : Factor w/ 11 levels "0","10","11",..: 2 6 10 8 10 9 8 6 6 8 ...
## $ worst.gcs : Factor w/ 13 levels "0","10","11",..: 2 7 12 8 12 11 7 7 7 7 ...
## $ X6m.gose : Factor w/ 7 levels "2","3","4","5",..: 4 4 6 2 4 6 2 2 2 2 ...
## $ X2013.gose : num 5 7 7 3 7 8 3 3 5 3 ...
## $ skull.fx : Factor w/ 2 levels "0","1": 1 2 2 2 1 2 2 1 2 2 ...
## $ temp.injury: Factor w/ 2 levels "0","1": 2 2 1 2 2 2 1 2 2 2 ...
## $ surgery : Factor w/ 2 levels "0","1": 2 2 1 2 2 2 2 1 2 2 ...
## $ spikes.hr : Factor w/ 28 levels "1.28","1.66",..: 21 4 12 13 20 26 17 17 14 15 ...
## $ min.hr : Factor w/ 7 levels "0","14","3","30",..: 1 2 1 1 1 7 1 1 1 5 ...
## $ max.hr : Factor w/ 28 levels "107","1199","12",..: 24 25 16 21 12 7 4 28 18 1 ...
## $ acute.sz : Factor w/ 2 levels "0","1": 2 1 1 1 1 1 1 1 1 1 ...
## $ late.sz : Factor w/ 2 levels "0","1": 2 2 1 1 1 2 1 2 2 2 ...
## $ ever.sz : Factor w/ 2 levels "0","1": 2 2 1 1 1 2 1 2 2 2 ...
library(dplyr)
##
## Attaching package: 'dplyr'
## The following objects are masked from 'package:stats':
##
## filter, lag
## The following objects are masked from 'package:base':
##
## intersect, setdiff, setequal, union
tbim<-tbim%>%mutate_at(c(2:8,10:18),as.integer)
Y <- ifelse (tbim$surgery == 1, "No","Yes")
X <- tbim[, -12]
t_train <- X[1:23, ]
t_test <- X[24:46, ]
t_train_labels <- Y[1:23]
t_test_labels <- Y[24:46]
table(t_train_labels)
## t_train_labels
## No Yes
## 7 16
round(prop.table(table(t_train_labels)), digits=2)
## t_train_labels
## No Yes
## 0.3 0.7
round(prop.table(table(t_test_labels)), digits=2)
## t_test_labels
## No Yes
## 0.43 0.57
library(class)
t_test_pred <- knn(train=t_train, test=t_test, cl=t_train_labels, k=3)
library(gmodels)
CT1<-CrossTable(x=t_test_labels, y=t_test_pred, prop.chisq = F);CT1
##
##
## Cell Contents
## |-------------------------|
## | N |
## | N / Row Total |
## | N / Col Total |
## | N / Table Total |
## |-------------------------|
##
##
## Total Observations in Table: 23
##
##
## | t_test_pred
## t_test_labels | No | Yes | Row Total |
## --------------|-----------|-----------|-----------|
## No | 3 | 7 | 10 |
## | 0.300 | 0.700 | 0.435 |
## | 0.333 | 0.500 | |
## | 0.130 | 0.304 | |
## --------------|-----------|-----------|-----------|
## Yes | 6 | 7 | 13 |
## | 0.462 | 0.538 | 0.565 |
## | 0.667 | 0.500 | |
## | 0.261 | 0.304 | |
## --------------|-----------|-----------|-----------|
## Column Total | 9 | 14 | 23 |
## | 0.391 | 0.609 | |
## --------------|-----------|-----------|-----------|
##
##
## $t
## y
## x No Yes
## No 3 7
## Yes 6 7
##
## $prop.row
## y
## x No Yes
## No 0.3000000 0.7000000
## Yes 0.4615385 0.5384615
##
## $prop.col
## y
## x No Yes
## No 0.3333333 0.5000000
## Yes 0.6666667 0.5000000
##
## $prop.tbl
## y
## x No Yes
## No 0.1304348 0.3043478
## Yes 0.2608696 0.3043478
print(paste0("Prediction accuracy of model 't_test_pred' (k=3) is ", (CT1$prop.tbl[1,1]+CT1$prop.tbl[2,2]) ))
## [1] "Prediction accuracy of model 't_test_pred' (k=3) is 0.434782608695652"
library(e1071)
knntuning = tune.knn(x= t_train, y = as.factor(t_train_labels), k = 1:20)
knntuning
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: 10-fold cross validation
##
## - best parameters:
## k
## 15
##
## - best performance: 0.3166667
summary(knntuning) # k=8
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: 10-fold cross validation
##
## - best parameters:
## k
## 15
##
## - best performance: 0.3166667
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.4833333 0.3464992
## 2 2 0.4666667 0.3406602
## 3 3 0.6333333 0.3583226
## 4 4 0.7333333 0.2960647
## 5 5 0.5000000 0.1924501
## 6 6 0.5500000 0.2490724
## 7 7 0.3666667 0.3122993
## 8 8 0.4666667 0.3406602
## 9 9 0.5000000 0.3042903
## 10 10 0.3666667 0.3122993
## 11 11 0.3666667 0.3122993
## 12 12 0.4666667 0.3406602
## 13 13 0.4000000 0.2854496
## 14 14 0.3666667 0.3122993
## 15 15 0.3166667 0.3282012
## 16 16 0.3166667 0.3282012
## 17 17 0.3166667 0.3282012
## 18 18 0.3166667 0.3282012
## 19 19 0.3166667 0.3282012
## 20 20 0.3166667 0.3282012
t_test_pred <- knn(train=t_train, test=t_test, cl=t_train_labels, prob=T, k=2)
t_test_predBin <- ifelse(attributes(t_test_pred)$prob >0.6, "No", "Yes")
CT2 <- CrossTable(x=t_test_labels, y=t_test_predBin, prop.chisq = F); CT2
##
##
## Cell Contents
## |-------------------------|
## | N |
## | N / Row Total |
## | N / Col Total |
## | N / Table Total |
## |-------------------------|
##
##
## Total Observations in Table: 23
##
##
## | t_test_predBin
## t_test_labels | No | Yes | Row Total |
## --------------|-----------|-----------|-----------|
## No | 3 | 7 | 10 |
## | 0.300 | 0.700 | 0.435 |
## | 0.333 | 0.500 | |
## | 0.130 | 0.304 | |
## --------------|-----------|-----------|-----------|
## Yes | 6 | 7 | 13 |
## | 0.462 | 0.538 | 0.565 |
## | 0.667 | 0.500 | |
## | 0.261 | 0.304 | |
## --------------|-----------|-----------|-----------|
## Column Total | 9 | 14 | 23 |
## | 0.391 | 0.609 | |
## --------------|-----------|-----------|-----------|
##
##
## $t
## y
## x No Yes
## No 3 7
## Yes 6 7
##
## $prop.row
## y
## x No Yes
## No 0.3000000 0.7000000
## Yes 0.4615385 0.5384615
##
## $prop.col
## y
## x No Yes
## No 0.3333333 0.5000000
## Yes 0.6666667 0.5000000
##
## $prop.tbl
## y
## x No Yes
## No 0.1304348 0.3043478
## Yes 0.2608696 0.3043478
print(paste0("Prediction accuracy of model 't_test_pred' (k=2) is ", (CT2$prop.tbl[1,1]+CT2$prop.tbl[2,2]) ))
## [1] "Prediction accuracy of model 't_test_pred' (k=2) is 0.434782608695652"
library(caret)
## Loading required package: ggplot2
## Loading required package: lattice
knnControl <- trainControl(
method = "cv", ## cross validation
number = 10, ## 10-fold
summaryFunction = twoClassSummary,
classProbs = TRUE,
verboseIter = FALSE
)
knn_model <- train(x=t_train, y=t_train_labels , metric = "ROC", method = "knn", tuneLength = 20, trControl = knnControl)
print(knn_model) # k = 13
## k-Nearest Neighbors
##
## 23 samples
## 17 predictors
## 2 classes: 'No', 'Yes'
##
## No pre-processing
## Resampling: Cross-Validated (10 fold)
## Summary of sample sizes: 21, 22, 22, 22, 20, 20, ...
## Resampling results across tuning parameters:
##
## k ROC Sens Spec
## 5 0.3928571 0.1428571 0.75
## 7 0.4285714 0.1428571 0.85
## 9 0.5000000 0.0000000 0.95
## 11 0.3928571 0.0000000 1.00
## 13 0.4642857 0.0000000 1.00
## 15 0.4285714 0.0000000 1.00
## 17 0.4285714 0.0000000 1.00
## 19 0.3571429 0.0000000 1.00
## 21 0.5000000 0.0000000 1.00
## 23 0.5000000 0.0000000 1.00
## 25 0.5000000 0.0000000 1.00
## 27 0.5000000 0.0000000 1.00
## 29 0.5000000 0.0000000 1.00
## 31 0.5000000 0.0000000 1.00
## 33 0.5000000 0.0000000 1.00
## 35 0.5000000 0.0000000 1.00
## 37 0.5000000 0.0000000 1.00
## 39 0.5000000 0.0000000 1.00
## 41 0.5000000 0.0000000 1.00
## 43 0.5000000 0.0000000 1.00
##
## ROC was used to select the optimal model using the largest value.
## The final value used for the model was k = 43.
t_test_pred <- knn(train=t_train, test=t_test, cl=t_train_labels, prob=T, k=9)
t_test_predBin <- ifelse(attributes(t_test_pred)$prob >0.6, "No", "Yes")
CT3 <- CrossTable(x=t_test_labels, y=t_test_predBin, prop.chisq = F); CT3
##
##
## Cell Contents
## |-------------------------|
## | N |
## | N / Row Total |
## | N / Col Total |
## | N / Table Total |
## |-------------------------|
##
##
## Total Observations in Table: 23
##
##
## | t_test_predBin
## t_test_labels | No | Yes | Row Total |
## --------------|-----------|-----------|-----------|
## No | 7 | 3 | 10 |
## | 0.700 | 0.300 | 0.435 |
## | 0.500 | 0.333 | |
## | 0.304 | 0.130 | |
## --------------|-----------|-----------|-----------|
## Yes | 7 | 6 | 13 |
## | 0.538 | 0.462 | 0.565 |
## | 0.500 | 0.667 | |
## | 0.304 | 0.261 | |
## --------------|-----------|-----------|-----------|
## Column Total | 14 | 9 | 23 |
## | 0.609 | 0.391 | |
## --------------|-----------|-----------|-----------|
##
##
## $t
## y
## x No Yes
## No 7 3
## Yes 7 6
##
## $prop.row
## y
## x No Yes
## No 0.7000000 0.3000000
## Yes 0.5384615 0.4615385
##
## $prop.col
## y
## x No Yes
## No 0.5000000 0.3333333
## Yes 0.5000000 0.6666667
##
## $prop.tbl
## y
## x No Yes
## No 0.3043478 0.1304348
## Yes 0.3043478 0.2608696
print(paste0("Prediction accuracy of model 't_test_pred' (k=9) is ", (CT3$prop.tbl[1,1]+CT2$prop.tbl[2,2]) ))
## [1] "Prediction accuracy of model 't_test_pred' (k=9) is 0.608695652173913"
library(dplyr)
summaryPredictions <- predict(knn_model, newdata = t_test, type = "prob")
summaryPredictionsLabel <- ifelse (summaryPredictions$No > 0.6, "No", "Yes")
testDataPredSummary <- as.data.frame(cbind(trueLabels=t_test_labels, YesProb=summaryPredictions$Yes,NoProb=summaryPredictions$No, knnPredLabel=summaryPredictionsLabel))
print(paste0("Accuracy = ", 2*as.numeric(table(testDataPredSummary$trueLabels == testDataPredSummary $knnPredLabel)[2]), "%"))
## [1] "Accuracy = 26%"
mod2_TN <- CT2$prop.row[1, 1]
mod2_FP <- CT2$prop.row[1, 2]
mod2_FN <- CT2$prop.row[2, 1]
mod2_TP <- CT2$prop.row[2, 2]
mod2_sensi <- mod2_TN/(mod2_TN+mod2_FP)
mod2_speci <- mod2_TP/(mod2_TP+mod2_FN)
print(paste0("kNN model k=2 Sensitivity=", mod2_sensi))
## [1] "kNN model k=2 Sensitivity=0.3"
print(paste0("kNN model k=2 Specificity=", mod2_speci))
## [1] "kNN model k=2 Specificity=0.538461538461538"
confusionMatrix(as.factor(t_test_labels), as.factor(t_test_predBin))
## Confusion Matrix and Statistics
##
## Reference
## Prediction No Yes
## No 7 3
## Yes 7 6
##
## Accuracy : 0.5652
## 95% CI : (0.3449, 0.7681)
## No Information Rate : 0.6087
## P-Value [Acc > NIR] : 0.7418
##
## Kappa : 0.1544
##
## Mcnemar's Test P-Value : 0.3428
##
## Sensitivity : 0.5000
## Specificity : 0.6667
## Pos Pred Value : 0.7000
## Neg Pred Value : 0.4615
## Prevalence : 0.6087
## Detection Rate : 0.3043
## Detection Prevalence : 0.4348
## Balanced Accuracy : 0.5833
##
## 'Positive' Class : No
##
library(plotly)
## Warning: package 'plotly' was built under R version 4.2.3
##
## Attaching package: 'plotly'
## The following object is masked from 'package:ggplot2':
##
## last_plot
## The following object is masked from 'package:stats':
##
## filter
## The following object is masked from 'package:graphics':
##
## layout
plot_ly(x = c("TN", "FN", "FP", "TP"),
y = c(mod2_TN, mod2_FN, mod2_FP, mod2_TP),
name = c("TN", "FN", "FP", "TP"), type = "bar", color=c("TN", "FN", "FP", "TP")) %>%
layout(title="Confusion Matrix",
legend=list(title=list(text='<b> Model k=2; Performance Metrics </b>')),
xaxis=list(title='Metrics'), yaxis=list(title='Probability'))
Use 05_PPMI_top_UPDRS_Integrated_LongFormat1 data to practice KNN classification.
ppmi<-read.csv("I:/UBD PB/ZH5102 ML/ass4/05_PPMI_top_UPDRS_Integrated_LongFormat.csv")
Preprocess the data: delete the
index and ID columns; convert the response
variable ResearchGroup to binary 0-1 factor; detect
NA (missing) values (impute if necessary)
ppmi$ctrl<-ifelse(ppmi$ResearchGroup=="Control", 1, 0)
ppmi$pd<-ifelse(ppmi$ResearchGroup=="PD", 1, 0)
ppmi$swedd<-ifelse(ppmi$ResearchGroup=="SWEDD", 1, 0)
ppmi<-ppmi[,-c(1:2,33,35)]
apply(is.na(ppmi), 2, which) ## No missing value
## integer(0)Summarize the dataset: use str,
summary, cor, ggpairs
str(ppmi)
## 'data.frame': 661 obs. of 70 variables:
## $ L_insular_cortex_ComputeArea : num 2918 2506 3285 2803 3189 ...
## $ L_insular_cortex_Volume : num 8754 8089 11446 9001 11004 ...
## $ R_insular_cortex_ComputeArea : num 2343 2074 2321 2225 2136 ...
## $ R_insular_cortex_Volume : num 5732 5321 6396 5567 5583 ...
## $ L_cingulate_gyrus_ComputeArea : num 4382 3222 4659 4017 4189 ...
## $ L_cingulate_gyrus_Volume : num 11205 7440 12444 9923 10502 ...
## $ R_cingulate_gyrus_ComputeArea : num 4610 3194 4028 3918 4352 ...
## $ R_cingulate_gyrus_Volume : num 12247 7265 9682 10227 11528 ...
## $ L_caudate_ComputeArea : num 622 877 1020 1087 863 ...
## $ L_caudate_Volume : num 822 1365 1570 1773 1341 ...
## $ R_caudate_ComputeArea : num 1302 1056 1209 1268 1247 ...
## $ R_caudate_Volume : num 2526 1965 2269 2263 2679 ...
## $ L_putamen_ComputeArea : num 1029 1276 1483 1050 1230 ...
## $ L_putamen_Volume : num 1543 2697 3046 2028 2483 ...
## $ R_putamen_ComputeArea : num 1680 1376 1311 1511 1299 ...
## $ R_putamen_Volume : num 3792 2967 2755 3459 2596 ...
## $ L_hippocampus_ComputeArea : num 1770 1530 1680 1552 1879 ...
## $ L_hippocampus_Volume : num 4737 3736 4458 3718 5079 ...
## $ R_hippocampus_ComputeArea : num 1579 1799 1850 1763 1977 ...
## $ R_hippocampus_Volume : num 3818 4665 5178 4529 5508 ...
## $ cerebellum_ComputeArea : num 20910 17627 15506 17130 17779 ...
## $ cerebellum_Volume : num 185743 155632 133879 141372 155221 ...
## $ L_fusiform_gyrus_ComputeArea : num 4535 4013 3903 4121 4864 ...
## $ L_fusiform_gyrus_Volume : num 15830 12678 11525 13775 17467 ...
## $ R_fusiform_gyrus_ComputeArea : num 3945 3552 4261 3920 5170 ...
## $ R_fusiform_gyrus_Volume : num 14472 11263 14214 14406 17455 ...
## $ R_fusiform_gyrus_ShapeIndex : num 0.359 0.333 0.352 0.349 0.386 ...
## $ R_fusiform_gyrus_Curvedness : num 0.0776 0.1099 0.0824 0.0902 0.0742 ...
## $ Sex : int 1 2 2 1 2 2 1 1 1 2 ...
## $ Weight : num 74.2 70.6 82 81.6 69.1 ...
## $ RG_ranked : int 2 2 2 0 2 0 2 0 2 0 ...
## $ Age : num 65.2 67.6 56.8 59.5 57.6 ...
## $ chr12_rs34637584_GT : int 0 0 0 0 0 0 0 0 0 0 ...
## $ chr17_rs11868035_GT : int 1 1 1 1 0 0 1 0 0 1 ...
## $ chr17_rs11012_GT : int 1 0 1 1 1 0 1 0 0 0 ...
## $ chr17_rs393152_GT : int 1 0 1 1 1 0 1 0 0 0 ...
## $ chr17_rs12185268_GT : int 1 0 1 1 1 0 1 1 0 0 ...
## $ chr17_rs199533_GT : int 0 0 1 1 1 0 1 1 0 0 ...
## $ UPDRS_Part_I_Summary_Score_Baseline : num 0 3 1 0 1 1 2 1 4 1 ...
## $ UPDRS_Part_I_Summary_Score_Month_03 : num 0 2 1 1.75 2 ...
## $ UPDRS_Part_I_Summary_Score_Month_06 : num 0 4.57 0 1.15 0 ...
## $ UPDRS_Part_I_Summary_Score_Month_09 : num 1 1 0 1.57 1 ...
## $ UPDRS_Part_I_Summary_Score_Month_12 : num 4 3 0 0 2 4 4 0 3 0 ...
## $ UPDRS_Part_I_Summary_Score_Month_18 : num 1 4 0.756 1.356 3.337 ...
## $ UPDRS_Part_I_Summary_Score_Month_24 : num 0 8 0 1 1.65 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline : num 2 15 6 0 4 2 11 0 6 2 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 : num 2 10 5 4.53 10 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 : num 3 12.42 3 6.12 10 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 : num 3 16 8 8.59 8 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 : num 3.00 1.50e+01 5.00 8.88e-16 1.30e+01 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 : num 4 16 9.23 4.69 16.33 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 : num 2.00 1.40e+01 7.00 8.88e-16 1.10e+01 ...
## $ UPDRS_Part_III_Summary_Score_Baseline : num 12 17 29 2 22 10 19 0 20 9 ...
## $ UPDRS_Part_III_Summary_Score_Month_03 : num 18 22 37 27.6 30 ...
## $ UPDRS_Part_III_Summary_Score_Month_06 : num 23 32.4 37 24.6 31 ...
## $ UPDRS_Part_III_Summary_Score_Month_09 : num 19 20 33 19.2 32 ...
## $ UPDRS_Part_III_Summary_Score_Month_12 : num 20 27 44 3 33 12 31 0 33 7 ...
## $ UPDRS_Part_III_Summary_Score_Month_18 : num 29 22 57.4 27.1 54.3 ...
## $ UPDRS_Part_III_Summary_Score_Month_24 : num 39 22 43 7 38.6 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline : num 6 14 8 6 0 4 2 2 7 6 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 : num 7 12.43 8 7.13 0 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 : num 3 14 6 6 6 6 6 5 8 3 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 : num 7 11 7 10 5.7 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline: int 6 6 4 5 5 5 6 4 5 6 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06: num 4 7.35 4 3.84 5 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12: num 5 6 4 4 5 5 4 4 7 5 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24: num 5 9 4 6 4.75 ...
## $ ctrl : num 0 0 0 1 0 1 0 1 0 1 ...
## $ pd : num 1 1 1 0 1 0 1 0 1 0 ...
## $ swedd : num 0 0 0 0 0 0 0 0 0 0 ...
summary(ppmi)
## L_insular_cortex_ComputeArea L_insular_cortex_Volume
## Min. : 50.03 Min. : 22.63
## 1st Qu.:1443.69 1st Qu.: 2750.06
## Median :2432.51 Median : 7027.40
## Mean :2133.98 Mean : 5985.29
## 3rd Qu.:2673.02 3rd Qu.: 8056.51
## Max. :4305.52 Max. :16533.59
## R_insular_cortex_ComputeArea R_insular_cortex_Volume
## Min. : 40.92 Min. : 11.84
## 1st Qu.: 980.24 1st Qu.:1496.82
## Median :1838.91 Median :4183.29
## Mean :1607.75 Mean :3621.89
## 3rd Qu.:2055.63 3rd Qu.:4888.80
## Max. :2791.92 Max. :8179.40
## L_cingulate_gyrus_ComputeArea L_cingulate_gyrus_Volume
## Min. : 127.8 Min. : 57.33
## 1st Qu.:1886.7 1st Qu.: 3074.95
## Median :3408.5 Median : 7981.12
## Mean :3066.2 Mean : 7125.75
## 3rd Qu.:3945.5 3rd Qu.: 9841.34
## Max. :5944.2 Max. :17153.19
## R_cingulate_gyrus_ComputeArea R_cingulate_gyrus_Volume L_caudate_ComputeArea
## Min. : 104.1 Min. : 47.67 Min. : 1.782
## 1st Qu.:1737.6 1st Qu.: 2677.14 1st Qu.: 205.938
## Median :3371.0 Median : 7880.86 Median : 609.675
## Mean :3000.1 Mean : 7024.79 Mean : 569.395
## 3rd Qu.:3993.4 3rd Qu.: 9948.56 3rd Qu.: 881.076
## Max. :6593.7 Max. :19761.77 Max. :1453.506
## L_caudate_Volume R_caudate_ComputeArea R_caudate_Volume
## Min. : 0.1928 Min. : 1.782 Min. : 0.193
## 1st Qu.: 121.3027 1st Qu.: 278.438 1st Qu.: 183.582
## Median : 771.5613 Median : 991.193 Median :1613.763
## Mean : 826.3136 Mean : 787.167 Mean :1316.809
## 3rd Qu.:1364.8601 3rd Qu.:1145.816 3rd Qu.:2034.239
## Max. :2746.6208 Max. :1684.563 Max. :3579.373
## L_putamen_ComputeArea L_putamen_Volume R_putamen_ComputeArea
## Min. : 6.76 Min. : 1.228 Min. : 13.93
## 1st Qu.: 470.71 1st Qu.: 445.284 1st Qu.: 736.90
## Median : 924.84 Median :1630.786 Median :1426.40
## Mean : 838.77 Mean :1534.120 Mean :1221.19
## 3rd Qu.:1117.64 3rd Qu.:2171.115 3rd Qu.:1591.24
## Max. :2500.30 Max. :4712.661 Max. :2251.41
## R_putamen_Volume L_hippocampus_ComputeArea L_hippocampus_Volume
## Min. : 3.207 Min. : 59.76 Min. : 25.48
## 1st Qu.:1065.902 1st Qu.: 845.90 1st Qu.:1364.06
## Median :3224.173 Median :1473.43 Median :3409.91
## Mean :2708.972 Mean :1299.27 Mean :2950.62
## 3rd Qu.:3823.152 3rd Qu.:1609.35 3rd Qu.:3973.02
## Max. :7096.580 Max. :3566.67 Max. :8978.26
## R_hippocampus_ComputeArea R_hippocampus_Volume cerebellum_ComputeArea
## Min. : 12.82 Min. : 3.709 Min. : 1963
## 1st Qu.:1079.88 1st Qu.: 1934.511 1st Qu.:15273
## Median :1634.02 Median : 4003.229 Median :16971
## Mean :1441.96 Mean : 3436.110 Mean :17103
## 3rd Qu.:1779.91 3rd Qu.: 4595.389 3rd Qu.:18881
## Max. :4247.85 Max. :13493.043 Max. :34238
## cerebellum_Volume L_fusiform_gyrus_ComputeArea L_fusiform_gyrus_Volume
## Min. : 6494 Min. : 363.7 Min. : 313.6
## 1st Qu.:124536 1st Qu.: 3079.7 1st Qu.: 8847.3
## Median :142639 Median : 3526.2 Median :10915.0
## Mean :140317 Mean : 3525.3 Mean :10548.3
## 3rd Qu.:158416 3rd Qu.: 3921.7 3rd Qu.:12803.5
## Max. :333820 Max. :11111.9 Max. :33615.1
## R_fusiform_gyrus_ComputeArea R_fusiform_gyrus_Volume
## Min. : 278 Min. : 171.2
## 1st Qu.:2933 1st Qu.: 8350.3
## Median :3357 Median :10510.7
## Mean :3355 Mean :10210.8
## 3rd Qu.:3781 3rd Qu.:12296.0
## Max. :9581 Max. :40579.4
## R_fusiform_gyrus_ShapeIndex R_fusiform_gyrus_Curvedness Sex
## Min. :0.2391 Min. :0.06633 Min. :1.000
## 1st Qu.:0.3110 1st Qu.:0.09098 1st Qu.:1.000
## Median :0.3282 Median :0.10061 Median :1.000
## Mean :0.3285 Mean :0.12088 Mean :1.342
## 3rd Qu.:0.3453 3rd Qu.:0.11269 3rd Qu.:2.000
## Max. :0.4754 Max. :3.66405 Max. :2.000
## Weight RG_ranked Age chr12_rs34637584_GT
## Min. : 43.20 Min. :0.000 Min. :31.18 Min. :0.000000
## 1st Qu.: 71.00 1st Qu.:0.000 1st Qu.:53.99 1st Qu.:0.000000
## Median : 81.10 Median :2.000 Median :62.22 Median :0.000000
## Mean : 82.17 Mean :1.405 Mean :61.28 Mean :0.009077
## 3rd Qu.: 90.90 3rd Qu.:2.000 3rd Qu.:68.91 3rd Qu.:0.000000
## Max. :139.60 Max. :2.000 Max. :83.42 Max. :1.000000
## chr17_rs11868035_GT chr17_rs11012_GT chr17_rs393152_GT chr17_rs12185268_GT
## Min. :0.0000 Min. :0.0000 Min. :0.00 Min. :0.0000
## 1st Qu.:0.0000 1st Qu.:0.0000 1st Qu.:0.00 1st Qu.:0.0000
## Median :0.0000 Median :0.0000 Median :0.00 Median :0.0000
## Mean :0.5976 Mean :0.3343 Mean :0.41 Mean :0.3858
## 3rd Qu.:1.0000 3rd Qu.:1.0000 3rd Qu.:1.00 3rd Qu.:1.0000
## Max. :2.0000 Max. :2.0000 Max. :2.00 Max. :2.0000
## chr17_rs199533_GT UPDRS_Part_I_Summary_Score_Baseline
## Min. :0.0000 Min. : 0.000
## 1st Qu.:0.0000 1st Qu.: 0.000
## Median :0.0000 Median : 1.000
## Mean :0.3737 Mean : 1.089
## 3rd Qu.:1.0000 3rd Qu.: 2.000
## Max. :2.0000 Max. :10.000
## UPDRS_Part_I_Summary_Score_Month_03 UPDRS_Part_I_Summary_Score_Month_06
## Min. :-1.213 Min. :-1.867
## 1st Qu.: 0.000 1st Qu.: 0.000
## Median : 1.000 Median : 1.000
## Mean : 1.431 Mean : 1.406
## 3rd Qu.: 2.000 3rd Qu.: 2.000
## Max. :11.000 Max. :11.000
## UPDRS_Part_I_Summary_Score_Month_09 UPDRS_Part_I_Summary_Score_Month_12
## Min. :-2.967 Min. :-1.689
## 1st Qu.: 0.000 1st Qu.: 0.000
## Median : 1.000 Median : 1.000
## Mean : 1.534 Mean : 1.308
## 3rd Qu.: 2.000 3rd Qu.: 2.000
## Max. :13.000 Max. :13.000
## UPDRS_Part_I_Summary_Score_Month_18 UPDRS_Part_I_Summary_Score_Month_24
## Min. :-0.9148 Min. :-2.368
## 1st Qu.: 0.0000 1st Qu.: 0.000
## Median : 1.0000 Median : 1.000
## Mean : 1.5321 Mean : 1.508
## 3rd Qu.: 2.0000 3rd Qu.: 2.000
## Max. :15.0000 Max. :13.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline
## Min. : 0.000
## 1st Qu.: 1.000
## Median : 3.000
## Mean : 4.532
## 3rd Qu.: 7.000
## Max. :25.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03
## Min. :-9.156
## 1st Qu.: 3.000
## Median : 5.000
## Mean : 6.257
## 3rd Qu.: 8.000
## Max. :25.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06
## Min. :-2.094
## 1st Qu.: 3.059
## Median : 5.166
## Mean : 6.228
## 3rd Qu.: 8.000
## Max. :28.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09
## Min. :-3.409
## 1st Qu.: 4.000
## Median : 6.417
## Mean : 7.344
## 3rd Qu.: 9.315
## Max. :28.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12
## Min. :-3.436
## 1st Qu.: 1.000
## Median : 4.000
## Mean : 5.591
## 3rd Qu.: 9.000
## Max. :29.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18
## Min. :-2.139
## 1st Qu.: 4.000
## Median : 6.000
## Mean : 7.346
## 3rd Qu.:10.000
## Max. :26.000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24
## Min. :-3.191
## 1st Qu.: 1.000
## Median : 5.000
## Mean : 6.144
## 3rd Qu.:10.000
## Max. :39.000
## UPDRS_Part_III_Summary_Score_Baseline UPDRS_Part_III_Summary_Score_Month_03
## Min. : 0 Min. : 0.00
## 1st Qu.: 4 1st Qu.:17.00
## Median :16 Median :22.00
## Mean :16 Mean :22.42
## 3rd Qu.:24 3rd Qu.:28.00
## Max. :47 Max. :59.00
## UPDRS_Part_III_Summary_Score_Month_06 UPDRS_Part_III_Summary_Score_Month_09
## Min. : 0.00 Min. :-5.689
## 1st Qu.:15.06 1st Qu.:12.000
## Median :22.00 Median :18.000
## Mean :22.70 Mean :20.727
## 3rd Qu.:28.00 3rd Qu.:28.000
## Max. :56.00 Max. :61.000
## UPDRS_Part_III_Summary_Score_Month_12 UPDRS_Part_III_Summary_Score_Month_18
## Min. :-7.135 Min. : 2.00
## 1st Qu.: 5.000 1st Qu.:17.00
## Median :18.000 Median :22.00
## Mean :17.593 Mean :23.76
## 3rd Qu.:27.000 3rd Qu.:30.00
## Max. :56.000 Max. :74.00
## UPDRS_Part_III_Summary_Score_Month_24
## Min. :-4.757
## 1st Qu.: 6.000
## Median :20.000
## Mean :19.450
## 3rd Qu.:30.000
## Max. :69.000
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline
## Min. : 0.000
## 1st Qu.: 3.000
## Median : 6.000
## Mean : 6.131
## 3rd Qu.: 8.000
## Max. :19.000
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06
## Min. :-1.315
## 1st Qu.: 4.000
## Median : 6.000
## Mean : 6.483
## 3rd Qu.: 8.743
## Max. :20.774
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12
## Min. : 0.00
## 1st Qu.: 3.00
## Median : 6.00
## Mean : 6.28
## 3rd Qu.: 9.00
## Max. :21.00
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24
## Min. :-1.918
## 1st Qu.: 4.000
## Median : 6.000
## Mean : 6.799
## 3rd Qu.:10.000
## Max. :22.000
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline
## Min. : 1.000
## 1st Qu.: 5.000
## Median : 5.000
## Mean : 5.244
## 3rd Qu.: 6.000
## Max. :15.000
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06
## Min. : 1.000
## 1st Qu.: 4.000
## Median : 5.000
## Mean : 5.017
## 3rd Qu.: 5.957
## Max. :10.583
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12
## Min. : 1.000
## 1st Qu.: 4.000
## Median : 5.000
## Mean : 5.079
## 3rd Qu.: 6.000
## Max. :14.000
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24
## Min. : 1.000
## 1st Qu.: 5.000
## Median : 5.000
## Mean : 5.411
## 3rd Qu.: 6.000
## Max. :15.000
## ctrl pd swedd
## Min. :0.0000 Min. :0.0000 Min. :0.00000
## 1st Qu.:0.0000 1st Qu.:0.0000 1st Qu.:0.00000
## Median :0.0000 Median :1.0000 Median :0.00000
## Mean :0.2511 Mean :0.6566 Mean :0.09228
## 3rd Qu.:1.0000 3rd Qu.:1.0000 3rd Qu.:0.00000
## Max. :1.0000 Max. :1.0000 Max. :1.00000
head(cor(ppmi))
## L_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 1.0000000
## L_insular_cortex_Volume 0.9869107
## R_insular_cortex_ComputeArea 0.9342669
## R_insular_cortex_Volume 0.9223210
## L_cingulate_gyrus_ComputeArea 0.9066181
## L_cingulate_gyrus_Volume 0.8950167
## L_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.9869107
## L_insular_cortex_Volume 1.0000000
## R_insular_cortex_ComputeArea 0.9312231
## R_insular_cortex_Volume 0.9340757
## L_cingulate_gyrus_ComputeArea 0.9064426
## L_cingulate_gyrus_Volume 0.9061706
## R_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.9342669
## L_insular_cortex_Volume 0.9312231
## R_insular_cortex_ComputeArea 1.0000000
## R_insular_cortex_Volume 0.9864854
## L_cingulate_gyrus_ComputeArea 0.9198314
## L_cingulate_gyrus_Volume 0.9112576
## R_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.9223210
## L_insular_cortex_Volume 0.9340757
## R_insular_cortex_ComputeArea 0.9864854
## R_insular_cortex_Volume 1.0000000
## L_cingulate_gyrus_ComputeArea 0.9128562
## L_cingulate_gyrus_Volume 0.9173129
## L_cingulate_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.9066181
## L_insular_cortex_Volume 0.9064426
## R_insular_cortex_ComputeArea 0.9198314
## R_insular_cortex_Volume 0.9128562
## L_cingulate_gyrus_ComputeArea 1.0000000
## L_cingulate_gyrus_Volume 0.9890268
## L_cingulate_gyrus_Volume
## L_insular_cortex_ComputeArea 0.8950167
## L_insular_cortex_Volume 0.9061706
## R_insular_cortex_ComputeArea 0.9112576
## R_insular_cortex_Volume 0.9173129
## L_cingulate_gyrus_ComputeArea 0.9890268
## L_cingulate_gyrus_Volume 1.0000000
## R_cingulate_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.8786873
## L_insular_cortex_Volume 0.8726901
## R_insular_cortex_ComputeArea 0.9001134
## R_insular_cortex_Volume 0.8800499
## L_cingulate_gyrus_ComputeArea 0.9553278
## L_cingulate_gyrus_Volume 0.9425262
## R_cingulate_gyrus_Volume L_caudate_ComputeArea
## L_insular_cortex_ComputeArea 0.8681304 0.7801791
## L_insular_cortex_Volume 0.8702824 0.8027567
## R_insular_cortex_ComputeArea 0.8877989 0.8096193
## R_insular_cortex_Volume 0.8752513 0.8382612
## L_cingulate_gyrus_ComputeArea 0.9460036 0.7850613
## L_cingulate_gyrus_Volume 0.9484323 0.7902421
## L_caudate_Volume R_caudate_ComputeArea
## L_insular_cortex_ComputeArea 0.7356630 0.8726696
## L_insular_cortex_Volume 0.7684050 0.8763832
## R_insular_cortex_ComputeArea 0.7672972 0.8999858
## R_insular_cortex_Volume 0.8082229 0.8898095
## L_cingulate_gyrus_ComputeArea 0.7474220 0.8803500
## L_cingulate_gyrus_Volume 0.7600546 0.8804745
## R_caudate_Volume L_putamen_ComputeArea
## L_insular_cortex_ComputeArea 0.8465954 0.8065258
## L_insular_cortex_Volume 0.8611024 0.8158911
## R_insular_cortex_ComputeArea 0.8743784 0.8104844
## R_insular_cortex_Volume 0.8755144 0.8204105
## L_cingulate_gyrus_ComputeArea 0.8719110 0.8251934
## L_cingulate_gyrus_Volume 0.8798692 0.8209777
## L_putamen_Volume R_putamen_ComputeArea
## L_insular_cortex_ComputeArea 0.7983473 0.8630235
## L_insular_cortex_Volume 0.8212568 0.8550263
## R_insular_cortex_ComputeArea 0.8122697 0.8781610
## R_insular_cortex_Volume 0.8372853 0.8625389
## L_cingulate_gyrus_ComputeArea 0.8305803 0.8646889
## L_cingulate_gyrus_Volume 0.8381930 0.8576840
## R_putamen_Volume L_hippocampus_ComputeArea
## L_insular_cortex_ComputeArea 0.8656614 0.8597525
## L_insular_cortex_Volume 0.8680120 0.8440409
## R_insular_cortex_ComputeArea 0.8885475 0.8648806
## R_insular_cortex_Volume 0.8823012 0.8453417
## L_cingulate_gyrus_ComputeArea 0.8815889 0.8169488
## L_cingulate_gyrus_Volume 0.8854569 0.8127096
## L_hippocampus_Volume R_hippocampus_ComputeArea
## L_insular_cortex_ComputeArea 0.8680771 0.7977111
## L_insular_cortex_Volume 0.8633996 0.7746534
## R_insular_cortex_ComputeArea 0.8750524 0.8307009
## R_insular_cortex_Volume 0.8648499 0.7984671
## L_cingulate_gyrus_ComputeArea 0.8332719 0.7433216
## L_cingulate_gyrus_Volume 0.8360487 0.7363470
## R_hippocampus_Volume cerebellum_ComputeArea
## L_insular_cortex_ComputeArea 0.8107977 0.083094545
## L_insular_cortex_Volume 0.7927911 0.045660307
## R_insular_cortex_ComputeArea 0.8339924 0.026027081
## R_insular_cortex_Volume 0.8072580 -0.001161312
## L_cingulate_gyrus_ComputeArea 0.7574599 0.029993537
## L_cingulate_gyrus_Volume 0.7543313 -0.001830579
## cerebellum_Volume L_fusiform_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.2541031 0.2561303
## L_insular_cortex_Volume 0.2221619 0.2165953
## R_insular_cortex_ComputeArea 0.2170924 0.2465034
## R_insular_cortex_Volume 0.1946481 0.2070348
## L_cingulate_gyrus_ComputeArea 0.1903846 0.2724242
## L_cingulate_gyrus_Volume 0.1688171 0.2346300
## L_fusiform_gyrus_Volume
## L_insular_cortex_ComputeArea 0.5530243
## L_insular_cortex_Volume 0.5237187
## R_insular_cortex_ComputeArea 0.5489204
## R_insular_cortex_Volume 0.5137358
## L_cingulate_gyrus_ComputeArea 0.5475110
## L_cingulate_gyrus_Volume 0.5234031
## R_fusiform_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.3237856
## L_insular_cortex_Volume 0.3004413
## R_insular_cortex_ComputeArea 0.3501993
## R_insular_cortex_Volume 0.3286232
## L_cingulate_gyrus_ComputeArea 0.3344158
## L_cingulate_gyrus_Volume 0.3137510
## R_fusiform_gyrus_Volume
## L_insular_cortex_ComputeArea 0.5207982
## L_insular_cortex_Volume 0.5083254
## R_insular_cortex_ComputeArea 0.5491854
## R_insular_cortex_Volume 0.5341228
## L_cingulate_gyrus_ComputeArea 0.5221324
## L_cingulate_gyrus_Volume 0.5152157
## R_fusiform_gyrus_ShapeIndex
## L_insular_cortex_ComputeArea 0.1378931
## L_insular_cortex_Volume 0.1219627
## R_insular_cortex_ComputeArea 0.1678356
## R_insular_cortex_Volume 0.1532675
## L_cingulate_gyrus_ComputeArea 0.1569564
## L_cingulate_gyrus_Volume 0.1486009
## R_fusiform_gyrus_Curvedness Sex
## L_insular_cortex_ComputeArea -0.09476000 -0.0062132767
## L_insular_cortex_Volume -0.08883770 -0.0053626323
## R_insular_cortex_ComputeArea -0.09127449 0.0100477270
## R_insular_cortex_Volume -0.09509853 0.0002929813
## L_cingulate_gyrus_ComputeArea -0.09908251 0.0129937704
## L_cingulate_gyrus_Volume -0.09635133 -0.0090989093
## Weight RG_ranked Age
## L_insular_cortex_ComputeArea -0.04999301 0.09239759 -0.1604988
## L_insular_cortex_Volume -0.04535880 0.09503603 -0.1658022
## R_insular_cortex_ComputeArea -0.05059769 0.12348639 -0.1722773
## R_insular_cortex_Volume -0.04230132 0.12676181 -0.1900328
## L_cingulate_gyrus_ComputeArea -0.03061862 0.10333186 -0.1348192
## L_cingulate_gyrus_Volume -0.01611345 0.10323303 -0.1276124
## chr12_rs34637584_GT chr17_rs11868035_GT
## L_insular_cortex_ComputeArea 0.02313389 0.03180370
## L_insular_cortex_Volume 0.02787306 0.04388073
## R_insular_cortex_ComputeArea 0.05171132 0.03898593
## R_insular_cortex_Volume 0.04537215 0.04917252
## L_cingulate_gyrus_ComputeArea 0.02033654 0.05162351
## L_cingulate_gyrus_Volume 0.01739230 0.05606594
## chr17_rs11012_GT chr17_rs393152_GT
## L_insular_cortex_ComputeArea 0.02021830 0.04489629
## L_insular_cortex_Volume 0.01924977 0.04174185
## R_insular_cortex_ComputeArea 0.02363442 0.04333337
## R_insular_cortex_Volume 0.02604213 0.04453367
## L_cingulate_gyrus_ComputeArea 0.02078362 0.03904277
## L_cingulate_gyrus_Volume 0.02721221 0.03920510
## chr17_rs12185268_GT chr17_rs199533_GT
## L_insular_cortex_ComputeArea 0.04189441 0.02370971
## L_insular_cortex_Volume 0.04427836 0.02003913
## R_insular_cortex_ComputeArea 0.03877958 0.03426735
## R_insular_cortex_Volume 0.04290497 0.03467802
## L_cingulate_gyrus_ComputeArea 0.03897924 0.02627749
## L_cingulate_gyrus_Volume 0.04060537 0.02425898
## UPDRS_Part_I_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.0093886187
## L_insular_cortex_Volume -0.0157087025
## R_insular_cortex_ComputeArea 0.0021367683
## R_insular_cortex_Volume -0.0182229000
## L_cingulate_gyrus_ComputeArea 0.0182209149
## L_cingulate_gyrus_Volume -0.0002518723
## UPDRS_Part_I_Summary_Score_Month_03
## L_insular_cortex_ComputeArea -0.012472099
## L_insular_cortex_Volume -0.010337450
## R_insular_cortex_ComputeArea 0.010006783
## R_insular_cortex_Volume 0.005925924
## L_cingulate_gyrus_ComputeArea 0.015877080
## L_cingulate_gyrus_Volume 0.011514224
## UPDRS_Part_I_Summary_Score_Month_06
## L_insular_cortex_ComputeArea -0.07928788
## L_insular_cortex_Volume -0.07651975
## R_insular_cortex_ComputeArea -0.06295411
## R_insular_cortex_Volume -0.06770069
## L_cingulate_gyrus_ComputeArea -0.04213690
## L_cingulate_gyrus_Volume -0.05777188
## UPDRS_Part_I_Summary_Score_Month_09
## L_insular_cortex_ComputeArea -0.05501857
## L_insular_cortex_Volume -0.05583489
## R_insular_cortex_ComputeArea -0.05325644
## R_insular_cortex_Volume -0.06325936
## L_cingulate_gyrus_ComputeArea -0.03626255
## L_cingulate_gyrus_Volume -0.04859476
## UPDRS_Part_I_Summary_Score_Month_12
## L_insular_cortex_ComputeArea -0.05967940
## L_insular_cortex_Volume -0.05669029
## R_insular_cortex_ComputeArea -0.05448326
## R_insular_cortex_Volume -0.06243407
## L_cingulate_gyrus_ComputeArea -0.03472733
## L_cingulate_gyrus_Volume -0.04839314
## UPDRS_Part_I_Summary_Score_Month_18
## L_insular_cortex_ComputeArea -0.04869355
## L_insular_cortex_Volume -0.04533515
## R_insular_cortex_ComputeArea -0.04665195
## R_insular_cortex_Volume -0.05717017
## L_cingulate_gyrus_ComputeArea -0.02343014
## L_cingulate_gyrus_Volume -0.03801463
## UPDRS_Part_I_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.05138547
## L_insular_cortex_Volume -0.05209003
## R_insular_cortex_ComputeArea -0.04274187
## R_insular_cortex_Volume -0.05638882
## L_cingulate_gyrus_ComputeArea -0.01853608
## L_cingulate_gyrus_Volume -0.03736066
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline
## L_insular_cortex_ComputeArea 0.05321904
## L_insular_cortex_Volume 0.05761923
## R_insular_cortex_ComputeArea 0.07182889
## R_insular_cortex_Volume 0.06900175
## L_cingulate_gyrus_ComputeArea 0.06324164
## L_cingulate_gyrus_Volume 0.05638850
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03
## L_insular_cortex_ComputeArea 0.02801793
## L_insular_cortex_Volume 0.03307860
## R_insular_cortex_ComputeArea 0.03339054
## R_insular_cortex_Volume 0.03677451
## L_cingulate_gyrus_ComputeArea 0.03713266
## L_cingulate_gyrus_Volume 0.03481756
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.0083358852
## L_insular_cortex_Volume 0.0110432640
## R_insular_cortex_ComputeArea 0.0122405147
## R_insular_cortex_Volume 0.0097541144
## L_cingulate_gyrus_ComputeArea 0.0081098836
## L_cingulate_gyrus_Volume -0.0005230219
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09
## L_insular_cortex_ComputeArea -0.015885827
## L_insular_cortex_Volume -0.011651035
## R_insular_cortex_ComputeArea -0.008240799
## R_insular_cortex_Volume -0.008684586
## L_cingulate_gyrus_ComputeArea 0.004341199
## L_cingulate_gyrus_Volume -0.003036511
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 0.01252248
## L_insular_cortex_Volume 0.01833548
## R_insular_cortex_ComputeArea 0.02507236
## R_insular_cortex_Volume 0.02629474
## L_cingulate_gyrus_ComputeArea 0.02774204
## L_cingulate_gyrus_Volume 0.02168495
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18
## L_insular_cortex_ComputeArea 0.02628717
## L_insular_cortex_Volume 0.03061579
## R_insular_cortex_ComputeArea 0.01763355
## R_insular_cortex_Volume 0.01439548
## L_cingulate_gyrus_ComputeArea 0.02752759
## L_cingulate_gyrus_Volume 0.02016424
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24
## L_insular_cortex_ComputeArea 0.02279844
## L_insular_cortex_Volume 0.02547553
## R_insular_cortex_ComputeArea 0.03463902
## R_insular_cortex_Volume 0.03072883
## L_cingulate_gyrus_ComputeArea 0.05255544
## L_cingulate_gyrus_Volume 0.04590150
## UPDRS_Part_III_Summary_Score_Baseline
## L_insular_cortex_ComputeArea 0.04055237
## L_insular_cortex_Volume 0.03834464
## R_insular_cortex_ComputeArea 0.06492683
## R_insular_cortex_Volume 0.05517909
## L_cingulate_gyrus_ComputeArea 0.07637809
## L_cingulate_gyrus_Volume 0.07326427
## UPDRS_Part_III_Summary_Score_Month_03
## L_insular_cortex_ComputeArea 0.010983120
## L_insular_cortex_Volume 0.005255359
## R_insular_cortex_ComputeArea 0.015031436
## R_insular_cortex_Volume 0.010763637
## L_cingulate_gyrus_ComputeArea 0.046565941
## L_cingulate_gyrus_Volume 0.043037799
## UPDRS_Part_III_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.01973977
## L_insular_cortex_Volume 0.01207100
## R_insular_cortex_ComputeArea 0.03879313
## R_insular_cortex_Volume 0.03045534
## L_cingulate_gyrus_ComputeArea 0.06063979
## L_cingulate_gyrus_Volume 0.05312402
## UPDRS_Part_III_Summary_Score_Month_09
## L_insular_cortex_ComputeArea 0.02138912
## L_insular_cortex_Volume 0.02172579
## R_insular_cortex_ComputeArea 0.03361453
## R_insular_cortex_Volume 0.02931567
## L_cingulate_gyrus_ComputeArea 0.07629590
## L_cingulate_gyrus_Volume 0.06879417
## UPDRS_Part_III_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 0.07148694
## L_insular_cortex_Volume 0.07713916
## R_insular_cortex_ComputeArea 0.09431129
## R_insular_cortex_Volume 0.09519589
## L_cingulate_gyrus_ComputeArea 0.11658384
## L_cingulate_gyrus_Volume 0.11104347
## UPDRS_Part_III_Summary_Score_Month_18
## L_insular_cortex_ComputeArea 0.05336178
## L_insular_cortex_Volume 0.06074224
## R_insular_cortex_ComputeArea 0.05543650
## R_insular_cortex_Volume 0.05961615
## L_cingulate_gyrus_ComputeArea 0.11857211
## L_cingulate_gyrus_Volume 0.11829250
## UPDRS_Part_III_Summary_Score_Month_24
## L_insular_cortex_ComputeArea 0.06011569
## L_insular_cortex_Volume 0.06171122
## R_insular_cortex_ComputeArea 0.07867912
## R_insular_cortex_Volume 0.07746319
## L_cingulate_gyrus_ComputeArea 0.10302806
## L_cingulate_gyrus_Volume 0.09834521
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.05447329
## L_insular_cortex_Volume -0.05968219
## R_insular_cortex_ComputeArea -0.05693927
## R_insular_cortex_Volume -0.07100614
## L_cingulate_gyrus_ComputeArea -0.05383286
## L_cingulate_gyrus_Volume -0.06761808
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06
## L_insular_cortex_ComputeArea -0.05709074
## L_insular_cortex_Volume -0.06868719
## R_insular_cortex_ComputeArea -0.07562573
## R_insular_cortex_Volume -0.08843075
## L_cingulate_gyrus_ComputeArea -0.05682046
## L_cingulate_gyrus_Volume -0.07658757
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12
## L_insular_cortex_ComputeArea -0.08271529
## L_insular_cortex_Volume -0.08381688
## R_insular_cortex_ComputeArea -0.08353771
## R_insular_cortex_Volume -0.09165303
## L_cingulate_gyrus_ComputeArea -0.06569288
## L_cingulate_gyrus_Volume -0.07691541
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.02117213
## L_insular_cortex_Volume -0.02728178
## R_insular_cortex_ComputeArea -0.02667260
## R_insular_cortex_Volume -0.03913104
## L_cingulate_gyrus_ComputeArea -0.01592867
## L_cingulate_gyrus_Volume -0.02428669
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.04207489
## L_insular_cortex_Volume -0.03900997
## R_insular_cortex_ComputeArea -0.02606728
## R_insular_cortex_Volume -0.03593653
## L_cingulate_gyrus_ComputeArea -0.02312798
## L_cingulate_gyrus_Volume -0.03323586
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.01194460
## L_insular_cortex_Volume 0.01076127
## R_insular_cortex_ComputeArea 0.02179706
## R_insular_cortex_Volume 0.01223188
## L_cingulate_gyrus_ComputeArea 0.03052371
## L_cingulate_gyrus_Volume 0.01670597
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 0.01701324
## L_insular_cortex_Volume 0.01343028
## R_insular_cortex_ComputeArea 0.02213299
## R_insular_cortex_Volume 0.01247332
## L_cingulate_gyrus_ComputeArea 0.04155994
## L_cingulate_gyrus_Volume 0.02904163
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.025708869
## L_insular_cortex_Volume -0.033327529
## R_insular_cortex_ComputeArea 0.011445722
## R_insular_cortex_Volume -0.000919461
## L_cingulate_gyrus_ComputeArea -0.004241417
## L_cingulate_gyrus_Volume -0.010476478
## ctrl pd swedd
## L_insular_cortex_ComputeArea -0.05840621 0.1144219 -0.10021330
## L_insular_cortex_Volume -0.06091647 0.1169198 -0.10055033
## R_insular_cortex_ComputeArea -0.08782920 0.1439974 -0.10465029
## R_insular_cortex_Volume -0.08905956 0.1488208 -0.11072031
## L_cingulate_gyrus_ComputeArea -0.07251633 0.1213884 -0.09050100
## L_cingulate_gyrus_Volume -0.06958890 0.1238825 -0.09897927
library(GGally)
## Warning: package 'GGally' was built under R version 4.2.3
## Registered S3 method overwritten by 'GGally':
## method from
## +.gg ggplot2
ggpairs(ppmi, columns = 1:5, ggplot2::aes(colour=as.factor(pd)))
Scale/Normalize the data: As appropriate, scale to 0 to 1; transform \(log(x+1)\); discretize (0 or 1)
pz<- as.data.frame(lapply(ppmi, scale))
str(pz)
## 'data.frame': 661 obs. of 70 variables:
## $ L_insular_cortex_ComputeArea : num 1.011 0.479 1.485 0.863 1.361 ...
## $ L_insular_cortex_Volume : num 0.909 0.69 1.792 0.99 1.647 ...
## $ R_insular_cortex_ComputeArea : num 1.187 0.753 1.152 0.997 0.852 ...
## $ R_insular_cortex_Volume : num 1.087 0.876 1.429 1.002 1.011 ...
## $ L_cingulate_gyrus_ComputeArea : num 1.052 0.124 1.274 0.76 0.897 ...
## $ L_cingulate_gyrus_Volume : num 1.0249 0.0789 1.336 0.7026 0.8483 ...
## $ R_cingulate_gyrus_ComputeArea : num 1.225 0.148 0.782 0.698 1.028 ...
## $ R_cingulate_gyrus_Volume : num 1.2914 0.0593 0.6571 0.7919 1.1138 ...
## $ L_caudate_ComputeArea : num 0.138 0.813 1.19 1.368 0.777 ...
## $ L_caudate_Volume : num -0.00625 0.76218 1.05293 1.33969 0.72885 ...
## $ R_caudate_ComputeArea : num 1.109 0.579 0.908 1.035 0.99 ...
## $ R_caudate_Volume : num 1.279 0.686 1.007 1.001 1.441 ...
## $ L_putamen_ComputeArea : num 0.444 1.019 1.501 0.493 0.911 ...
## $ L_putamen_Volume : num 0.00839 1.0961 1.42569 0.46577 0.89416 ...
## $ R_putamen_ComputeArea : num 0.895 0.301 0.175 0.566 0.151 ...
## $ R_putamen_Volume : num 0.6982 0.1661 0.03 0.4833 -0.0729 ...
## $ L_hippocampus_ComputeArea : num 0.975 0.478 0.788 0.524 1.201 ...
## $ L_hippocampus_Volume : num 1.182 0.52 0.997 0.508 1.408 ...
## $ R_hippocampus_ComputeArea : num 0.272 0.709 0.81 0.637 1.061 ...
## $ R_hippocampus_Volume : num 0.232 0.748 1.061 0.666 1.262 ...
## $ cerebellum_ComputeArea : num 0.94792 0.13047 -0.39763 0.00682 0.1683 ...
## $ cerebellum_Volume : num 1.1129 0.3752 -0.1577 0.0258 0.3651 ...
## $ L_fusiform_gyrus_ComputeArea : num 0.863 0.417 0.323 0.509 1.145 ...
## $ L_fusiform_gyrus_Volume : num 1.295 0.522 0.24 0.791 1.697 ...
## $ R_fusiform_gyrus_ComputeArea : num 0.592 0.198 0.909 0.567 1.821 ...
## $ R_fusiform_gyrus_Volume : num 1.091 0.269 1.025 1.074 1.855 ...
## $ R_fusiform_gyrus_ShapeIndex : num 1.067 0.163 0.8 0.704 1.983 ...
## $ R_fusiform_gyrus_Curvedness : num -0.2308 -0.0584 -0.2055 -0.1638 -0.2491 ...
## $ Sex : num -0.72 1.39 1.39 -0.72 1.39 ...
## $ Weight : num -0.4758 -0.6906 -0.0103 -0.0342 -0.7801 ...
## $ RG_ranked : num 0.689 0.689 0.689 -1.629 0.689 ...
## $ Age : num 0.391 0.636 -0.453 -0.183 -0.37 ...
## $ chr12_rs34637584_GT : num -0.0956 -0.0956 -0.0956 -0.0956 -0.0956 ...
## $ chr17_rs11868035_GT : num 0.6 0.6 0.6 0.6 -0.891 ...
## $ chr17_rs11012_GT : num 1.285 -0.645 1.285 1.285 1.285 ...
## $ chr17_rs393152_GT : num 1.02 -0.71 1.02 1.02 1.02 ...
## $ chr17_rs12185268_GT : num 1.109 -0.696 1.109 1.109 1.109 ...
## $ chr17_rs199533_GT : num -0.692 -0.692 1.159 1.159 1.159 ...
## $ UPDRS_Part_I_Summary_Score_Baseline : num -0.7349 1.2895 -0.0601 -0.7349 -0.0601 ...
## $ UPDRS_Part_I_Summary_Score_Month_03 : num -0.916 0.364 -0.276 0.205 0.364 ...
## $ UPDRS_Part_I_Summary_Score_Month_06 : num -0.893 2.006 -0.893 -0.165 -0.893 ...
## $ UPDRS_Part_I_Summary_Score_Month_09 : num -0.3003 -0.3003 -0.8627 0.0177 -0.3003 ...
## $ UPDRS_Part_I_Summary_Score_Month_12 : num 1.406 0.884 -0.684 -0.684 0.361 ...
## $ UPDRS_Part_I_Summary_Score_Month_18 : num -0.285 1.322 -0.4155 -0.0942 0.9666 ...
## $ UPDRS_Part_I_Summary_Score_Month_24 : num -0.6736 2.9003 -0.6736 -0.2268 0.0633 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline : num -0.563 2.33 0.327 -1.009 -0.118 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 : num -0.951 0.836 -0.281 -0.387 0.836 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 : num -0.7457 1.4302 -0.7457 -0.0253 0.8713 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 : num -0.98 1.952 0.148 0.281 0.148 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 : num -0.476 1.728 -0.109 -1.027 1.361 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 : num -0.673 1.741 0.38 -0.534 1.808 ...
## $ UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 : num -0.676 1.281 0.14 -1.002 0.796 ...
## $ UPDRS_Part_III_Summary_Score_Baseline : num -0.3403 0.0849 1.1054 -1.1908 0.5101 ...
## $ UPDRS_Part_III_Summary_Score_Month_03 : num -0.5079 -0.0487 1.6729 0.5886 0.8695 ...
## $ UPDRS_Part_III_Summary_Score_Month_06 : num 0.03 0.983 1.442 0.195 0.837 ...
## $ UPDRS_Part_III_Summary_Score_Month_09 : num -0.1536 -0.0647 1.091 -0.1388 1.0021 ...
## $ UPDRS_Part_III_Summary_Score_Month_12 : num 0.181 0.706 1.982 -1.095 1.156 ...
## $ UPDRS_Part_III_Summary_Score_Month_18 : num 0.476 -0.16 3.061 0.305 2.772 ...
## $ UPDRS_Part_III_Summary_Score_Month_24 : num 1.314 0.171 1.583 -0.837 1.286 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline : num -0.0346 2.0763 0.4931 -0.0346 -1.6178 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 : num 0.137 1.579 0.403 0.171 -1.722 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 : num -0.8471 1.9939 -0.0723 -0.0723 -0.0723 ...
## $ X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 : num 0.0485 1.0136 0.0485 0.7723 -0.2654 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline: num 0.515 0.515 -0.847 -0.166 -0.166 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06: num -0.735 1.6856 -0.735 -0.8503 -0.0122 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12: num -0.0584 0.6762 -0.793 -0.793 -0.0584 ...
## $ X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24: num -0.291 2.538 -0.998 0.417 -0.468 ...
## $ ctrl : num -0.579 -0.579 -0.579 1.726 -0.579 ...
## $ pd : num 0.723 0.723 0.723 -1.382 0.723 ...
## $ swedd : num -0.319 -0.319 -0.319 -0.319 -0.319 ...Partition data into training and testing sets:
use set.seed and random sample, train:test =
2:1
set.seed(1234)
sub<-sample(nrow(pz), floor(nrow(pz)*2/3))
pz_train<-pz[sub, ]
pz_test<-pz[-sub, ]
Y<-ifelse (pz$pd < 0.5, "No", "Yes")
pz_train_label<-Y[sub]
pz_test_label<-Y[-sub]
table(pz_train_label)
## pz_train_label
## No Yes
## 146 294Select the optimal k for each of the scaled data: Plot a error graph for \(k\), including three lines: training_error, cross-validation_error and testing_error, respectively
library(class)
library(ggplot2)
library(reshape2)
# define a function that generates CV folds
cv_partition <- function(y, num_folds = 10, seed = NULL) {
if(!is.null(seed)) {
set.seed(seed)
}
n <- length(y)
# split() divides the data into the folds defined by gl().
# gl() generates factors according to the pattern of their levels
folds <- split(sample(seq_len(n), n), gl(n = num_folds, k = 1, length = n))
folds <- lapply(folds, function(fold) {
list(
training = which(!seq_along(y) %in% fold),
test = fold
)
})
names(folds) <- paste0("Fold", names(folds))
return(folds)
}
# Generate 10-folds of the data
folds = cv_partition(pz_train_label, num_folds = 10)
train_cv_error = function(K) {
knn_model <- train(x=pz_train, y=pz_train_label , metric = "ROC", method = "knn", tuneLength = 20, trControl = knnControl)
summaryPredictions <- predict(knn_model, newdata = pz_train, type = "prob")
summaryPredictionsLabel <- ifelse (summaryPredictions$No == 1, "No", "Yes")
train_error = mean(summaryPredictionsLabel != pz_train_label)
#CV error
cverrbt = sapply(folds, function(fold) {
knn_model <- train(x=pz_train[fold$training,], y=pz_train_label[fold$training] , metric = "ROC", method = "knn", tuneLength = 20, trControl = knnControl)
summaryPredictions <- predict(knn_model, newdata = pz_train[fold$test,], type = "prob")
summaryPredictionsLabel <- ifelse (summaryPredictions$Yes == 1, "No", "Yes")
mean(summaryPredictionsLabel != pz_train_label[fold$test])
}
)
cv_error = mean(cverrbt)
#Test error
knn.test = knn(train = pz_train, test = pz_test, cl = pz_train_label, k = K)
test_error = mean(knn.test != pz_test_label)
return(c(train_error, cv_error, test_error))
}
k_err = sapply(1:30, function(k) train_cv_error(k))
df_errs = data.frame(t(k_err), 1:30)
colnames(df_errs) = c('Train', 'CV', 'Test', 'K')
dataL <- melt(df_errs, id="K")
library(plotly)
plot_ly(dataL, x = ~K, y = ~value, color = ~variable, type = "scatter", mode = "markers+lines") %>%
add_segments(x=25, xend=25, y=0.0, yend=0.3, type = "scatter", name="k=9",
line=list(color="darkgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=14, xend=14, y=0.0, yend=0.3, type = "scatter", name="k=14",
line=list(color="lightgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=18, xend=18, y=0.0, yend=0.3, type = "scatter", name="k=18",
line=list(color="gray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
layout(title='K-NN Training, CV, and Testing Error Rates against k',
legend=list(title=list(text='<b> Samples </b>')),
xaxis=list(title='Number of nearest neighbors (k)'), yaxis=list(title='Classification error'))
What is the impact of k?: Formulate a hypothesis
about the relation between \(k\) and
the error rates. You can try to use knn.tunning to verify
the results (Hint: select the same folds, all you may obtain a result
slightly different)
knntuning = tune.knn(x= pz_train, y = as.factor(pz_train_label), k = 1:50)
summary(knntuning) # k=1 is not applicable
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: 10-fold cross validation
##
## - best parameters:
## k
## 1
##
## - best performance: 0.01818182
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.01818182 0.03353931
## 2 2 0.02045455 0.02501148
## 3 3 0.02272727 0.02834589
## 4 4 0.02272727 0.02395665
## 5 5 0.02045455 0.02260066
## 6 6 0.02272727 0.02395665
## 7 7 0.02272727 0.02395665
## 8 8 0.02500000 0.02260066
## 9 9 0.02727273 0.02347263
## 10 10 0.02272727 0.02395665
## 11 11 0.02954545 0.02844694
## 12 12 0.02954545 0.02635231
## 13 13 0.03409091 0.02884763
## 14 14 0.03636364 0.02874798
## 15 15 0.04090909 0.03353931
## 16 16 0.04545455 0.03553345
## 17 17 0.04772727 0.03625299
## 18 18 0.04318182 0.03293495
## 19 19 0.04318182 0.03293495
## 20 20 0.04090909 0.02992184
## 21 21 0.04318182 0.03114364
## 22 22 0.04318182 0.03114364
## 23 23 0.04545455 0.03387982
## 24 24 0.04772727 0.03625299
## 25 25 0.04545455 0.03711348
## 26 26 0.04545455 0.04149413
## 27 27 0.04545455 0.03711348
## 28 28 0.04772727 0.03780295
## 29 29 0.04545455 0.03711348
## 30 30 0.05000000 0.03680290
## 31 31 0.04772727 0.03929183
## 32 32 0.05000000 0.03979977
## 33 33 0.04772727 0.03929183
## 34 34 0.04545455 0.03711348
## 35 35 0.04772727 0.03929183
## 36 36 0.05227273 0.03396441
## 37 37 0.05227273 0.04015866
## 38 38 0.05000000 0.03833064
## 39 39 0.05227273 0.03719072
## 40 40 0.05227273 0.03719072
## 41 41 0.05227273 0.03719072
## 42 42 0.05227273 0.04423879
## 43 43 0.05454545 0.04037246
## 44 44 0.05227273 0.03870315
## 45 45 0.05227273 0.03870315
## 46 46 0.05909091 0.04037246
## 47 47 0.05454545 0.03892495
## 48 48 0.05909091 0.04037246
## 49 49 0.05681818 0.03899860
## 50 50 0.05454545 0.04037246
knn_model <- train(x=pz_train, y=pz_train_label , metric = "ROC", method = "knn", tuneLength = 20, trControl = knnControl)
print(knn_model) # k = 15
## k-Nearest Neighbors
##
## 440 samples
## 70 predictor
## 2 classes: 'No', 'Yes'
##
## No pre-processing
## Resampling: Cross-Validated (10 fold)
## Summary of sample sizes: 396, 395, 396, 397, 397, 395, ...
## Resampling results across tuning parameters:
##
## k ROC Sens Spec
## 5 0.9914598 0.9380952 1.0000000
## 7 0.9908484 0.9180952 0.9966667
## 9 0.9933558 0.9109524 1.0000000
## 11 0.9929436 0.9038095 1.0000000
## 13 0.9945670 0.8833333 1.0000000
## 15 0.9961981 0.8695238 1.0000000
## 17 0.9948372 0.8552381 1.0000000
## 19 0.9945725 0.8623810 1.0000000
## 21 0.9933068 0.8685714 1.0000000
## 23 0.9918153 0.8619048 1.0000000
## 25 0.9912652 0.8619048 1.0000000
## 27 0.9916691 0.8480952 1.0000000
## 29 0.9905230 0.8480952 1.0000000
## 31 0.9889283 0.8480952 1.0000000
## 33 0.9886946 0.8480952 1.0000000
## 35 0.9897616 0.8547619 1.0000000
## 37 0.9889989 0.8480952 1.0000000
## 39 0.9874628 0.8409524 1.0000000
## 41 0.9856959 0.8409524 1.0000000
## 43 0.9859587 0.8409524 1.0000000
##
## ROC was used to select the optimal model using the largest value.
## The final value used for the model was k = 15.Interpret the results: Hint: Considering the number of dimension of the data, how many points are necessary to obtain the same density result for 100 dimensional space compared to a 1 dimensional space?
pz_test_pred11 <- knn(train=pz_train, test=pz_test, cl=pz_train_label, prob=T, k=15)
pz_test_predBin11 <- ifelse(attributes(pz_test_pred11)$prob == 1, "No", "Yes")
CT <- CrossTable(x=pz_test_label, y=pz_test_predBin11, prop.chisq = F)
##
##
## Cell Contents
## |-------------------------|
## | N |
## | N / Row Total |
## | N / Col Total |
## | N / Table Total |
## |-------------------------|
##
##
## Total Observations in Table: 221
##
##
## | pz_test_predBin11
## pz_test_label | No | Yes | Row Total |
## --------------|-----------|-----------|-----------|
## No | 39 | 42 | 81 |
## | 0.481 | 0.519 | 0.367 |
## | 0.275 | 0.532 | |
## | 0.176 | 0.190 | |
## --------------|-----------|-----------|-----------|
## Yes | 103 | 37 | 140 |
## | 0.736 | 0.264 | 0.633 |
## | 0.725 | 0.468 | |
## | 0.466 | 0.167 | |
## --------------|-----------|-----------|-----------|
## Column Total | 142 | 79 | 221 |
## | 0.643 | 0.357 | |
## --------------|-----------|-----------|-----------|
##
##
print(paste0("Prediction accuracy of model 'pz_test_pred' (k=15) is ", (CT1$prop.tbl[1,1]+CT1$prop.tbl[2,2]) ))
## [1] "Prediction accuracy of model 'pz_test_pred' (k=15) is 0.434782608695652"
mod15_TN <- CT$prop.row[1, 1]
mod15_FP <- CT$prop.row[1, 2]
mod15_FN <- CT$prop.row[2, 1]
mod15_TP <- CT$prop.row[2, 2]
mod15_sensi <- mod15_TN/(mod15_TN+mod15_FP)
mod15_speci <- mod15_TP/(mod15_TP+mod15_FN)
print(paste0("kNN model k=15 Sensitivity=", mod15_sensi))
## [1] "kNN model k=15 Sensitivity=0.481481481481481"
print(paste0("kNN model k-15 Specificity=", mod15_speci))
## [1] "kNN model k-15 Specificity=0.264285714285714"
library(mclust)
## Warning: package 'mclust' was built under R version 4.2.3
## Package 'mclust' version 6.0.0
## Type 'citation("mclust")' for citing this R package in publications.
gmm_clust <- Mclust(pz)
summary(gmm_clust, parameters = TRUE)
## ----------------------------------------------------
## Gaussian finite mixture model fitted by EM algorithm
## ----------------------------------------------------
##
## Mclust XXX (ellipsoidal multivariate normal) model with 1 component:
##
## log-likelihood n df BIC ICL
## 14006.87 661 2555 11422.2 11422.2
##
## Clustering table:
## 1
## 661
##
## Mixing probabilities:
## 1
## 1
##
## Means:
## [,1]
## L_insular_cortex_ComputeArea 2.927346e-18
## L_insular_cortex_Volume 1.935301e-17
## R_insular_cortex_ComputeArea 6.722053e-17
## R_insular_cortex_Volume -1.153591e-16
## L_cingulate_gyrus_ComputeArea -2.125036e-17
## L_cingulate_gyrus_Volume 6.353425e-17
## R_cingulate_gyrus_ComputeArea 2.988061e-16
## R_cingulate_gyrus_Volume 1.951564e-17
## L_caudate_ComputeArea 2.515349e-17
## L_caudate_Volume -1.561251e-17
## R_caudate_ComputeArea -9.822872e-17
## R_caudate_Volume -6.700369e-17
## L_putamen_ComputeArea 1.803028e-16
## L_putamen_Volume -2.602085e-18
## R_putamen_ComputeArea -5.117434e-17
## R_putamen_Volume -2.064321e-16
## L_hippocampus_ComputeArea -4.336809e-17
## L_hippocampus_Volume 7.329207e-17
## R_hippocampus_ComputeArea 1.218643e-16
## R_hippocampus_Volume -6.071532e-18
## cerebellum_ComputeArea 4.127558e-16
## cerebellum_Volume 7.589415e-18
## L_fusiform_gyrus_ComputeArea 9.638557e-17
## L_fusiform_gyrus_Volume 1.012645e-16
## R_fusiform_gyrus_ComputeArea 3.035766e-18
## R_fusiform_gyrus_Volume -1.778092e-17
## R_fusiform_gyrus_ShapeIndex -7.732530e-16
## R_fusiform_gyrus_Curvedness -3.835365e-18
## Sex -8.673617e-17
## Weight 4.435742e-16
## RG_ranked -6.895526e-17
## Age 6.895526e-17
## chr12_rs34637584_GT -1.365553e-16
## chr17_rs11868035_GT -1.305379e-16
## chr17_rs11012_GT 5.644357e-16
## chr17_rs393152_GT 8.673617e-17
## chr17_rs12185268_GT -2.146720e-16
## chr17_rs199533_GT 3.816392e-17
## UPDRS_Part_I_Summary_Score_Baseline 9.450177e-17
## UPDRS_Part_I_Summary_Score_Month_03 8.673617e-19
## UPDRS_Part_I_Summary_Score_Month_06 5.789640e-17
## UPDRS_Part_I_Summary_Score_Month_09 1.355253e-17
## UPDRS_Part_I_Summary_Score_Month_12 -1.242767e-16
## UPDRS_Part_I_Summary_Score_Month_18 -9.194034e-17
## UPDRS_Part_I_Summary_Score_Month_24 1.864828e-17
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline -5.421011e-18
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 2.623769e-17
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -1.084202e-19
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -4.813858e-17
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 2.099015e-16
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -5.312591e-17
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -1.057097e-17
## UPDRS_Part_III_Summary_Score_Baseline -2.151057e-16
## UPDRS_Part_III_Summary_Score_Month_03 -2.129373e-16
## UPDRS_Part_III_Summary_Score_Month_06 2.190088e-17
## UPDRS_Part_III_Summary_Score_Month_09 -3.642919e-17
## UPDRS_Part_III_Summary_Score_Month_12 9.367507e-17
## UPDRS_Part_III_Summary_Score_Month_18 -1.328148e-16
## UPDRS_Part_III_Summary_Score_Month_24 -3.014082e-17
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -7.979728e-17
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 2.428613e-17
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 3.469447e-17
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 1.231654e-16
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 8.831911e-16
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 3.404395e-17
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 2.130186e-16
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -1.144917e-16
## ctrl -3.551846e-16
## pd 2.428613e-17
## swedd 1.093635e-15
##
## Variances:
## [,,1]
## L_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.998487141
## L_insular_cortex_Volume 0.985417609
## R_insular_cortex_ComputeArea 0.932853455
## R_insular_cortex_Volume 0.920925698
## L_cingulate_gyrus_ComputeArea 0.905246541
## L_cingulate_gyrus_Volume 0.893662690
## R_cingulate_gyrus_ComputeArea 0.877357965
## R_cingulate_gyrus_Volume 0.866816992
## L_caudate_ComputeArea 0.778998817
## L_caudate_Volume 0.734550083
## R_caudate_ComputeArea 0.871349351
## R_caudate_Volume 0.845314594
## L_putamen_ComputeArea 0.805305689
## L_putamen_Volume 0.797139538
## R_putamen_ComputeArea 0.861717828
## R_putamen_Volume 0.864351779
## L_hippocampus_ComputeArea 0.858451786
## L_hippocampus_Volume 0.866763777
## R_hippocampus_ComputeArea 0.796504324
## R_hippocampus_Volume 0.809571058
## cerebellum_ComputeArea 0.082968835
## cerebellum_Volume 0.253718714
## L_fusiform_gyrus_ComputeArea 0.255742782
## L_fusiform_gyrus_Volume 0.552187653
## R_fusiform_gyrus_ComputeArea 0.323295781
## R_fusiform_gyrus_Volume 0.520010259
## R_fusiform_gyrus_ShapeIndex 0.137684464
## R_fusiform_gyrus_Curvedness -0.094616638
## Sex -0.006203877
## Weight -0.049917375
## RG_ranked 0.092257806
## Age -0.160255977
## chr12_rs34637584_GT 0.023098896
## chr17_rs11868035_GT 0.031755583
## chr17_rs11012_GT 0.020187711
## chr17_rs393152_GT 0.044828373
## chr17_rs12185268_GT 0.041831028
## chr17_rs199533_GT 0.023673839
## UPDRS_Part_I_Summary_Score_Baseline -0.009374415
## UPDRS_Part_I_Summary_Score_Month_03 -0.012453230
## UPDRS_Part_I_Summary_Score_Month_06 -0.079167932
## UPDRS_Part_I_Summary_Score_Month_09 -0.054935336
## UPDRS_Part_I_Summary_Score_Month_12 -0.059589111
## UPDRS_Part_I_Summary_Score_Month_18 -0.048619887
## UPDRS_Part_I_Summary_Score_Month_24 -0.051307730
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.053138531
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.027975538
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.008323274
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.015861794
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.012503536
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.026247398
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.022763949
## UPDRS_Part_III_Summary_Score_Baseline 0.040491022
## UPDRS_Part_III_Summary_Score_Month_03 0.010966504
## UPDRS_Part_III_Summary_Score_Month_06 0.019709904
## UPDRS_Part_III_Summary_Score_Month_09 0.021356760
## UPDRS_Part_III_Summary_Score_Month_12 0.071378789
## UPDRS_Part_III_Summary_Score_Month_18 0.053281049
## UPDRS_Part_III_Summary_Score_Month_24 0.060024741
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.054390879
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.057004372
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.082590149
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.021140102
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.042011240
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.011926534
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.016987497
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.025669975
## ctrl -0.058317848
## pd 0.114248772
## swedd -0.100061696
## L_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.985417609
## L_insular_cortex_Volume 0.998487141
## R_insular_cortex_ComputeArea 0.929814332
## R_insular_cortex_Volume 0.932662581
## L_cingulate_gyrus_ComputeArea 0.905071319
## L_cingulate_gyrus_Volume 0.904799670
## R_cingulate_gyrus_ComputeArea 0.871369872
## R_cingulate_gyrus_Volume 0.868965824
## L_caudate_ComputeArea 0.801542231
## L_caudate_Volume 0.767242490
## R_caudate_ComputeArea 0.875057343
## R_caudate_Volume 0.859799690
## L_putamen_ComputeArea 0.814656792
## L_putamen_Volume 0.820014318
## R_putamen_ComputeArea 0.853732787
## R_putamen_Volume 0.866698797
## L_hippocampus_ComputeArea 0.842764032
## L_hippocampus_Volume 0.862093394
## R_hippocampus_ComputeArea 0.773481420
## R_hippocampus_Volume 0.791591705
## cerebellum_ComputeArea 0.045591229
## cerebellum_Volume 0.221825830
## L_fusiform_gyrus_ComputeArea 0.216267645
## L_fusiform_gyrus_Volume 0.522926348
## R_fusiform_gyrus_ComputeArea 0.299986799
## R_fusiform_gyrus_Volume 0.507556381
## R_fusiform_gyrus_ShapeIndex 0.121778159
## R_fusiform_gyrus_Curvedness -0.088703298
## Sex -0.005354519
## Weight -0.045290184
## RG_ranked 0.094892253
## Age -0.165551377
## chr12_rs34637584_GT 0.027830890
## chr17_rs11868035_GT 0.043814343
## chr17_rs11012_GT 0.019220652
## chr17_rs393152_GT 0.041678702
## chr17_rs12185268_GT 0.044211374
## chr17_rs199533_GT 0.020008811
## UPDRS_Part_I_Summary_Score_Baseline -0.015684937
## UPDRS_Part_I_Summary_Score_Month_03 -0.010321811
## UPDRS_Part_I_Summary_Score_Month_06 -0.076403986
## UPDRS_Part_I_Summary_Score_Month_09 -0.055750417
## UPDRS_Part_I_Summary_Score_Month_12 -0.056604522
## UPDRS_Part_I_Summary_Score_Month_18 -0.045266568
## UPDRS_Part_I_Summary_Score_Month_24 -0.052011221
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.057532060
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.033028559
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.011026557
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.011633409
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.018307742
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.030569468
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.025436994
## UPDRS_Part_III_Summary_Score_Baseline 0.038286628
## UPDRS_Part_III_Summary_Score_Month_03 0.005247408
## UPDRS_Part_III_Summary_Score_Month_06 0.012052739
## UPDRS_Part_III_Summary_Score_Month_09 0.021692917
## UPDRS_Part_III_Summary_Score_Month_12 0.077022464
## UPDRS_Part_III_Summary_Score_Month_18 0.060650349
## UPDRS_Part_III_Summary_Score_Month_24 0.061617864
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.059591902
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.068583280
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.083690078
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.027240511
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.038950951
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.010744994
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.013409962
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.033277109
## ctrl -0.060824309
## pd 0.116742955
## swedd -0.100398209
## R_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.932853455
## L_insular_cortex_Volume 0.929814332
## R_insular_cortex_ComputeArea 0.998487141
## R_insular_cortex_Volume 0.984993003
## L_cingulate_gyrus_ComputeArea 0.918439841
## L_cingulate_gyrus_Volume 0.909879025
## R_cingulate_gyrus_ComputeArea 0.898751702
## R_cingulate_gyrus_Volume 0.886455799
## L_caudate_ComputeArea 0.808394446
## L_caudate_Volume 0.766136382
## R_caudate_ComputeArea 0.898624279
## R_caudate_Volume 0.873055625
## L_putamen_ComputeArea 0.809258225
## L_putamen_Volume 0.811040899
## R_putamen_ComputeArea 0.876832464
## R_putamen_Volume 0.887203280
## L_hippocampus_ComputeArea 0.863572136
## L_hippocampus_Volume 0.873728530
## R_hippocampus_ComputeArea 0.829444139
## R_hippocampus_Volume 0.832730675
## cerebellum_ComputeArea 0.025987705
## cerebellum_Volume 0.216763973
## L_fusiform_gyrus_ComputeArea 0.246130432
## L_fusiform_gyrus_Volume 0.548089926
## R_fusiform_gyrus_ComputeArea 0.349669467
## R_fusiform_gyrus_Volume 0.548354536
## R_fusiform_gyrus_ShapeIndex 0.167581672
## R_fusiform_gyrus_Curvedness -0.091136404
## Sex 0.010032526
## Weight -0.050521141
## RG_ranked 0.123299569
## Age -0.172016625
## chr12_rs34637584_GT 0.051633090
## chr17_rs11868035_GT 0.038926949
## chr17_rs11012_GT 0.023598667
## chr17_rs393152_GT 0.043267816
## chr17_rs12185268_GT 0.038720909
## chr17_rs199533_GT 0.034215507
## UPDRS_Part_I_Summary_Score_Baseline 0.002133536
## UPDRS_Part_I_Summary_Score_Month_03 0.009991644
## UPDRS_Part_I_Summary_Score_Month_06 -0.062858873
## UPDRS_Part_I_Summary_Score_Month_09 -0.053175869
## UPDRS_Part_I_Summary_Score_Month_12 -0.054400831
## UPDRS_Part_I_Summary_Score_Month_18 -0.046581375
## UPDRS_Part_I_Summary_Score_Month_24 -0.042677210
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.071720219
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.033340029
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.012221997
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.008228332
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.025034433
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.017606869
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.034586615
## UPDRS_Part_III_Summary_Score_Baseline 0.064828604
## UPDRS_Part_III_Summary_Score_Month_03 0.015008696
## UPDRS_Part_III_Summary_Score_Month_06 0.038734439
## UPDRS_Part_III_Summary_Score_Month_09 0.033563671
## UPDRS_Part_III_Summary_Score_Month_12 0.094168607
## UPDRS_Part_III_Summary_Score_Month_18 0.055352633
## UPDRS_Part_III_Summary_Score_Month_24 0.078560086
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.056853131
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.075511317
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.083411334
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.026632249
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.026027848
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.021764080
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.022099506
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.011428406
## ctrl -0.087696331
## pd 0.143779547
## swedd -0.104491970
## R_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.9209256980
## L_insular_cortex_Volume 0.9326625809
## R_insular_cortex_ComputeArea 0.9849930026
## R_insular_cortex_Volume 0.9984871407
## L_cingulate_gyrus_ComputeArea 0.9114751990
## L_cingulate_gyrus_Volume 0.9159251230
## R_cingulate_gyrus_ComputeArea 0.8787185273
## R_cingulate_gyrus_Volume 0.8739271345
## L_caudate_ComputeArea 0.8369929928
## L_caudate_Volume 0.8070001923
## R_caudate_ComputeArea 0.8884633015
## R_caudate_Volume 0.8741898668
## L_putamen_ComputeArea 0.8191693561
## L_putamen_Volume 0.8360185629
## R_putamen_ComputeArea 0.8612340005
## R_putamen_Volume 0.8809664040
## L_hippocampus_ComputeArea 0.8440627707
## L_hippocampus_Volume 0.8635414997
## R_hippocampus_ComputeArea 0.7972590900
## R_hippocampus_Volume 0.8060367138
## cerebellum_ComputeArea -0.0011595548
## cerebellum_Volume 0.1943536235
## L_fusiform_gyrus_ComputeArea 0.2067216352
## L_fusiform_gyrus_Volume 0.5129586011
## R_fusiform_gyrus_ComputeArea 0.3281260862
## R_fusiform_gyrus_Volume 0.5333147770
## R_fusiform_gyrus_ShapeIndex 0.1530356763
## R_fusiform_gyrus_Curvedness -0.0949546605
## Sex 0.0002925381
## Weight -0.0422373226
## RG_ranked 0.1265700346
## Age -0.1897453455
## chr12_rs34637584_GT 0.0453035050
## chr17_rs11868035_GT 0.0490981241
## chr17_rs11012_GT 0.0260027323
## chr17_rs393152_GT 0.0444662949
## chr17_rs12185268_GT 0.0428400578
## chr17_rs199533_GT 0.0346255584
## UPDRS_Part_I_Summary_Score_Baseline -0.0181953313
## UPDRS_Part_I_Summary_Score_Month_03 0.0059169592
## UPDRS_Part_I_Summary_Score_Month_06 -0.0675982721
## UPDRS_Part_I_Summary_Score_Month_09 -0.0631636553
## UPDRS_Part_I_Summary_Score_Month_12 -0.0623396136
## UPDRS_Part_I_Summary_Score_Month_18 -0.0570836758
## UPDRS_Part_I_Summary_Score_Month_24 -0.0563035084
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0688973649
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0367188713
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0097393578
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0086714474
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0262549641
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0143737007
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0306823402
## UPDRS_Part_III_Summary_Score_Baseline 0.0550956096
## UPDRS_Part_III_Summary_Score_Month_03 0.0107473530
## UPDRS_Part_III_Summary_Score_Month_06 0.0304092617
## UPDRS_Part_III_Summary_Score_Month_09 0.0292713193
## UPDRS_Part_III_Summary_Score_Month_12 0.0950518679
## UPDRS_Part_III_Summary_Score_Month_18 0.0595259612
## UPDRS_Part_III_Summary_Score_Month_24 0.0773459952
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0708987221
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0882969653
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0915143692
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0390718417
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0358821661
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0122133727
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0124544519
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0009180699
## ctrl -0.0889248249
## pd 0.1485956501
## swedd -0.1105528083
## L_cingulate_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.905246541
## L_insular_cortex_Volume 0.905071319
## R_insular_cortex_ComputeArea 0.918439841
## R_insular_cortex_Volume 0.911475199
## L_cingulate_gyrus_ComputeArea 0.998487141
## L_cingulate_gyrus_Volume 0.987530580
## R_cingulate_gyrus_ComputeArea 0.953882491
## R_cingulate_gyrus_Volume 0.944572448
## L_caudate_ComputeArea 0.783873578
## L_caudate_Volume 0.746291211
## R_caudate_ComputeArea 0.879018158
## R_caudate_Volume 0.870591970
## L_putamen_ComputeArea 0.823945008
## L_putamen_Volume 0.829323702
## R_putamen_ComputeArea 0.863380763
## R_putamen_Volume 0.880255152
## L_hippocampus_ComputeArea 0.815712913
## L_hippocampus_Volume 0.832011305
## R_hippocampus_ComputeArea 0.742197042
## R_hippocampus_Volume 0.756314002
## cerebellum_ComputeArea 0.029948161
## cerebellum_Volume 0.190096573
## L_fusiform_gyrus_ComputeArea 0.272012045
## L_fusiform_gyrus_Volume 0.546682712
## R_fusiform_gyrus_ComputeArea 0.333909894
## R_fusiform_gyrus_Volume 0.521342525
## R_fusiform_gyrus_ShapeIndex 0.156718909
## R_fusiform_gyrus_Curvedness -0.098932610
## Sex 0.012974113
## Weight -0.030572296
## RG_ranked 0.103175533
## Age -0.134615200
## chr12_rs34637584_GT 0.020305771
## chr17_rs11868035_GT 0.051545416
## chr17_rs11012_GT 0.020752181
## chr17_rs393152_GT 0.038983699
## chr17_rs12185268_GT 0.038920271
## chr17_rs199533_GT 0.026237731
## UPDRS_Part_I_Summary_Score_Baseline 0.018193349
## UPDRS_Part_I_Summary_Score_Month_03 0.015853060
## UPDRS_Part_I_Summary_Score_Month_06 -0.042073149
## UPDRS_Part_I_Summary_Score_Month_09 -0.036207694
## UPDRS_Part_I_Summary_Score_Month_12 -0.034674791
## UPDRS_Part_I_Summary_Score_Month_18 -0.023394696
## UPDRS_Part_I_Summary_Score_Month_24 -0.018508038
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.063145967
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.037076483
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.008097614
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.004334631
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.027700072
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.027485946
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.052475930
## UPDRS_Part_III_Summary_Score_Baseline 0.076262543
## UPDRS_Part_III_Summary_Score_Month_03 0.046495493
## UPDRS_Part_III_Summary_Score_Month_06 0.060548055
## UPDRS_Part_III_Summary_Score_Month_09 0.076180474
## UPDRS_Part_III_Summary_Score_Month_12 0.116407462
## UPDRS_Part_III_Summary_Score_Month_18 0.118392725
## UPDRS_Part_III_Summary_Score_Month_24 0.102872197
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.053751417
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.056734496
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.065593500
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.015904575
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.023092986
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.030477534
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.041497070
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.004235000
## ctrl -0.072406619
## pd 0.121204794
## swedd -0.090364080
## L_cingulate_gyrus_Volume
## L_insular_cortex_ComputeArea 0.8936626901
## L_insular_cortex_Volume 0.9047996696
## R_insular_cortex_ComputeArea 0.9098790250
## R_insular_cortex_Volume 0.9159251230
## L_cingulate_gyrus_ComputeArea 0.9875305799
## L_cingulate_gyrus_Volume 0.9984871407
## R_cingulate_gyrus_ComputeArea 0.9411002485
## R_cingulate_gyrus_Volume 0.9469974322
## L_caudate_ComputeArea 0.7890465612
## L_caudate_Volume 0.7589047094
## R_caudate_ComputeArea 0.8791424432
## R_caudate_Volume 0.8785380729
## L_putamen_ComputeArea 0.8197356795
## L_putamen_Volume 0.8369248951
## R_putamen_ComputeArea 0.8563864457
## R_putamen_Volume 0.8841173515
## L_hippocampus_ComputeArea 0.8114800467
## L_hippocampus_Volume 0.8347839135
## R_hippocampus_ComputeArea 0.7352330603
## R_hippocampus_Volume 0.7531901447
## cerebellum_ComputeArea -0.0018278100
## cerebellum_Volume 0.1685617145
## L_fusiform_gyrus_ComputeArea 0.2342750858
## L_fusiform_gyrus_Volume 0.5226112717
## R_fusiform_gyrus_ComputeArea 0.3132763715
## R_fusiform_gyrus_Volume 0.5144362408
## R_fusiform_gyrus_ShapeIndex 0.1483761173
## R_fusiform_gyrus_Curvedness -0.0962055605
## Sex -0.0090851439
## Weight -0.0160890760
## RG_ranked 0.1030768579
## Age -0.1274193204
## chr12_rs34637584_GT 0.0173659877
## chr17_rs11868035_GT 0.0559811182
## chr17_rs11012_GT 0.0271710397
## chr17_rs393152_GT 0.0391457883
## chr17_rs12185268_GT 0.0405439434
## chr17_rs199533_GT 0.0242222818
## UPDRS_Part_I_Summary_Score_Baseline -0.0002514912
## UPDRS_Part_I_Summary_Score_Month_03 0.0114968046
## UPDRS_Part_I_Summary_Score_Month_06 -0.0576844842
## UPDRS_Part_I_Summary_Score_Month_09 -0.0485212393
## UPDRS_Part_I_Summary_Score_Month_12 -0.0483199327
## UPDRS_Part_I_Summary_Score_Month_18 -0.0379571189
## UPDRS_Part_I_Summary_Score_Month_24 -0.0373041389
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0563031963
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0347648845
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.0005222306
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0030319172
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0216521406
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0201337351
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0458320604
## UPDRS_Part_III_Summary_Score_Baseline 0.0731534346
## UPDRS_Part_III_Summary_Score_Month_03 0.0429726892
## UPDRS_Part_III_Summary_Score_Month_06 0.0530436462
## UPDRS_Part_III_Summary_Score_Month_09 0.0686900952
## UPDRS_Part_III_Summary_Score_Month_12 0.1108754816
## UPDRS_Part_III_Summary_Score_Month_18 0.1181135404
## UPDRS_Part_III_Summary_Score_Month_24 0.0981964276
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0675157873
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0764717009
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0767990452
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0242499506
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0331855770
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0166807000
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0289976964
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0104606281
## ctrl -0.0694836258
## pd 0.1236951139
## swedd -0.0988295309
## R_cingulate_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.877357965
## L_insular_cortex_Volume 0.871369872
## R_insular_cortex_ComputeArea 0.898751702
## R_insular_cortex_Volume 0.878718527
## L_cingulate_gyrus_ComputeArea 0.953882491
## L_cingulate_gyrus_Volume 0.941100248
## R_cingulate_gyrus_ComputeArea 0.998487141
## R_cingulate_gyrus_Volume 0.985612456
## L_caudate_ComputeArea 0.721269130
## L_caudate_Volume 0.680053587
## R_caudate_ComputeArea 0.865767334
## R_caudate_Volume 0.848648377
## L_putamen_ComputeArea 0.792352062
## L_putamen_Volume 0.792176926
## R_putamen_ComputeArea 0.847118415
## R_putamen_Volume 0.857464946
## L_hippocampus_ComputeArea 0.810807188
## L_hippocampus_Volume 0.824134693
## R_hippocampus_ComputeArea 0.755550718
## R_hippocampus_Volume 0.767561504
## cerebellum_ComputeArea 0.022031878
## cerebellum_Volume 0.182988391
## L_fusiform_gyrus_ComputeArea 0.285347819
## L_fusiform_gyrus_Volume 0.562174407
## R_fusiform_gyrus_ComputeArea 0.328129143
## R_fusiform_gyrus_Volume 0.512323607
## R_fusiform_gyrus_ShapeIndex 0.152634543
## R_fusiform_gyrus_Curvedness -0.097831221
## Sex 0.013988122
## Weight -0.061658989
## RG_ranked 0.093177371
## Age -0.093278363
## chr12_rs34637584_GT 0.035862611
## chr17_rs11868035_GT 0.059395164
## chr17_rs11012_GT 0.031682458
## chr17_rs393152_GT 0.049050470
## chr17_rs12185268_GT 0.049904553
## chr17_rs199533_GT 0.029250348
## UPDRS_Part_I_Summary_Score_Baseline 0.010212900
## UPDRS_Part_I_Summary_Score_Month_03 -0.001853545
## UPDRS_Part_I_Summary_Score_Month_06 -0.046074297
## UPDRS_Part_I_Summary_Score_Month_09 -0.046139491
## UPDRS_Part_I_Summary_Score_Month_12 -0.046291661
## UPDRS_Part_I_Summary_Score_Month_18 -0.043036780
## UPDRS_Part_I_Summary_Score_Month_24 -0.028309355
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.051110420
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.016901092
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.012392552
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.023770264
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.008722053
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.003388804
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.037454177
## UPDRS_Part_III_Summary_Score_Baseline 0.074402788
## UPDRS_Part_III_Summary_Score_Month_03 0.038763713
## UPDRS_Part_III_Summary_Score_Month_06 0.051764591
## UPDRS_Part_III_Summary_Score_Month_09 0.062158418
## UPDRS_Part_III_Summary_Score_Month_12 0.100535232
## UPDRS_Part_III_Summary_Score_Month_18 0.101911371
## UPDRS_Part_III_Summary_Score_Month_24 0.094117483
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.042752672
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.053780389
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.074670465
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.023694678
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.014664424
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.018478562
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.034777948
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.012612355
## ctrl -0.058689971
## pd 0.115578540
## swedd -0.101685812
## R_cingulate_gyrus_Volume
## L_insular_cortex_ComputeArea 0.866816992
## L_insular_cortex_Volume 0.868965824
## R_insular_cortex_ComputeArea 0.886455799
## R_insular_cortex_Volume 0.873927134
## L_cingulate_gyrus_ComputeArea 0.944572448
## L_cingulate_gyrus_Volume 0.946997432
## R_cingulate_gyrus_ComputeArea 0.985612456
## R_cingulate_gyrus_Volume 0.998487141
## L_caudate_ComputeArea 0.710407857
## L_caudate_Volume 0.673116745
## R_caudate_ComputeArea 0.863152907
## R_caudate_Volume 0.853143706
## L_putamen_ComputeArea 0.778627549
## L_putamen_Volume 0.788450579
## R_putamen_ComputeArea 0.837866652
## R_putamen_Volume 0.856889128
## L_hippocampus_ComputeArea 0.812009097
## L_hippocampus_Volume 0.832047972
## R_hippocampus_ComputeArea 0.755383440
## R_hippocampus_Volume 0.772535355
## cerebellum_ComputeArea -0.010182356
## cerebellum_Volume 0.163804663
## L_fusiform_gyrus_ComputeArea 0.255335615
## L_fusiform_gyrus_Volume 0.547327837
## R_fusiform_gyrus_ComputeArea 0.310690877
## R_fusiform_gyrus_Volume 0.509489690
## R_fusiform_gyrus_ShapeIndex 0.150342672
## R_fusiform_gyrus_Curvedness -0.094905773
## Sex -0.005881723
## Weight -0.048443353
## RG_ranked 0.096605772
## Age -0.075361953
## chr12_rs34637584_GT 0.027486408
## chr17_rs11868035_GT 0.062161342
## chr17_rs11012_GT 0.026589949
## chr17_rs393152_GT 0.042640213
## chr17_rs12185268_GT 0.043378945
## chr17_rs199533_GT 0.020758247
## UPDRS_Part_I_Summary_Score_Baseline -0.002138797
## UPDRS_Part_I_Summary_Score_Month_03 -0.007704410
## UPDRS_Part_I_Summary_Score_Month_06 -0.053542568
## UPDRS_Part_I_Summary_Score_Month_09 -0.050707536
## UPDRS_Part_I_Summary_Score_Month_12 -0.053594257
## UPDRS_Part_I_Summary_Score_Month_18 -0.050101163
## UPDRS_Part_I_Summary_Score_Month_24 -0.038202657
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.040754932
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.006328308
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.022923147
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.036482890
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.000311588
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.002979736
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.029507875
## UPDRS_Part_III_Summary_Score_Baseline 0.074223759
## UPDRS_Part_III_Summary_Score_Month_03 0.030950254
## UPDRS_Part_III_Summary_Score_Month_06 0.045213591
## UPDRS_Part_III_Summary_Score_Month_09 0.056344632
## UPDRS_Part_III_Summary_Score_Month_12 0.094805127
## UPDRS_Part_III_Summary_Score_Month_18 0.105766875
## UPDRS_Part_III_Summary_Score_Month_24 0.091290367
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.048105826
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.064362863
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.080159946
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.028430315
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.030629327
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.002264916
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.025008467
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.007579104
## ctrl -0.058740811
## pd 0.121756915
## swedd -0.111746216
## L_caudate_ComputeArea
## L_insular_cortex_ComputeArea 0.778998817
## L_insular_cortex_Volume 0.801542231
## R_insular_cortex_ComputeArea 0.808394446
## R_insular_cortex_Volume 0.836992993
## L_cingulate_gyrus_ComputeArea 0.783873578
## L_cingulate_gyrus_Volume 0.789046561
## R_cingulate_gyrus_ComputeArea 0.721269130
## R_cingulate_gyrus_Volume 0.710407857
## L_caudate_ComputeArea 0.998487141
## L_caudate_Volume 0.984408955
## R_caudate_ComputeArea 0.845776505
## R_caudate_Volume 0.857714949
## L_putamen_ComputeArea 0.756095890
## L_putamen_Volume 0.788759391
## R_putamen_ComputeArea 0.723370623
## R_putamen_Volume 0.749523164
## L_hippocampus_ComputeArea 0.681469515
## L_hippocampus_Volume 0.703078314
## R_hippocampus_ComputeArea 0.606960336
## R_hippocampus_Volume 0.619183087
## cerebellum_ComputeArea -0.058947535
## cerebellum_Volume 0.108058374
## L_fusiform_gyrus_ComputeArea 0.145845813
## L_fusiform_gyrus_Volume 0.394544674
## R_fusiform_gyrus_ComputeArea 0.221275147
## R_fusiform_gyrus_Volume 0.391473344
## R_fusiform_gyrus_ShapeIndex 0.120890290
## R_fusiform_gyrus_Curvedness -0.095337759
## Sex 0.110521356
## Weight -0.086025750
## RG_ranked 0.090598359
## Age -0.345837437
## chr12_rs34637584_GT 0.072170325
## chr17_rs11868035_GT 0.056558668
## chr17_rs11012_GT 0.001388321
## chr17_rs393152_GT 0.006199035
## chr17_rs12185268_GT 0.009381282
## chr17_rs199533_GT 0.008080777
## UPDRS_Part_I_Summary_Score_Baseline -0.008759147
## UPDRS_Part_I_Summary_Score_Month_03 0.019480243
## UPDRS_Part_I_Summary_Score_Month_06 -0.042463722
## UPDRS_Part_I_Summary_Score_Month_09 -0.091685851
## UPDRS_Part_I_Summary_Score_Month_12 -0.071505526
## UPDRS_Part_I_Summary_Score_Month_18 -0.051010557
## UPDRS_Part_I_Summary_Score_Month_24 -0.074295474
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.031578045
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.027637428
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.038874903
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.060611527
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.007038122
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.011267270
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -0.022524265
## UPDRS_Part_III_Summary_Score_Baseline -0.010219244
## UPDRS_Part_III_Summary_Score_Month_03 -0.047517989
## UPDRS_Part_III_Summary_Score_Month_06 -0.013143915
## UPDRS_Part_III_Summary_Score_Month_09 -0.010754002
## UPDRS_Part_III_Summary_Score_Month_12 0.055569564
## UPDRS_Part_III_Summary_Score_Month_18 0.025745734
## UPDRS_Part_III_Summary_Score_Month_24 0.003945830
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.040472774
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.086564572
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.079849343
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.046044622
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.033765430
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.067568341
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.009765524
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.014879565
## ctrl -0.068122496
## pd 0.102281499
## swedd -0.065736640
## L_caudate_Volume
## L_insular_cortex_ComputeArea 0.734550083
## L_insular_cortex_Volume 0.767242490
## R_insular_cortex_ComputeArea 0.766136382
## R_insular_cortex_Volume 0.807000192
## L_cingulate_gyrus_ComputeArea 0.746291211
## L_cingulate_gyrus_Volume 0.758904709
## R_cingulate_gyrus_ComputeArea 0.680053587
## R_cingulate_gyrus_Volume 0.673116745
## L_caudate_ComputeArea 0.984408955
## L_caudate_Volume 0.998487141
## R_caudate_ComputeArea 0.805384581
## R_caudate_Volume 0.831340224
## L_putamen_ComputeArea 0.738033991
## L_putamen_Volume 0.782448912
## R_putamen_ComputeArea 0.680702173
## R_putamen_Volume 0.712623611
## L_hippocampus_ComputeArea 0.632227239
## L_hippocampus_Volume 0.658947492
## R_hippocampus_ComputeArea 0.554231176
## R_hippocampus_Volume 0.567836954
## cerebellum_ComputeArea -0.066753474
## cerebellum_Volume 0.093891266
## L_fusiform_gyrus_ComputeArea 0.120008028
## L_fusiform_gyrus_Volume 0.354424866
## R_fusiform_gyrus_ComputeArea 0.207971689
## R_fusiform_gyrus_Volume 0.368922516
## R_fusiform_gyrus_ShapeIndex 0.122623842
## R_fusiform_gyrus_Curvedness -0.086584214
## Sex 0.112050261
## Weight -0.077483696
## RG_ranked 0.085492296
## Age -0.366200718
## chr12_rs34637584_GT 0.081944447
## chr17_rs11868035_GT 0.060021278
## chr17_rs11012_GT -0.004447607
## chr17_rs393152_GT 0.002127973
## chr17_rs12185268_GT 0.007861980
## chr17_rs199533_GT 0.003364080
## UPDRS_Part_I_Summary_Score_Baseline -0.018821910
## UPDRS_Part_I_Summary_Score_Month_03 0.023031425
## UPDRS_Part_I_Summary_Score_Month_06 -0.044948510
## UPDRS_Part_I_Summary_Score_Month_09 -0.097427267
## UPDRS_Part_I_Summary_Score_Month_12 -0.075180771
## UPDRS_Part_I_Summary_Score_Month_18 -0.051921431
## UPDRS_Part_I_Summary_Score_Month_24 -0.073109081
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.027683321
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.025122366
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.038739092
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.062293457
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.013295633
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.018133019
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -0.030337718
## UPDRS_Part_III_Summary_Score_Baseline -0.021935069
## UPDRS_Part_III_Summary_Score_Month_03 -0.055357359
## UPDRS_Part_III_Summary_Score_Month_06 -0.019767175
## UPDRS_Part_III_Summary_Score_Month_09 -0.015264162
## UPDRS_Part_III_Summary_Score_Month_12 0.049854186
## UPDRS_Part_III_Summary_Score_Month_18 0.020288347
## UPDRS_Part_III_Summary_Score_Month_24 -0.006445136
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.042523665
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.090501909
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.085052176
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.056109727
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.043978959
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.064301448
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.005819086
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.021124428
## ctrl -0.063527151
## pd 0.097207419
## swedd -0.064297306
## R_caudate_ComputeArea
## L_insular_cortex_ComputeArea 0.871349351
## L_insular_cortex_Volume 0.875057343
## R_insular_cortex_ComputeArea 0.898624279
## R_insular_cortex_Volume 0.888463302
## L_cingulate_gyrus_ComputeArea 0.879018158
## L_cingulate_gyrus_Volume 0.879142443
## R_cingulate_gyrus_ComputeArea 0.865767334
## R_cingulate_gyrus_Volume 0.863152907
## L_caudate_ComputeArea 0.845776505
## L_caudate_Volume 0.805384581
## R_caudate_ComputeArea 0.998487141
## R_caudate_Volume 0.984585090
## L_putamen_ComputeArea 0.791294568
## L_putamen_Volume 0.795708437
## R_putamen_ComputeArea 0.873992867
## R_putamen_Volume 0.896779785
## L_hippocampus_ComputeArea 0.805805113
## L_hippocampus_Volume 0.824530473
## R_hippocampus_ComputeArea 0.773734546
## R_hippocampus_Volume 0.787977694
## cerebellum_ComputeArea -0.066146263
## cerebellum_Volume 0.111517598
## L_fusiform_gyrus_ComputeArea 0.174058262
## L_fusiform_gyrus_Volume 0.473201252
## R_fusiform_gyrus_ComputeArea 0.255097192
## R_fusiform_gyrus_Volume 0.456478952
## R_fusiform_gyrus_ShapeIndex 0.091490354
## R_fusiform_gyrus_Curvedness -0.094748329
## Sex 0.071757720
## Weight -0.082088384
## RG_ranked 0.089762638
## Age -0.183118336
## chr12_rs34637584_GT 0.055345912
## chr17_rs11868035_GT 0.027328515
## chr17_rs11012_GT 0.014496676
## chr17_rs393152_GT 0.029611437
## chr17_rs12185268_GT 0.035559978
## chr17_rs199533_GT 0.024617145
## UPDRS_Part_I_Summary_Score_Baseline 0.029189264
## UPDRS_Part_I_Summary_Score_Month_03 0.023463652
## UPDRS_Part_I_Summary_Score_Month_06 -0.035800189
## UPDRS_Part_I_Summary_Score_Month_09 -0.026662014
## UPDRS_Part_I_Summary_Score_Month_12 -0.022933628
## UPDRS_Part_I_Summary_Score_Month_18 -0.021415018
## UPDRS_Part_I_Summary_Score_Month_24 -0.023033479
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.060941905
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.033222641
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.014970452
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.041500376
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.006332398
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.005661965
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.017881207
## UPDRS_Part_III_Summary_Score_Baseline 0.029100248
## UPDRS_Part_III_Summary_Score_Month_03 -0.010990040
## UPDRS_Part_III_Summary_Score_Month_06 0.015580681
## UPDRS_Part_III_Summary_Score_Month_09 0.001878212
## UPDRS_Part_III_Summary_Score_Month_12 0.065456820
## UPDRS_Part_III_Summary_Score_Month_18 0.043706381
## UPDRS_Part_III_Summary_Score_Month_24 0.036377236
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.023487989
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.065877218
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.077594278
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.016032522
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.028751022
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.038615991
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.047524471
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.009493237
## ctrl -0.055072416
## pd 0.112682352
## swedd -0.102354567
## R_caudate_Volume
## L_insular_cortex_ComputeArea 8.453146e-01
## L_insular_cortex_Volume 8.597997e-01
## R_insular_cortex_ComputeArea 8.730556e-01
## R_insular_cortex_Volume 8.741899e-01
## L_cingulate_gyrus_ComputeArea 8.705920e-01
## L_cingulate_gyrus_Volume 8.785381e-01
## R_cingulate_gyrus_ComputeArea 8.486484e-01
## R_cingulate_gyrus_Volume 8.531437e-01
## L_caudate_ComputeArea 8.577149e-01
## L_caudate_Volume 8.313402e-01
## R_caudate_ComputeArea 9.845851e-01
## R_caudate_Volume 9.984871e-01
## L_putamen_ComputeArea 7.856866e-01
## L_putamen_Volume 8.019983e-01
## R_putamen_ComputeArea 8.540578e-01
## R_putamen_Volume 8.892321e-01
## L_hippocampus_ComputeArea 7.727843e-01
## L_hippocampus_Volume 7.993800e-01
## R_hippocampus_ComputeArea 7.323300e-01
## R_hippocampus_Volume 7.507443e-01
## cerebellum_ComputeArea -7.482748e-02
## cerebellum_Volume 1.006243e-01
## L_fusiform_gyrus_ComputeArea 1.618025e-01
## L_fusiform_gyrus_Volume 4.539587e-01
## R_fusiform_gyrus_ComputeArea 2.489836e-01
## R_fusiform_gyrus_Volume 4.468741e-01
## R_fusiform_gyrus_ShapeIndex 1.065007e-01
## R_fusiform_gyrus_Curvedness -8.611290e-02
## Sex 7.220246e-02
## Weight -7.494315e-02
## RG_ranked 8.429548e-02
## Age -2.010744e-01
## chr12_rs34637584_GT 5.524005e-02
## chr17_rs11868035_GT 3.493388e-02
## chr17_rs11012_GT 1.759636e-02
## chr17_rs393152_GT 2.532321e-02
## chr17_rs12185268_GT 3.594350e-02
## chr17_rs199533_GT 2.097377e-02
## UPDRS_Part_I_Summary_Score_Baseline 2.152344e-02
## UPDRS_Part_I_Summary_Score_Month_03 2.927347e-02
## UPDRS_Part_I_Summary_Score_Month_06 -3.925121e-02
## UPDRS_Part_I_Summary_Score_Month_09 -3.103120e-02
## UPDRS_Part_I_Summary_Score_Month_12 -2.376464e-02
## UPDRS_Part_I_Summary_Score_Month_18 -1.540844e-02
## UPDRS_Part_I_Summary_Score_Month_24 -2.318698e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 5.521152e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 3.154575e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -2.039489e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -4.421246e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -3.608617e-05
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 4.873309e-03
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 1.206653e-02
## UPDRS_Part_III_Summary_Score_Baseline 1.961786e-02
## UPDRS_Part_III_Summary_Score_Month_03 -1.336355e-02
## UPDRS_Part_III_Summary_Score_Month_06 9.980041e-03
## UPDRS_Part_III_Summary_Score_Month_09 3.608533e-04
## UPDRS_Part_III_Summary_Score_Month_12 6.208008e-02
## UPDRS_Part_III_Summary_Score_Month_18 5.467035e-02
## UPDRS_Part_III_Summary_Score_Month_24 3.442432e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -2.063122e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -6.909706e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -7.135188e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -1.654165e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -4.177768e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 3.072734e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 3.755076e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 5.088451e-03
## ctrl -4.992876e-02
## pd 1.074534e-01
## swedd -1.014827e-01
## L_putamen_ComputeArea
## L_insular_cortex_ComputeArea 0.805305689
## L_insular_cortex_Volume 0.814656792
## R_insular_cortex_ComputeArea 0.809258225
## R_insular_cortex_Volume 0.819169356
## L_cingulate_gyrus_ComputeArea 0.823945008
## L_cingulate_gyrus_Volume 0.819735680
## R_cingulate_gyrus_ComputeArea 0.792352062
## R_cingulate_gyrus_Volume 0.778627549
## L_caudate_ComputeArea 0.756095890
## L_caudate_Volume 0.738033991
## R_caudate_ComputeArea 0.791294568
## R_caudate_Volume 0.785686609
## L_putamen_ComputeArea 0.998487141
## L_putamen_Volume 0.972137787
## R_putamen_ComputeArea 0.823295834
## R_putamen_Volume 0.819500560
## L_hippocampus_ComputeArea 0.700235701
## L_hippocampus_Volume 0.720906459
## R_hippocampus_ComputeArea 0.616925076
## R_hippocampus_Volume 0.636938664
## cerebellum_ComputeArea 0.047042007
## cerebellum_Volume 0.179461920
## L_fusiform_gyrus_ComputeArea 0.228498640
## L_fusiform_gyrus_Volume 0.459798930
## R_fusiform_gyrus_ComputeArea 0.249870900
## R_fusiform_gyrus_Volume 0.414429874
## R_fusiform_gyrus_ShapeIndex 0.122329115
## R_fusiform_gyrus_Curvedness -0.104766838
## Sex 0.068891546
## Weight -0.102267664
## RG_ranked 0.124204874
## Age -0.199731481
## chr12_rs34637584_GT 0.039762913
## chr17_rs11868035_GT 0.061496487
## chr17_rs11012_GT 0.054971531
## chr17_rs393152_GT 0.056272247
## chr17_rs12185268_GT 0.072917888
## chr17_rs199533_GT 0.052137386
## UPDRS_Part_I_Summary_Score_Baseline -0.010436372
## UPDRS_Part_I_Summary_Score_Month_03 -0.013594153
## UPDRS_Part_I_Summary_Score_Month_06 -0.062346965
## UPDRS_Part_I_Summary_Score_Month_09 -0.090418026
## UPDRS_Part_I_Summary_Score_Month_12 -0.063699894
## UPDRS_Part_I_Summary_Score_Month_18 -0.063883654
## UPDRS_Part_I_Summary_Score_Month_24 -0.047324918
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.070940854
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.021363762
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.015609421
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.022211014
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.014123077
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.002271194
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.029839263
## UPDRS_Part_III_Summary_Score_Baseline 0.052597583
## UPDRS_Part_III_Summary_Score_Month_03 -0.019450806
## UPDRS_Part_III_Summary_Score_Month_06 0.001214721
## UPDRS_Part_III_Summary_Score_Month_09 0.039218194
## UPDRS_Part_III_Summary_Score_Month_12 0.097899994
## UPDRS_Part_III_Summary_Score_Month_18 0.044657755
## UPDRS_Part_III_Summary_Score_Month_24 0.073923028
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.074954686
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.096679116
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.088400059
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.042360034
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.055312222
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.010641773
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.007799782
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.030333065
## ctrl -0.096507429
## pd 0.137376366
## swedd -0.080784365
## L_putamen_Volume
## L_insular_cortex_ComputeArea 0.797139538
## L_insular_cortex_Volume 0.820014318
## R_insular_cortex_ComputeArea 0.811040899
## R_insular_cortex_Volume 0.836018563
## L_cingulate_gyrus_ComputeArea 0.829323702
## L_cingulate_gyrus_Volume 0.836924895
## R_cingulate_gyrus_ComputeArea 0.792176926
## R_cingulate_gyrus_Volume 0.788450579
## L_caudate_ComputeArea 0.788759391
## L_caudate_Volume 0.782448912
## R_caudate_ComputeArea 0.795708437
## R_caudate_Volume 0.801998253
## L_putamen_ComputeArea 0.972137787
## L_putamen_Volume 0.998487141
## R_putamen_ComputeArea 0.800751105
## R_putamen_Volume 0.818305443
## L_hippocampus_ComputeArea 0.691683884
## L_hippocampus_Volume 0.719771453
## R_hippocampus_ComputeArea 0.601444639
## R_hippocampus_Volume 0.623496007
## cerebellum_ComputeArea 0.001967161
## cerebellum_Volume 0.150399559
## L_fusiform_gyrus_ComputeArea 0.190956473
## L_fusiform_gyrus_Volume 0.435342920
## R_fusiform_gyrus_ComputeArea 0.240728494
## R_fusiform_gyrus_Volume 0.411246891
## R_fusiform_gyrus_ShapeIndex 0.125614256
## R_fusiform_gyrus_Curvedness -0.104717423
## Sex 0.050966604
## Weight -0.089561749
## RG_ranked 0.126572610
## Age -0.213794616
## chr12_rs34637584_GT 0.038651899
## chr17_rs11868035_GT 0.073689860
## chr17_rs11012_GT 0.050860690
## chr17_rs393152_GT 0.053512412
## chr17_rs12185268_GT 0.065470184
## chr17_rs199533_GT 0.038236619
## UPDRS_Part_I_Summary_Score_Baseline -0.013521674
## UPDRS_Part_I_Summary_Score_Month_03 -0.017938661
## UPDRS_Part_I_Summary_Score_Month_06 -0.055049516
## UPDRS_Part_I_Summary_Score_Month_09 -0.088272810
## UPDRS_Part_I_Summary_Score_Month_12 -0.062243345
## UPDRS_Part_I_Summary_Score_Month_18 -0.061305591
## UPDRS_Part_I_Summary_Score_Month_24 -0.044200184
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.075109837
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.035098673
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.016991459
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.015605993
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.024331083
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.006709320
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.041173853
## UPDRS_Part_III_Summary_Score_Baseline 0.057642359
## UPDRS_Part_III_Summary_Score_Month_03 -0.023925643
## UPDRS_Part_III_Summary_Score_Month_06 -0.000539180
## UPDRS_Part_III_Summary_Score_Month_09 0.045245323
## UPDRS_Part_III_Summary_Score_Month_12 0.108824626
## UPDRS_Part_III_Summary_Score_Month_18 0.061474397
## UPDRS_Part_III_Summary_Score_Month_24 0.081332044
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.069655514
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.106946349
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.093138707
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.047394360
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.061847521
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.007045567
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.008594726
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.029972182
## ctrl -0.101723116
## pd 0.136912041
## swedd -0.072207592
## R_putamen_ComputeArea
## L_insular_cortex_ComputeArea 0.861717828
## L_insular_cortex_Volume 0.853732787
## R_insular_cortex_ComputeArea 0.876832464
## R_insular_cortex_Volume 0.861234001
## L_cingulate_gyrus_ComputeArea 0.863380763
## L_cingulate_gyrus_Volume 0.856386446
## R_cingulate_gyrus_ComputeArea 0.847118415
## R_cingulate_gyrus_Volume 0.837866652
## L_caudate_ComputeArea 0.723370623
## L_caudate_Volume 0.680702173
## R_caudate_ComputeArea 0.873992867
## R_caudate_Volume 0.854057777
## L_putamen_ComputeArea 0.823295834
## L_putamen_Volume 0.800751105
## R_putamen_ComputeArea 0.998487141
## R_putamen_Volume 0.977587254
## L_hippocampus_ComputeArea 0.778009039
## L_hippocampus_Volume 0.795197248
## R_hippocampus_ComputeArea 0.735504923
## R_hippocampus_Volume 0.750503276
## cerebellum_ComputeArea 0.018571228
## cerebellum_Volume 0.163201680
## L_fusiform_gyrus_ComputeArea 0.181081646
## L_fusiform_gyrus_Volume 0.463779229
## R_fusiform_gyrus_ComputeArea 0.251745300
## R_fusiform_gyrus_Volume 0.436200511
## R_fusiform_gyrus_ShapeIndex 0.113064797
## R_fusiform_gyrus_Curvedness -0.111210277
## Sex 0.012409973
## Weight -0.075057710
## RG_ranked 0.114034741
## Age -0.114725809
## chr12_rs34637584_GT 0.041993471
## chr17_rs11868035_GT 0.006186830
## chr17_rs11012_GT 0.002875608
## chr17_rs393152_GT 0.018313473
## chr17_rs12185268_GT 0.023181630
## chr17_rs199533_GT 0.015994886
## UPDRS_Part_I_Summary_Score_Baseline 0.023604875
## UPDRS_Part_I_Summary_Score_Month_03 0.012134957
## UPDRS_Part_I_Summary_Score_Month_06 -0.056290667
## UPDRS_Part_I_Summary_Score_Month_09 -0.043788660
## UPDRS_Part_I_Summary_Score_Month_12 -0.032318973
## UPDRS_Part_I_Summary_Score_Month_18 -0.026289168
## UPDRS_Part_I_Summary_Score_Month_24 -0.012942248
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.073750919
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.030329230
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.038680078
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.005451005
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.038045404
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.021429157
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.040589370
## UPDRS_Part_III_Summary_Score_Baseline 0.074462416
## UPDRS_Part_III_Summary_Score_Month_03 0.015508620
## UPDRS_Part_III_Summary_Score_Month_06 0.050446513
## UPDRS_Part_III_Summary_Score_Month_09 0.057056281
## UPDRS_Part_III_Summary_Score_Month_12 0.096904461
## UPDRS_Part_III_Summary_Score_Month_18 0.041061404
## UPDRS_Part_III_Summary_Score_Month_24 0.074552833
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.053281398
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.067724221
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.066065666
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.008364588
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.023246790
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.013845451
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.022941261
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.021378005
## ctrl -0.085595017
## pd 0.128876849
## swedd -0.083190310
## R_putamen_Volume
## L_insular_cortex_ComputeArea 0.864351779
## L_insular_cortex_Volume 0.866698797
## R_insular_cortex_ComputeArea 0.887203280
## R_insular_cortex_Volume 0.880966404
## L_cingulate_gyrus_ComputeArea 0.880255152
## L_cingulate_gyrus_Volume 0.884117351
## R_cingulate_gyrus_ComputeArea 0.857464946
## R_cingulate_gyrus_Volume 0.856889128
## L_caudate_ComputeArea 0.749523164
## L_caudate_Volume 0.712623611
## R_caudate_ComputeArea 0.896779785
## R_caudate_Volume 0.889232141
## L_putamen_ComputeArea 0.819500560
## L_putamen_Volume 0.818305443
## R_putamen_ComputeArea 0.977587254
## R_putamen_Volume 0.998487141
## L_hippocampus_ComputeArea 0.785661891
## L_hippocampus_Volume 0.809481677
## R_hippocampus_ComputeArea 0.738600401
## R_hippocampus_Volume 0.756867241
## cerebellum_ComputeArea -0.010717405
## cerebellum_Volume 0.148168623
## L_fusiform_gyrus_ComputeArea 0.163413838
## L_fusiform_gyrus_Volume 0.456597803
## R_fusiform_gyrus_ComputeArea 0.242756062
## R_fusiform_gyrus_Volume 0.438104749
## R_fusiform_gyrus_ShapeIndex 0.102124337
## R_fusiform_gyrus_Curvedness -0.107126451
## Sex 0.004271114
## Weight -0.072761609
## RG_ranked 0.108638682
## Age -0.121789860
## chr12_rs34637584_GT 0.040667286
## chr17_rs11868035_GT 0.014886742
## chr17_rs11012_GT 0.016124941
## chr17_rs393152_GT 0.027399340
## chr17_rs12185268_GT 0.033537483
## chr17_rs199533_GT 0.024132981
## UPDRS_Part_I_Summary_Score_Baseline 0.017981538
## UPDRS_Part_I_Summary_Score_Month_03 0.002929853
## UPDRS_Part_I_Summary_Score_Month_06 -0.055825859
## UPDRS_Part_I_Summary_Score_Month_09 -0.039584626
## UPDRS_Part_I_Summary_Score_Month_12 -0.030155907
## UPDRS_Part_I_Summary_Score_Month_18 -0.023632424
## UPDRS_Part_I_Summary_Score_Month_24 -0.018134402
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.069115198
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.028199408
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.029168627
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.004348351
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.031609801
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.017126652
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.038421192
## UPDRS_Part_III_Summary_Score_Baseline 0.065456286
## UPDRS_Part_III_Summary_Score_Month_03 0.013247415
## UPDRS_Part_III_Summary_Score_Month_06 0.042409008
## UPDRS_Part_III_Summary_Score_Month_09 0.045385261
## UPDRS_Part_III_Summary_Score_Month_12 0.092900538
## UPDRS_Part_III_Summary_Score_Month_18 0.050703043
## UPDRS_Part_III_Summary_Score_Month_24 0.071366121
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.060196797
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.080988740
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.082560111
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.020643648
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.032214239
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.006467705
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.025542464
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.018638860
## ctrl -0.076695602
## pd 0.127207011
## swedd -0.093785207
## L_hippocampus_ComputeArea
## L_insular_cortex_ComputeArea 0.858451786
## L_insular_cortex_Volume 0.842764032
## R_insular_cortex_ComputeArea 0.863572136
## R_insular_cortex_Volume 0.844062771
## L_cingulate_gyrus_ComputeArea 0.815712913
## L_cingulate_gyrus_Volume 0.811480047
## R_cingulate_gyrus_ComputeArea 0.810807188
## R_cingulate_gyrus_Volume 0.812009097
## L_caudate_ComputeArea 0.681469515
## L_caudate_Volume 0.632227239
## R_caudate_ComputeArea 0.805805113
## R_caudate_Volume 0.772784338
## L_putamen_ComputeArea 0.700235701
## L_putamen_Volume 0.691683884
## R_putamen_ComputeArea 0.778009039
## R_putamen_Volume 0.785661891
## L_hippocampus_ComputeArea 0.998487141
## L_hippocampus_Volume 0.984486544
## R_hippocampus_ComputeArea 0.856473915
## R_hippocampus_Volume 0.858841369
## cerebellum_ComputeArea 0.102712057
## cerebellum_Volume 0.288542261
## L_fusiform_gyrus_ComputeArea 0.355144094
## L_fusiform_gyrus_Volume 0.631508533
## R_fusiform_gyrus_ComputeArea 0.357954144
## R_fusiform_gyrus_Volume 0.549347459
## R_fusiform_gyrus_ShapeIndex 0.158461561
## R_fusiform_gyrus_Curvedness -0.107955502
## Sex -0.057508976
## Weight 0.007020847
## RG_ranked 0.086837960
## Age -0.100885625
## chr12_rs34637584_GT 0.033748058
## chr17_rs11868035_GT 0.024858655
## chr17_rs11012_GT 0.022983001
## chr17_rs393152_GT 0.036077041
## chr17_rs12185268_GT 0.016648918
## chr17_rs199533_GT 0.011177098
## UPDRS_Part_I_Summary_Score_Baseline 0.002561930
## UPDRS_Part_I_Summary_Score_Month_03 0.013821106
## UPDRS_Part_I_Summary_Score_Month_06 -0.078420143
## UPDRS_Part_I_Summary_Score_Month_09 -0.065198729
## UPDRS_Part_I_Summary_Score_Month_12 -0.043498423
## UPDRS_Part_I_Summary_Score_Month_18 -0.042537386
## UPDRS_Part_I_Summary_Score_Month_24 -0.041064037
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.076911214
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.023216951
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.037001804
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.005987207
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.037829073
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.049456286
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.051657486
## UPDRS_Part_III_Summary_Score_Baseline 0.059319999
## UPDRS_Part_III_Summary_Score_Month_03 0.022000458
## UPDRS_Part_III_Summary_Score_Month_06 0.035378737
## UPDRS_Part_III_Summary_Score_Month_09 0.018290710
## UPDRS_Part_III_Summary_Score_Month_12 0.078592972
## UPDRS_Part_III_Summary_Score_Month_18 0.075629413
## UPDRS_Part_III_Summary_Score_Month_24 0.102191551
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.043559434
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.064073105
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.088166228
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.035179962
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.029536521
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.002166421
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.045509917
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.021963642
## ctrl -0.057322069
## pd 0.105317598
## swedd -0.086900755
## L_hippocampus_Volume
## L_insular_cortex_ComputeArea 0.866763777
## L_insular_cortex_Volume 0.862093394
## R_insular_cortex_ComputeArea 0.873728530
## R_insular_cortex_Volume 0.863541500
## L_cingulate_gyrus_ComputeArea 0.832011305
## L_cingulate_gyrus_Volume 0.834783913
## R_cingulate_gyrus_ComputeArea 0.824134693
## R_cingulate_gyrus_Volume 0.832047972
## L_caudate_ComputeArea 0.703078314
## L_caudate_Volume 0.658947492
## R_caudate_ComputeArea 0.824530473
## R_caudate_Volume 0.799379970
## L_putamen_ComputeArea 0.720906459
## L_putamen_Volume 0.719771453
## R_putamen_ComputeArea 0.795197248
## R_putamen_Volume 0.809481677
## L_hippocampus_ComputeArea 0.984486544
## L_hippocampus_Volume 0.998487141
## R_hippocampus_ComputeArea 0.847140137
## R_hippocampus_Volume 0.864961532
## cerebellum_ComputeArea 0.066847635
## cerebellum_Volume 0.263113299
## L_fusiform_gyrus_ComputeArea 0.318720043
## L_fusiform_gyrus_Volume 0.617155549
## R_fusiform_gyrus_ComputeArea 0.340435679
## R_fusiform_gyrus_Volume 0.547860135
## R_fusiform_gyrus_ShapeIndex 0.139701809
## R_fusiform_gyrus_Curvedness -0.103527615
## Sex -0.073131070
## Weight 0.013030582
## RG_ranked 0.080774798
## Age -0.102843218
## chr12_rs34637584_GT 0.025271251
## chr17_rs11868035_GT 0.031736981
## chr17_rs11012_GT 0.026703621
## chr17_rs393152_GT 0.036034881
## chr17_rs12185268_GT 0.023652813
## chr17_rs199533_GT 0.015321394
## UPDRS_Part_I_Summary_Score_Baseline -0.012904372
## UPDRS_Part_I_Summary_Score_Month_03 0.002647328
## UPDRS_Part_I_Summary_Score_Month_06 -0.084948626
## UPDRS_Part_I_Summary_Score_Month_09 -0.066474377
## UPDRS_Part_I_Summary_Score_Month_12 -0.049947198
## UPDRS_Part_I_Summary_Score_Month_18 -0.045142073
## UPDRS_Part_I_Summary_Score_Month_24 -0.055002700
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.072290135
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.024423344
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.034239281
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.006176881
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.033369136
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.054356708
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.048314014
## UPDRS_Part_III_Summary_Score_Baseline 0.053826185
## UPDRS_Part_III_Summary_Score_Month_03 0.026565421
## UPDRS_Part_III_Summary_Score_Month_06 0.032072260
## UPDRS_Part_III_Summary_Score_Month_09 0.018551838
## UPDRS_Part_III_Summary_Score_Month_12 0.079532311
## UPDRS_Part_III_Summary_Score_Month_18 0.089504679
## UPDRS_Part_III_Summary_Score_Month_24 0.099331026
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.048764330
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.066763508
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.091897056
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.037477481
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.035117469
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.009633582
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.034645545
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.014736367
## ctrl -0.048559265
## pd 0.102311765
## swedd -0.095099054
## R_hippocampus_ComputeArea
## L_insular_cortex_ComputeArea 0.796504324
## L_insular_cortex_Volume 0.773481420
## R_insular_cortex_ComputeArea 0.829444139
## R_insular_cortex_Volume 0.797259090
## L_cingulate_gyrus_ComputeArea 0.742197042
## L_cingulate_gyrus_Volume 0.735233060
## R_cingulate_gyrus_ComputeArea 0.755550718
## R_cingulate_gyrus_Volume 0.755383440
## L_caudate_ComputeArea 0.606960336
## L_caudate_Volume 0.554231176
## R_caudate_ComputeArea 0.773734546
## R_caudate_Volume 0.732330004
## L_putamen_ComputeArea 0.616925076
## L_putamen_Volume 0.601444639
## R_putamen_ComputeArea 0.735504923
## R_putamen_Volume 0.738600401
## L_hippocampus_ComputeArea 0.856473915
## L_hippocampus_Volume 0.847140137
## R_hippocampus_ComputeArea 0.998487141
## R_hippocampus_Volume 0.982340097
## cerebellum_ComputeArea 0.080089904
## cerebellum_Volume 0.280683370
## L_fusiform_gyrus_ComputeArea 0.277057247
## L_fusiform_gyrus_Volume 0.561039775
## R_fusiform_gyrus_ComputeArea 0.427553636
## R_fusiform_gyrus_Volume 0.613490539
## R_fusiform_gyrus_ShapeIndex 0.160487808
## R_fusiform_gyrus_Curvedness 0.023170064
## Sex -0.040111714
## Weight -0.019794887
## RG_ranked 0.099125895
## Age -0.116716025
## chr12_rs34637584_GT 0.034260471
## chr17_rs11868035_GT 0.020180589
## chr17_rs11012_GT 0.015830999
## chr17_rs393152_GT 0.034020883
## chr17_rs12185268_GT 0.015377216
## chr17_rs199533_GT 0.021759185
## UPDRS_Part_I_Summary_Score_Baseline 0.007330644
## UPDRS_Part_I_Summary_Score_Month_03 0.003911327
## UPDRS_Part_I_Summary_Score_Month_06 -0.035395949
## UPDRS_Part_I_Summary_Score_Month_09 -0.004018629
## UPDRS_Part_I_Summary_Score_Month_12 -0.003216987
## UPDRS_Part_I_Summary_Score_Month_18 -0.037814827
## UPDRS_Part_I_Summary_Score_Month_24 -0.042316886
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.084116693
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.046170378
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.038284263
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.020002146
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.049838635
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.053521853
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.060168458
## UPDRS_Part_III_Summary_Score_Baseline 0.056526227
## UPDRS_Part_III_Summary_Score_Month_03 0.028967130
## UPDRS_Part_III_Summary_Score_Month_06 0.038746061
## UPDRS_Part_III_Summary_Score_Month_09 0.006912613
## UPDRS_Part_III_Summary_Score_Month_12 0.073493618
## UPDRS_Part_III_Summary_Score_Month_18 0.042697047
## UPDRS_Part_III_Summary_Score_Month_24 0.070484596
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.062808691
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.092266615
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.076313166
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.048227061
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.063220710
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.032972742
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.063518265
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.056000766
## ctrl -0.058081232
## pd 0.126934971
## swedd -0.121229906
## R_hippocampus_Volume
## L_insular_cortex_ComputeArea 0.8095710582
## L_insular_cortex_Volume 0.7915917048
## R_insular_cortex_ComputeArea 0.8327306747
## R_insular_cortex_Volume 0.8060367138
## L_cingulate_gyrus_ComputeArea 0.7563140023
## L_cingulate_gyrus_Volume 0.7531901447
## R_cingulate_gyrus_ComputeArea 0.7675615036
## R_cingulate_gyrus_Volume 0.7725353548
## L_caudate_ComputeArea 0.6191830875
## L_caudate_Volume 0.5678369540
## R_caudate_ComputeArea 0.7879776937
## R_caudate_Volume 0.7507443151
## L_putamen_ComputeArea 0.6369386639
## L_putamen_Volume 0.6234960068
## R_putamen_ComputeArea 0.7505032764
## R_putamen_Volume 0.7568672409
## L_hippocampus_ComputeArea 0.8588413691
## L_hippocampus_Volume 0.8649615315
## R_hippocampus_ComputeArea 0.9823400966
## R_hippocampus_Volume 0.9984871407
## cerebellum_ComputeArea 0.0508673696
## cerebellum_Volume 0.2548154821
## L_fusiform_gyrus_ComputeArea 0.2657610161
## L_fusiform_gyrus_Volume 0.5639157834
## R_fusiform_gyrus_ComputeArea 0.4052301629
## R_fusiform_gyrus_Volume 0.6093837890
## R_fusiform_gyrus_ShapeIndex 0.1352955217
## R_fusiform_gyrus_Curvedness 0.0443408791
## Sex -0.0595385652
## Weight -0.0076844735
## RG_ranked 0.0921956845
## Age -0.1115987183
## chr12_rs34637584_GT 0.0237135971
## chr17_rs11868035_GT 0.0247177216
## chr17_rs11012_GT 0.0247158979
## chr17_rs393152_GT 0.0375440776
## chr17_rs12185268_GT 0.0250848287
## chr17_rs199533_GT 0.0286894750
## UPDRS_Part_I_Summary_Score_Baseline -0.0001511590
## UPDRS_Part_I_Summary_Score_Month_03 -0.0003478357
## UPDRS_Part_I_Summary_Score_Month_06 -0.0424583961
## UPDRS_Part_I_Summary_Score_Month_09 -0.0086475737
## UPDRS_Part_I_Summary_Score_Month_12 -0.0109707365
## UPDRS_Part_I_Summary_Score_Month_18 -0.0373504029
## UPDRS_Part_I_Summary_Score_Month_24 -0.0429327360
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0815620000
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0484293665
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0361997919
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0142002094
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0488820429
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0542379211
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0589028487
## UPDRS_Part_III_Summary_Score_Baseline 0.0514487433
## UPDRS_Part_III_Summary_Score_Month_03 0.0298471231
## UPDRS_Part_III_Summary_Score_Month_06 0.0291208845
## UPDRS_Part_III_Summary_Score_Month_09 0.0029068024
## UPDRS_Part_III_Summary_Score_Month_12 0.0723017138
## UPDRS_Part_III_Summary_Score_Month_18 0.0488568406
## UPDRS_Part_III_Summary_Score_Month_24 0.0671364300
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0538011619
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0816475357
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0706036647
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0426702252
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0603235090
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0272472219
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0570812931
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0484958436
## ctrl -0.0530438956
## pd 0.1189525193
## swedd -0.1156811999
## cerebellum_ComputeArea
## L_insular_cortex_ComputeArea 8.296883e-02
## L_insular_cortex_Volume 4.559123e-02
## R_insular_cortex_ComputeArea 2.598771e-02
## R_insular_cortex_Volume -1.159555e-03
## L_cingulate_gyrus_ComputeArea 2.994816e-02
## L_cingulate_gyrus_Volume -1.827810e-03
## R_cingulate_gyrus_ComputeArea 2.203188e-02
## R_cingulate_gyrus_Volume -1.018236e-02
## L_caudate_ComputeArea -5.894754e-02
## L_caudate_Volume -6.675347e-02
## R_caudate_ComputeArea -6.614626e-02
## R_caudate_Volume -7.482748e-02
## L_putamen_ComputeArea 4.704201e-02
## L_putamen_Volume 1.967161e-03
## R_putamen_ComputeArea 1.857123e-02
## R_putamen_Volume -1.071741e-02
## L_hippocampus_ComputeArea 1.027121e-01
## L_hippocampus_Volume 6.684763e-02
## R_hippocampus_ComputeArea 8.008990e-02
## R_hippocampus_Volume 5.086737e-02
## cerebellum_ComputeArea 9.984871e-01
## cerebellum_Volume 9.002004e-01
## L_fusiform_gyrus_ComputeArea 5.534802e-01
## L_fusiform_gyrus_Volume 4.407081e-01
## R_fusiform_gyrus_ComputeArea 4.569381e-01
## R_fusiform_gyrus_Volume 3.410662e-01
## R_fusiform_gyrus_ShapeIndex 2.576315e-01
## R_fusiform_gyrus_Curvedness -6.948893e-02
## Sex -1.065054e-01
## Weight -3.223215e-02
## RG_ranked 3.224600e-02
## Age 2.470487e-02
## chr12_rs34637584_GT 4.110819e-02
## chr17_rs11868035_GT -3.164099e-02
## chr17_rs11012_GT -6.156917e-05
## chr17_rs393152_GT 5.685117e-03
## chr17_rs12185268_GT 3.032688e-03
## chr17_rs199533_GT -1.154941e-02
## UPDRS_Part_I_Summary_Score_Baseline -3.805760e-02
## UPDRS_Part_I_Summary_Score_Month_03 -3.108744e-02
## UPDRS_Part_I_Summary_Score_Month_06 -6.771494e-02
## UPDRS_Part_I_Summary_Score_Month_09 -7.099502e-02
## UPDRS_Part_I_Summary_Score_Month_12 -2.342674e-02
## UPDRS_Part_I_Summary_Score_Month_18 -2.347188e-02
## UPDRS_Part_I_Summary_Score_Month_24 -4.269703e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 5.526321e-04
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 3.689278e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 5.880044e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 5.516156e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 4.704854e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 6.042032e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 4.172788e-02
## UPDRS_Part_III_Summary_Score_Baseline 1.829069e-02
## UPDRS_Part_III_Summary_Score_Month_03 3.893080e-02
## UPDRS_Part_III_Summary_Score_Month_06 3.578820e-03
## UPDRS_Part_III_Summary_Score_Month_09 1.394705e-02
## UPDRS_Part_III_Summary_Score_Month_12 3.956743e-02
## UPDRS_Part_III_Summary_Score_Month_18 2.180230e-02
## UPDRS_Part_III_Summary_Score_Month_24 5.273607e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 6.097801e-03
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 4.888855e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 1.318396e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 5.704053e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -4.179381e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -5.689063e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -2.855730e-03
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 4.315485e-03
## ctrl -1.026082e-02
## pd 4.917684e-02
## swedd -6.530782e-02
## cerebellum_Volume
## L_insular_cortex_ComputeArea 0.2537187142
## L_insular_cortex_Volume 0.2218258303
## R_insular_cortex_ComputeArea 0.2167639730
## R_insular_cortex_Volume 0.1943536235
## L_cingulate_gyrus_ComputeArea 0.1900965726
## L_cingulate_gyrus_Volume 0.1685617145
## R_cingulate_gyrus_ComputeArea 0.1829883911
## R_cingulate_gyrus_Volume 0.1638046632
## L_caudate_ComputeArea 0.1080583743
## L_caudate_Volume 0.0938912656
## R_caudate_ComputeArea 0.1115175978
## R_caudate_Volume 0.1006242965
## L_putamen_ComputeArea 0.1794619196
## L_putamen_Volume 0.1503995590
## R_putamen_ComputeArea 0.1632016803
## R_putamen_Volume 0.1481686227
## L_hippocampus_ComputeArea 0.2885422614
## L_hippocampus_Volume 0.2631132986
## R_hippocampus_ComputeArea 0.2806833704
## R_hippocampus_Volume 0.2548154821
## cerebellum_ComputeArea 0.9002003656
## cerebellum_Volume 0.9984871407
## L_fusiform_gyrus_ComputeArea 0.5475399819
## L_fusiform_gyrus_Volume 0.5370021059
## R_fusiform_gyrus_ComputeArea 0.5398678221
## R_fusiform_gyrus_Volume 0.4889287663
## R_fusiform_gyrus_ShapeIndex 0.2715719547
## R_fusiform_gyrus_Curvedness -0.0766204554
## Sex -0.0641917379
## Weight -0.0493491190
## RG_ranked 0.0521825011
## Age -0.0524653785
## chr12_rs34637584_GT 0.0468097004
## chr17_rs11868035_GT 0.0016986981
## chr17_rs11012_GT 0.0077920674
## chr17_rs393152_GT 0.0124076314
## chr17_rs12185268_GT 0.0062140284
## chr17_rs199533_GT 0.0005910261
## UPDRS_Part_I_Summary_Score_Baseline -0.0345374250
## UPDRS_Part_I_Summary_Score_Month_03 -0.0168181728
## UPDRS_Part_I_Summary_Score_Month_06 -0.0758750278
## UPDRS_Part_I_Summary_Score_Month_09 -0.0879970840
## UPDRS_Part_I_Summary_Score_Month_12 -0.0542630808
## UPDRS_Part_I_Summary_Score_Month_18 -0.0384924728
## UPDRS_Part_I_Summary_Score_Month_24 -0.0729314999
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0228641729
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0488823041
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0692317944
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0561829211
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0533779606
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0760079568
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0465477358
## UPDRS_Part_III_Summary_Score_Baseline 0.0109830395
## UPDRS_Part_III_Summary_Score_Month_03 0.0135594478
## UPDRS_Part_III_Summary_Score_Month_06 -0.0145259247
## UPDRS_Part_III_Summary_Score_Month_09 -0.0030070310
## UPDRS_Part_III_Summary_Score_Month_12 0.0434435071
## UPDRS_Part_III_Summary_Score_Month_18 0.0310907047
## UPDRS_Part_III_Summary_Score_Month_24 0.0505696303
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0137251360
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0175219077
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0237108248
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.0470029198
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0598661473
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0531788376
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0079848829
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0180607587
## ctrl -0.0178425396
## pd 0.0784505592
## swedd -0.1019757542
## L_fusiform_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.2557427821
## L_insular_cortex_Volume 0.2162676452
## R_insular_cortex_ComputeArea 0.2461304317
## R_insular_cortex_Volume 0.2067216352
## L_cingulate_gyrus_ComputeArea 0.2720120446
## L_cingulate_gyrus_Volume 0.2342750858
## R_cingulate_gyrus_ComputeArea 0.2853478192
## R_cingulate_gyrus_Volume 0.2553356152
## L_caudate_ComputeArea 0.1458458134
## L_caudate_Volume 0.1200080283
## R_caudate_ComputeArea 0.1740582618
## R_caudate_Volume 0.1618024510
## L_putamen_ComputeArea 0.2284986399
## L_putamen_Volume 0.1909564732
## R_putamen_ComputeArea 0.1810816455
## R_putamen_Volume 0.1634138379
## L_hippocampus_ComputeArea 0.3551440936
## L_hippocampus_Volume 0.3187200427
## R_hippocampus_ComputeArea 0.2770572475
## R_hippocampus_Volume 0.2657610161
## cerebellum_ComputeArea 0.5534802073
## cerebellum_Volume 0.5475399819
## L_fusiform_gyrus_ComputeArea 0.9984871407
## L_fusiform_gyrus_Volume 0.9013552122
## R_fusiform_gyrus_ComputeArea 0.4969577785
## R_fusiform_gyrus_Volume 0.4663368435
## R_fusiform_gyrus_ShapeIndex 0.2266270209
## R_fusiform_gyrus_Curvedness -0.0805789598
## Sex -0.1117174649
## Weight 0.0235796554
## RG_ranked 0.0450667970
## Age -0.0441303678
## chr12_rs34637584_GT 0.0510724715
## chr17_rs11868035_GT -0.0090398735
## chr17_rs11012_GT 0.0084152240
## chr17_rs393152_GT -0.0016871224
## chr17_rs12185268_GT 0.0040783463
## chr17_rs199533_GT 0.0053835459
## UPDRS_Part_I_Summary_Score_Baseline 0.0086240919
## UPDRS_Part_I_Summary_Score_Month_03 -0.0473568286
## UPDRS_Part_I_Summary_Score_Month_06 -0.0283910478
## UPDRS_Part_I_Summary_Score_Month_09 -0.0784501999
## UPDRS_Part_I_Summary_Score_Month_12 -0.0117877370
## UPDRS_Part_I_Summary_Score_Month_18 -0.0129090453
## UPDRS_Part_I_Summary_Score_Month_24 -0.0181291348
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline -0.0385859844
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 -0.0086705634
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.0046912361
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0063891890
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0003985807
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.0072268837
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0038411980
## UPDRS_Part_III_Summary_Score_Baseline 0.0349874393
## UPDRS_Part_III_Summary_Score_Month_03 0.0245021345
## UPDRS_Part_III_Summary_Score_Month_06 0.0346067937
## UPDRS_Part_III_Summary_Score_Month_09 -0.0030641570
## UPDRS_Part_III_Summary_Score_Month_12 0.0440024522
## UPDRS_Part_III_Summary_Score_Month_18 0.0131610496
## UPDRS_Part_III_Summary_Score_Month_24 0.0535322625
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0198683605
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0207068192
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0555136425
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0290442589
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0402672366
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0224815803
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0127138567
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0279824823
## ctrl -0.0449138342
## pd 0.0408074886
## swedd 0.0003460741
## L_fusiform_gyrus_Volume
## L_insular_cortex_ComputeArea 0.5521876527
## L_insular_cortex_Volume 0.5229263479
## R_insular_cortex_ComputeArea 0.5480899265
## R_insular_cortex_Volume 0.5129586011
## L_cingulate_gyrus_ComputeArea 0.5466827119
## L_cingulate_gyrus_Volume 0.5226112717
## R_cingulate_gyrus_ComputeArea 0.5621744065
## R_cingulate_gyrus_Volume 0.5473278372
## L_caudate_ComputeArea 0.3945446740
## L_caudate_Volume 0.3544248656
## R_caudate_ComputeArea 0.4732012524
## R_caudate_Volume 0.4539587436
## L_putamen_ComputeArea 0.4597989305
## L_putamen_Volume 0.4353429202
## R_putamen_ComputeArea 0.4637792287
## R_putamen_Volume 0.4565978025
## L_hippocampus_ComputeArea 0.6315085332
## L_hippocampus_Volume 0.6171555493
## R_hippocampus_ComputeArea 0.5610397751
## R_hippocampus_Volume 0.5639157834
## cerebellum_ComputeArea 0.4407080606
## cerebellum_Volume 0.5370021059
## L_fusiform_gyrus_ComputeArea 0.9013552122
## L_fusiform_gyrus_Volume 0.9984871407
## R_fusiform_gyrus_ComputeArea 0.5234830021
## R_fusiform_gyrus_Volume 0.6056916364
## R_fusiform_gyrus_ShapeIndex 0.2110861904
## R_fusiform_gyrus_Curvedness -0.1047270675
## Sex -0.1393547562
## Weight 0.0412653919
## RG_ranked 0.0808508254
## Age -0.0904546024
## chr12_rs34637584_GT 0.0471693026
## chr17_rs11868035_GT 0.0190516326
## chr17_rs11012_GT 0.0144802921
## chr17_rs393152_GT 0.0139521159
## chr17_rs12185268_GT 0.0183979392
## chr17_rs199533_GT 0.0185341903
## UPDRS_Part_I_Summary_Score_Baseline 0.0144854955
## UPDRS_Part_I_Summary_Score_Month_03 -0.0347247027
## UPDRS_Part_I_Summary_Score_Month_06 -0.0536401763
## UPDRS_Part_I_Summary_Score_Month_09 -0.0788852663
## UPDRS_Part_I_Summary_Score_Month_12 -0.0174008569
## UPDRS_Part_I_Summary_Score_Month_18 -0.0196150715
## UPDRS_Part_I_Summary_Score_Month_24 -0.0293136537
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline -0.0003699554
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0101302262
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0071648006
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0026615357
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0198189920
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0127246775
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0282049932
## UPDRS_Part_III_Summary_Score_Baseline 0.0578968395
## UPDRS_Part_III_Summary_Score_Month_03 0.0251052629
## UPDRS_Part_III_Summary_Score_Month_06 0.0382068726
## UPDRS_Part_III_Summary_Score_Month_09 0.0102226325
## UPDRS_Part_III_Summary_Score_Month_12 0.0692907030
## UPDRS_Part_III_Summary_Score_Month_18 0.0413499139
## UPDRS_Part_III_Summary_Score_Month_24 0.0741800971
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0223693611
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0042051581
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0645591632
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0083181425
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0526418342
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0229715295
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0156279778
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0115711392
## ctrl -0.0661991040
## pd 0.0863398816
## swedd -0.0424638797
## R_fusiform_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 3.232958e-01
## L_insular_cortex_Volume 2.999868e-01
## R_insular_cortex_ComputeArea 3.496695e-01
## R_insular_cortex_Volume 3.281261e-01
## L_cingulate_gyrus_ComputeArea 3.339099e-01
## L_cingulate_gyrus_Volume 3.132764e-01
## R_cingulate_gyrus_ComputeArea 3.281291e-01
## R_cingulate_gyrus_Volume 3.106909e-01
## L_caudate_ComputeArea 2.212751e-01
## L_caudate_Volume 2.079717e-01
## R_caudate_ComputeArea 2.550972e-01
## R_caudate_Volume 2.489836e-01
## L_putamen_ComputeArea 2.498709e-01
## L_putamen_Volume 2.407285e-01
## R_putamen_ComputeArea 2.517453e-01
## R_putamen_Volume 2.427561e-01
## L_hippocampus_ComputeArea 3.579541e-01
## L_hippocampus_Volume 3.404357e-01
## R_hippocampus_ComputeArea 4.275536e-01
## R_hippocampus_Volume 4.052302e-01
## cerebellum_ComputeArea 4.569381e-01
## cerebellum_Volume 5.398678e-01
## L_fusiform_gyrus_ComputeArea 4.969578e-01
## L_fusiform_gyrus_Volume 5.234830e-01
## R_fusiform_gyrus_ComputeArea 9.984871e-01
## R_fusiform_gyrus_Volume 9.270487e-01
## R_fusiform_gyrus_ShapeIndex 4.258413e-01
## R_fusiform_gyrus_Curvedness -3.039282e-03
## Sex -6.824889e-02
## Weight 8.851096e-03
## RG_ranked 7.965970e-03
## Age -6.594398e-02
## chr12_rs34637584_GT 8.552506e-03
## chr17_rs11868035_GT 4.123459e-02
## chr17_rs11012_GT -4.929622e-05
## chr17_rs393152_GT -3.003468e-03
## chr17_rs12185268_GT -9.276394e-04
## chr17_rs199533_GT -2.882744e-02
## UPDRS_Part_I_Summary_Score_Baseline -2.688771e-02
## UPDRS_Part_I_Summary_Score_Month_03 2.709070e-02
## UPDRS_Part_I_Summary_Score_Month_06 1.345387e-02
## UPDRS_Part_I_Summary_Score_Month_09 -3.879227e-03
## UPDRS_Part_I_Summary_Score_Month_12 -2.879869e-03
## UPDRS_Part_I_Summary_Score_Month_18 -2.943425e-03
## UPDRS_Part_I_Summary_Score_Month_24 -3.281665e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 1.161514e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 4.263336e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 3.134654e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 5.057020e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 3.852434e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 6.048502e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 5.751333e-02
## UPDRS_Part_III_Summary_Score_Baseline -5.766413e-03
## UPDRS_Part_III_Summary_Score_Month_03 8.383078e-03
## UPDRS_Part_III_Summary_Score_Month_06 1.267138e-02
## UPDRS_Part_III_Summary_Score_Month_09 -1.757489e-02
## UPDRS_Part_III_Summary_Score_Month_12 3.280198e-02
## UPDRS_Part_III_Summary_Score_Month_18 4.147457e-02
## UPDRS_Part_III_Summary_Score_Month_24 2.612264e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -7.843822e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -4.814929e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -5.734082e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -6.536832e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -1.021807e-01
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -5.190289e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 7.382102e-03
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 2.503513e-02
## ctrl -8.638400e-04
## pd 1.367456e-02
## swedd -2.114090e-02
## R_fusiform_gyrus_Volume
## L_insular_cortex_ComputeArea 0.5200102587
## L_insular_cortex_Volume 0.5075563810
## R_insular_cortex_ComputeArea 0.5483545358
## R_insular_cortex_Volume 0.5333147770
## L_cingulate_gyrus_ComputeArea 0.5213425252
## L_cingulate_gyrus_Volume 0.5144362408
## R_cingulate_gyrus_ComputeArea 0.5123236074
## R_cingulate_gyrus_Volume 0.5094896900
## L_caudate_ComputeArea 0.3914733440
## L_caudate_Volume 0.3689225159
## R_caudate_ComputeArea 0.4564789517
## R_caudate_Volume 0.4468740501
## L_putamen_ComputeArea 0.4144298744
## L_putamen_Volume 0.4112468907
## R_putamen_ComputeArea 0.4362005111
## R_putamen_Volume 0.4381047494
## L_hippocampus_ComputeArea 0.5493474592
## L_hippocampus_Volume 0.5478601354
## R_hippocampus_ComputeArea 0.6134905386
## R_hippocampus_Volume 0.6093837890
## cerebellum_ComputeArea 0.3410661569
## cerebellum_Volume 0.4889287663
## L_fusiform_gyrus_ComputeArea 0.4663368435
## L_fusiform_gyrus_Volume 0.6056916364
## R_fusiform_gyrus_ComputeArea 0.9270486523
## R_fusiform_gyrus_Volume 0.9984871407
## R_fusiform_gyrus_ShapeIndex 0.3302902502
## R_fusiform_gyrus_Curvedness -0.0029396958
## Sex -0.0824615473
## Weight 0.0348198071
## RG_ranked 0.0300016726
## Age -0.0907802510
## chr12_rs34637584_GT -0.0006378269
## chr17_rs11868035_GT 0.0764638191
## chr17_rs11012_GT 0.0009708872
## chr17_rs393152_GT 0.0042375999
## chr17_rs12185268_GT 0.0045634302
## chr17_rs199533_GT -0.0205877828
## UPDRS_Part_I_Summary_Score_Baseline -0.0124953968
## UPDRS_Part_I_Summary_Score_Month_03 0.0448273969
## UPDRS_Part_I_Summary_Score_Month_06 -0.0018963716
## UPDRS_Part_I_Summary_Score_Month_09 0.0070233139
## UPDRS_Part_I_Summary_Score_Month_12 0.0067685095
## UPDRS_Part_I_Summary_Score_Month_18 0.0073231411
## UPDRS_Part_I_Summary_Score_Month_24 -0.0293979388
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0365834504
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0521270405
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0452026431
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0595401760
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0553803090
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0748022732
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0810665753
## UPDRS_Part_III_Summary_Score_Baseline 0.0090916946
## UPDRS_Part_III_Summary_Score_Month_03 0.0060022386
## UPDRS_Part_III_Summary_Score_Month_06 0.0222691359
## UPDRS_Part_III_Summary_Score_Month_09 0.0010500215
## UPDRS_Part_III_Summary_Score_Month_12 0.0519501035
## UPDRS_Part_III_Summary_Score_Month_18 0.0557390211
## UPDRS_Part_III_Summary_Score_Month_24 0.0461270261
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0917120172
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0760829715
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0870566506
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0739891489
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0998149966
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0459830010
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0121931370
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0402510059
## ctrl -0.0207644604
## pd 0.0355092486
## swedd -0.0271457922
## R_fusiform_gyrus_ShapeIndex
## L_insular_cortex_ComputeArea 0.137684464
## L_insular_cortex_Volume 0.121778159
## R_insular_cortex_ComputeArea 0.167581672
## R_insular_cortex_Volume 0.153035676
## L_cingulate_gyrus_ComputeArea 0.156718909
## L_cingulate_gyrus_Volume 0.148376117
## R_cingulate_gyrus_ComputeArea 0.152634543
## R_cingulate_gyrus_Volume 0.150342672
## L_caudate_ComputeArea 0.120890290
## L_caudate_Volume 0.122623842
## R_caudate_ComputeArea 0.091490354
## R_caudate_Volume 0.106500672
## L_putamen_ComputeArea 0.122329115
## L_putamen_Volume 0.125614256
## R_putamen_ComputeArea 0.113064797
## R_putamen_Volume 0.102124337
## L_hippocampus_ComputeArea 0.158461561
## L_hippocampus_Volume 0.139701809
## R_hippocampus_ComputeArea 0.160487808
## R_hippocampus_Volume 0.135295522
## cerebellum_ComputeArea 0.257631457
## cerebellum_Volume 0.271571955
## L_fusiform_gyrus_ComputeArea 0.226627021
## L_fusiform_gyrus_Volume 0.211086190
## R_fusiform_gyrus_ComputeArea 0.425841280
## R_fusiform_gyrus_Volume 0.330290250
## R_fusiform_gyrus_ShapeIndex 0.998487141
## R_fusiform_gyrus_Curvedness -0.083605283
## Sex -0.023779643
## Weight -0.038523649
## RG_ranked 0.063881210
## Age 0.018583801
## chr12_rs34637584_GT 0.007745222
## chr17_rs11868035_GT 0.039155837
## chr17_rs11012_GT 0.013432116
## chr17_rs393152_GT -0.004903316
## chr17_rs12185268_GT 0.009137565
## chr17_rs199533_GT 0.001575285
## UPDRS_Part_I_Summary_Score_Baseline -0.015772024
## UPDRS_Part_I_Summary_Score_Month_03 0.007108913
## UPDRS_Part_I_Summary_Score_Month_06 -0.024226539
## UPDRS_Part_I_Summary_Score_Month_09 -0.039009880
## UPDRS_Part_I_Summary_Score_Month_12 -0.024722409
## UPDRS_Part_I_Summary_Score_Month_18 -0.008673743
## UPDRS_Part_I_Summary_Score_Month_24 -0.015838887
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.027635973
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.038482609
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.010234617
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.008029446
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.015190213
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.014486676
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.018453330
## UPDRS_Part_III_Summary_Score_Baseline 0.060835674
## UPDRS_Part_III_Summary_Score_Month_03 0.008963656
## UPDRS_Part_III_Summary_Score_Month_06 0.006298056
## UPDRS_Part_III_Summary_Score_Month_09 0.034727242
## UPDRS_Part_III_Summary_Score_Month_12 0.065052887
## UPDRS_Part_III_Summary_Score_Month_18 0.060734900
## UPDRS_Part_III_Summary_Score_Month_24 0.051232901
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.012523086
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.011742559
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.062710997
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.007846707
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.089054450
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.042888391
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.082733066
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.005082563
## ctrl -0.050747736
## pd 0.069640114
## swedd -0.038217033
## R_fusiform_gyrus_Curvedness
## L_insular_cortex_ComputeArea -0.0946166378
## L_insular_cortex_Volume -0.0887032980
## R_insular_cortex_ComputeArea -0.0911364037
## R_insular_cortex_Volume -0.0949546605
## L_cingulate_gyrus_ComputeArea -0.0989326104
## L_cingulate_gyrus_Volume -0.0962055605
## R_cingulate_gyrus_ComputeArea -0.0978312208
## R_cingulate_gyrus_Volume -0.0949057728
## L_caudate_ComputeArea -0.0953377593
## L_caudate_Volume -0.0865842135
## R_caudate_ComputeArea -0.0947483293
## R_caudate_Volume -0.0861128994
## L_putamen_ComputeArea -0.1047668378
## L_putamen_Volume -0.1047174226
## R_putamen_ComputeArea -0.1112102768
## R_putamen_Volume -0.1071264505
## L_hippocampus_ComputeArea -0.1079555023
## L_hippocampus_Volume -0.1035276149
## R_hippocampus_ComputeArea 0.0231700639
## R_hippocampus_Volume 0.0443408791
## cerebellum_ComputeArea -0.0694889270
## cerebellum_Volume -0.0766204554
## L_fusiform_gyrus_ComputeArea -0.0805789598
## L_fusiform_gyrus_Volume -0.1047270675
## R_fusiform_gyrus_ComputeArea -0.0030392823
## R_fusiform_gyrus_Volume -0.0029396958
## R_fusiform_gyrus_ShapeIndex -0.0836052828
## R_fusiform_gyrus_Curvedness 0.9984871407
## Sex -0.0392877633
## Weight 0.0149970835
## RG_ranked -0.0177949110
## Age 0.0464107560
## chr12_rs34637584_GT -0.0124504596
## chr17_rs11868035_GT 0.0820786841
## chr17_rs11012_GT -0.0023014742
## chr17_rs393152_GT -0.0163689210
## chr17_rs12185268_GT -0.0072075401
## chr17_rs199533_GT -0.0038802457
## UPDRS_Part_I_Summary_Score_Baseline 0.0525118472
## UPDRS_Part_I_Summary_Score_Month_03 0.0122108968
## UPDRS_Part_I_Summary_Score_Month_06 0.0704570427
## UPDRS_Part_I_Summary_Score_Month_09 0.0445133124
## UPDRS_Part_I_Summary_Score_Month_12 0.0628416262
## UPDRS_Part_I_Summary_Score_Month_18 0.0562145883
## UPDRS_Part_I_Summary_Score_Month_24 0.0726205977
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0604868986
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0857508661
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0317277872
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0281069403
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0491018735
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0408160646
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0760561226
## UPDRS_Part_III_Summary_Score_Baseline 0.0030156159
## UPDRS_Part_III_Summary_Score_Month_03 0.0292268380
## UPDRS_Part_III_Summary_Score_Month_06 0.0023625853
## UPDRS_Part_III_Summary_Score_Month_09 0.0516673459
## UPDRS_Part_III_Summary_Score_Month_12 0.0362855838
## UPDRS_Part_III_Summary_Score_Month_18 0.0121428851
## UPDRS_Part_III_Summary_Score_Month_24 0.0402313419
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.0006035692
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0421642319
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.0173985120
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0203688692
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.0111153191
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0930094637
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0175550371
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0234569967
## ctrl -0.0090856293
## pd -0.0406071078
## swedd 0.0802357934
## Sex
## L_insular_cortex_ComputeArea -0.0062038769
## L_insular_cortex_Volume -0.0053545194
## R_insular_cortex_ComputeArea 0.0100325262
## R_insular_cortex_Volume 0.0002925381
## L_cingulate_gyrus_ComputeArea 0.0129741126
## L_cingulate_gyrus_Volume -0.0090851439
## R_cingulate_gyrus_ComputeArea 0.0139881221
## R_cingulate_gyrus_Volume -0.0058817227
## L_caudate_ComputeArea 0.1105213563
## L_caudate_Volume 0.1120502613
## R_caudate_ComputeArea 0.0717577204
## R_caudate_Volume 0.0722024598
## L_putamen_ComputeArea 0.0688915458
## L_putamen_Volume 0.0509666039
## R_putamen_ComputeArea 0.0124099727
## R_putamen_Volume 0.0042711139
## L_hippocampus_ComputeArea -0.0575089764
## L_hippocampus_Volume -0.0731310695
## R_hippocampus_ComputeArea -0.0401117142
## R_hippocampus_Volume -0.0595385652
## cerebellum_ComputeArea -0.1065053962
## cerebellum_Volume -0.0641917379
## L_fusiform_gyrus_ComputeArea -0.1117174649
## L_fusiform_gyrus_Volume -0.1393547562
## R_fusiform_gyrus_ComputeArea -0.0682488932
## R_fusiform_gyrus_Volume -0.0824615473
## R_fusiform_gyrus_ShapeIndex -0.0237796425
## R_fusiform_gyrus_Curvedness -0.0392877633
## Sex 0.9984871407
## Weight -0.5143390515
## RG_ranked 0.0530742455
## Age -0.0764444183
## chr12_rs34637584_GT 0.0654279353
## chr17_rs11868035_GT 0.0092507150
## chr17_rs11012_GT -0.0157571539
## chr17_rs393152_GT -0.0257101568
## chr17_rs12185268_GT -0.0183253945
## chr17_rs199533_GT 0.0150348718
## UPDRS_Part_I_Summary_Score_Baseline 0.0922172019
## UPDRS_Part_I_Summary_Score_Month_03 0.0656645806
## UPDRS_Part_I_Summary_Score_Month_06 0.1381411195
## UPDRS_Part_I_Summary_Score_Month_09 0.0607552939
## UPDRS_Part_I_Summary_Score_Month_12 0.1196394104
## UPDRS_Part_I_Summary_Score_Month_18 0.1165645963
## UPDRS_Part_I_Summary_Score_Month_24 0.1051803374
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0009891118
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 -0.0459557893
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.0564912243
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0225095023
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.0138171258
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.0342851902
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -0.0655273000
## UPDRS_Part_III_Summary_Score_Baseline 0.0291687030
## UPDRS_Part_III_Summary_Score_Month_03 0.0269199691
## UPDRS_Part_III_Summary_Score_Month_06 0.0078918023
## UPDRS_Part_III_Summary_Score_Month_09 0.0115810019
## UPDRS_Part_III_Summary_Score_Month_12 0.0311215083
## UPDRS_Part_III_Summary_Score_Month_18 -0.0426707812
## UPDRS_Part_III_Summary_Score_Month_24 -0.0450894788
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0012506416
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0001388786
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0509710794
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0939649088
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0174602579
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0392878522
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0572343828
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0402640555
## ctrl -0.0569574191
## pd 0.0443472446
## swedd 0.0125841788
## Weight
## L_insular_cortex_ComputeArea -0.049917375
## L_insular_cortex_Volume -0.045290184
## R_insular_cortex_ComputeArea -0.050521141
## R_insular_cortex_Volume -0.042237323
## L_cingulate_gyrus_ComputeArea -0.030572296
## L_cingulate_gyrus_Volume -0.016089076
## R_cingulate_gyrus_ComputeArea -0.061658989
## R_cingulate_gyrus_Volume -0.048443353
## L_caudate_ComputeArea -0.086025750
## L_caudate_Volume -0.077483696
## R_caudate_ComputeArea -0.082088384
## R_caudate_Volume -0.074943149
## L_putamen_ComputeArea -0.102267664
## L_putamen_Volume -0.089561749
## R_putamen_ComputeArea -0.075057710
## R_putamen_Volume -0.072761609
## L_hippocampus_ComputeArea 0.007020847
## L_hippocampus_Volume 0.013030582
## R_hippocampus_ComputeArea -0.019794887
## R_hippocampus_Volume -0.007684473
## cerebellum_ComputeArea -0.032232146
## cerebellum_Volume -0.049349119
## L_fusiform_gyrus_ComputeArea 0.023579655
## L_fusiform_gyrus_Volume 0.041265392
## R_fusiform_gyrus_ComputeArea 0.008851096
## R_fusiform_gyrus_Volume 0.034819807
## R_fusiform_gyrus_ShapeIndex -0.038523649
## R_fusiform_gyrus_Curvedness 0.014997083
## Sex -0.514339051
## Weight 0.998487141
## RG_ranked -0.003203825
## Age -0.064355171
## chr12_rs34637584_GT -0.102756760
## chr17_rs11868035_GT -0.035169068
## chr17_rs11012_GT -0.065913600
## chr17_rs393152_GT -0.017695891
## chr17_rs12185268_GT -0.039529194
## chr17_rs199533_GT -0.051930685
## UPDRS_Part_I_Summary_Score_Baseline 0.037507477
## UPDRS_Part_I_Summary_Score_Month_03 0.040144165
## UPDRS_Part_I_Summary_Score_Month_06 -0.010291008
## UPDRS_Part_I_Summary_Score_Month_09 0.035513766
## UPDRS_Part_I_Summary_Score_Month_12 0.030533891
## UPDRS_Part_I_Summary_Score_Month_18 0.026711371
## UPDRS_Part_I_Summary_Score_Month_24 0.022709855
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.023700227
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.048314679
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.098489963
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.070316683
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.086360388
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.104130921
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.111724201
## UPDRS_Part_III_Summary_Score_Baseline 0.052555796
## UPDRS_Part_III_Summary_Score_Month_03 0.016660874
## UPDRS_Part_III_Summary_Score_Month_06 0.065514677
## UPDRS_Part_III_Summary_Score_Month_09 0.059713225
## UPDRS_Part_III_Summary_Score_Month_12 0.033419371
## UPDRS_Part_III_Summary_Score_Month_18 0.088261337
## UPDRS_Part_III_Summary_Score_Month_24 0.087959195
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.017868517
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.072475967
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.140115012
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.159401290
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.031037359
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.032194931
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.006894847
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.053837372
## ctrl -0.006013417
## pd -0.011308921
## swedd 0.027564299
## RG_ranked
## L_insular_cortex_ComputeArea 0.092257806
## L_insular_cortex_Volume 0.094892253
## R_insular_cortex_ComputeArea 0.123299569
## R_insular_cortex_Volume 0.126570035
## L_cingulate_gyrus_ComputeArea 0.103175533
## L_cingulate_gyrus_Volume 0.103076858
## R_cingulate_gyrus_ComputeArea 0.093177371
## R_cingulate_gyrus_Volume 0.096605772
## L_caudate_ComputeArea 0.090598359
## L_caudate_Volume 0.085492296
## R_caudate_ComputeArea 0.089762638
## R_caudate_Volume 0.084295481
## L_putamen_ComputeArea 0.124204874
## L_putamen_Volume 0.126572610
## R_putamen_ComputeArea 0.114034741
## R_putamen_Volume 0.108638682
## L_hippocampus_ComputeArea 0.086837960
## L_hippocampus_Volume 0.080774798
## R_hippocampus_ComputeArea 0.099125895
## R_hippocampus_Volume 0.092195685
## cerebellum_ComputeArea 0.032246004
## cerebellum_Volume 0.052182501
## L_fusiform_gyrus_ComputeArea 0.045066797
## L_fusiform_gyrus_Volume 0.080850825
## R_fusiform_gyrus_ComputeArea 0.007965970
## R_fusiform_gyrus_Volume 0.030001673
## R_fusiform_gyrus_ShapeIndex 0.063881210
## R_fusiform_gyrus_Curvedness -0.017794911
## Sex 0.053074245
## Weight -0.003203825
## RG_ranked 0.998487141
## Age 0.043511012
## chr12_rs34637584_GT 0.065901915
## chr17_rs11868035_GT -0.005623455
## chr17_rs11012_GT 0.011495928
## chr17_rs393152_GT -0.008736251
## chr17_rs12185268_GT 0.024085528
## chr17_rs199533_GT 0.048202989
## UPDRS_Part_I_Summary_Score_Baseline 0.154168533
## UPDRS_Part_I_Summary_Score_Month_03 0.050277025
## UPDRS_Part_I_Summary_Score_Month_06 0.030836685
## UPDRS_Part_I_Summary_Score_Month_09 -0.055499830
## UPDRS_Part_I_Summary_Score_Month_12 0.210834139
## UPDRS_Part_I_Summary_Score_Month_18 0.128059247
## UPDRS_Part_I_Summary_Score_Month_24 0.233841899
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.500772365
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.259699627
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.211944670
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.123410868
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.512559072
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.229821730
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.476069449
## UPDRS_Part_III_Summary_Score_Baseline 0.741031393
## UPDRS_Part_III_Summary_Score_Month_03 0.193355160
## UPDRS_Part_III_Summary_Score_Month_06 0.382273581
## UPDRS_Part_III_Summary_Score_Month_09 0.493300998
## UPDRS_Part_III_Summary_Score_Month_12 0.711822043
## UPDRS_Part_III_Summary_Score_Month_18 0.237350495
## UPDRS_Part_III_Summary_Score_Month_24 0.699758564
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.006306945
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.148288482
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.097291476
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.152434060
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.019963975
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.217620432
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.027083207
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.139801624
## ctrl -0.942578806
## pd 0.952083411
## swedd -0.149718200
## Age
## L_insular_cortex_ComputeArea -0.1602559767
## L_insular_cortex_Volume -0.1655513765
## R_insular_cortex_ComputeArea -0.1720166251
## R_insular_cortex_Volume -0.1897453455
## L_cingulate_gyrus_ComputeArea -0.1346152004
## L_cingulate_gyrus_Volume -0.1274193204
## R_cingulate_gyrus_ComputeArea -0.0932783633
## R_cingulate_gyrus_Volume -0.0753619528
## L_caudate_ComputeArea -0.3458374373
## L_caudate_Volume -0.3662007179
## R_caudate_ComputeArea -0.1831183363
## R_caudate_Volume -0.2010743679
## L_putamen_ComputeArea -0.1997314808
## L_putamen_Volume -0.2137946155
## R_putamen_ComputeArea -0.1147258088
## R_putamen_Volume -0.1217898599
## L_hippocampus_ComputeArea -0.1008856250
## L_hippocampus_Volume -0.1028432184
## R_hippocampus_ComputeArea -0.1167160249
## R_hippocampus_Volume -0.1115987183
## cerebellum_ComputeArea 0.0247048716
## cerebellum_Volume -0.0524653785
## L_fusiform_gyrus_ComputeArea -0.0441303678
## L_fusiform_gyrus_Volume -0.0904546024
## R_fusiform_gyrus_ComputeArea -0.0659439793
## R_fusiform_gyrus_Volume -0.0907802510
## R_fusiform_gyrus_ShapeIndex 0.0185838013
## R_fusiform_gyrus_Curvedness 0.0464107560
## Sex -0.0764444183
## Weight -0.0643551710
## RG_ranked 0.0435110123
## Age 0.9984871407
## chr12_rs34637584_GT -0.0013802191
## chr17_rs11868035_GT -0.0258747980
## chr17_rs11012_GT 0.0150040119
## chr17_rs393152_GT -0.0254769353
## chr17_rs12185268_GT 0.0307171189
## chr17_rs199533_GT 0.0034766984
## UPDRS_Part_I_Summary_Score_Baseline -0.0487880856
## UPDRS_Part_I_Summary_Score_Month_03 -0.0419189400
## UPDRS_Part_I_Summary_Score_Month_06 -0.0199010943
## UPDRS_Part_I_Summary_Score_Month_09 0.0278822401
## UPDRS_Part_I_Summary_Score_Month_12 0.0925460815
## UPDRS_Part_I_Summary_Score_Month_18 0.0247963355
## UPDRS_Part_I_Summary_Score_Month_24 0.0224025068
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0440121592
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0027694520
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.0221837964
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0333610263
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0607925208
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0249686486
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0761404722
## UPDRS_Part_III_Summary_Score_Baseline 0.1339692288
## UPDRS_Part_III_Summary_Score_Month_03 0.1048748743
## UPDRS_Part_III_Summary_Score_Month_06 0.0973635226
## UPDRS_Part_III_Summary_Score_Month_09 0.1599227666
## UPDRS_Part_III_Summary_Score_Month_12 0.1215588294
## UPDRS_Part_III_Summary_Score_Month_18 0.0748411801
## UPDRS_Part_III_Summary_Score_Month_24 0.1538051080
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.0003149907
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0259510618
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0034967507
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0403947106
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0633245524
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0479405435
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0260119249
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0190103623
## ctrl -0.0504915166
## pd 0.0328887890
## swedd 0.0216953025
## chr12_rs34637584_GT
## L_insular_cortex_ComputeArea 0.0230988958
## L_insular_cortex_Volume 0.0278308905
## R_insular_cortex_ComputeArea 0.0516330901
## R_insular_cortex_Volume 0.0453035050
## L_cingulate_gyrus_ComputeArea 0.0203057714
## L_cingulate_gyrus_Volume 0.0173659877
## R_cingulate_gyrus_ComputeArea 0.0358626107
## R_cingulate_gyrus_Volume 0.0274864084
## L_caudate_ComputeArea 0.0721703248
## L_caudate_Volume 0.0819444473
## R_caudate_ComputeArea 0.0553459118
## R_caudate_Volume 0.0552400523
## L_putamen_ComputeArea 0.0397629134
## L_putamen_Volume 0.0386518987
## R_putamen_ComputeArea 0.0419934714
## R_putamen_Volume 0.0406672855
## L_hippocampus_ComputeArea 0.0337480582
## L_hippocampus_Volume 0.0252712512
## R_hippocampus_ComputeArea 0.0342604710
## R_hippocampus_Volume 0.0237135971
## cerebellum_ComputeArea 0.0411081852
## cerebellum_Volume 0.0468097004
## L_fusiform_gyrus_ComputeArea 0.0510724715
## L_fusiform_gyrus_Volume 0.0471693026
## R_fusiform_gyrus_ComputeArea 0.0085525062
## R_fusiform_gyrus_Volume -0.0006378269
## R_fusiform_gyrus_ShapeIndex 0.0077452225
## R_fusiform_gyrus_Curvedness -0.0124504596
## Sex 0.0654279353
## Weight -0.1027567599
## RG_ranked 0.0659019154
## Age -0.0013802191
## chr12_rs34637584_GT 0.9984871407
## chr17_rs11868035_GT 0.0098503098
## chr17_rs11012_GT -0.0309560142
## chr17_rs393152_GT -0.0403149380
## chr17_rs12185268_GT -0.0378196334
## chr17_rs199533_GT -0.0366391639
## UPDRS_Part_I_Summary_Score_Baseline -0.0487679713
## UPDRS_Part_I_Summary_Score_Month_03 -0.0569922239
## UPDRS_Part_I_Summary_Score_Month_06 -0.0518704837
## UPDRS_Part_I_Summary_Score_Month_09 -0.0132002948
## UPDRS_Part_I_Summary_Score_Month_12 -0.0487210731
## UPDRS_Part_I_Summary_Score_Month_18 -0.0699542343
## UPDRS_Part_I_Summary_Score_Month_24 -0.0430569378
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0064242018
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 -0.0126008262
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.0458871719
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.0664003933
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.0016014611
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0061785525
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0029475133
## UPDRS_Part_III_Summary_Score_Baseline 0.0054086570
## UPDRS_Part_III_Summary_Score_Month_03 -0.1052839776
## UPDRS_Part_III_Summary_Score_Month_06 -0.0909843950
## UPDRS_Part_III_Summary_Score_Month_09 -0.0482542159
## UPDRS_Part_III_Summary_Score_Month_12 0.0232537871
## UPDRS_Part_III_Summary_Score_Month_18 0.0035214414
## UPDRS_Part_III_Summary_Score_Month_24 0.0153232568
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.0219272863
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0334411274
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0027999445
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.0222841377
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0375646423
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0475933204
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0283476006
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0277906325
## ctrl -0.0553412413
## pd 0.0691139183
## swedd -0.0304710026
## chr17_rs11868035_GT
## L_insular_cortex_ComputeArea 0.031755583
## L_insular_cortex_Volume 0.043814343
## R_insular_cortex_ComputeArea 0.038926949
## R_insular_cortex_Volume 0.049098124
## L_cingulate_gyrus_ComputeArea 0.051545416
## L_cingulate_gyrus_Volume 0.055981118
## R_cingulate_gyrus_ComputeArea 0.059395164
## R_cingulate_gyrus_Volume 0.062161342
## L_caudate_ComputeArea 0.056558668
## L_caudate_Volume 0.060021278
## R_caudate_ComputeArea 0.027328515
## R_caudate_Volume 0.034933876
## L_putamen_ComputeArea 0.061496487
## L_putamen_Volume 0.073689860
## R_putamen_ComputeArea 0.006186830
## R_putamen_Volume 0.014886742
## L_hippocampus_ComputeArea 0.024858655
## L_hippocampus_Volume 0.031736981
## R_hippocampus_ComputeArea 0.020180589
## R_hippocampus_Volume 0.024717722
## cerebellum_ComputeArea -0.031640992
## cerebellum_Volume 0.001698698
## L_fusiform_gyrus_ComputeArea -0.009039873
## L_fusiform_gyrus_Volume 0.019051633
## R_fusiform_gyrus_ComputeArea 0.041234590
## R_fusiform_gyrus_Volume 0.076463819
## R_fusiform_gyrus_ShapeIndex 0.039155837
## R_fusiform_gyrus_Curvedness 0.082078684
## Sex 0.009250715
## Weight -0.035169068
## RG_ranked -0.005623455
## Age -0.025874798
## chr12_rs34637584_GT 0.009850310
## chr17_rs11868035_GT 0.998487141
## chr17_rs11012_GT 0.043255348
## chr17_rs393152_GT 0.031478041
## chr17_rs12185268_GT 0.067640602
## chr17_rs199533_GT 0.018356794
## UPDRS_Part_I_Summary_Score_Baseline -0.068733656
## UPDRS_Part_I_Summary_Score_Month_03 -0.062780851
## UPDRS_Part_I_Summary_Score_Month_06 -0.038672684
## UPDRS_Part_I_Summary_Score_Month_09 -0.059153810
## UPDRS_Part_I_Summary_Score_Month_12 -0.063738461
## UPDRS_Part_I_Summary_Score_Month_18 -0.006201969
## UPDRS_Part_I_Summary_Score_Month_24 -0.047347624
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.001029768
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 -0.029828353
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.065488973
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.044642452
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.040918775
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.040297218
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -0.014497923
## UPDRS_Part_III_Summary_Score_Baseline -0.031584298
## UPDRS_Part_III_Summary_Score_Month_03 -0.052475711
## UPDRS_Part_III_Summary_Score_Month_06 -0.073367219
## UPDRS_Part_III_Summary_Score_Month_09 -0.033442908
## UPDRS_Part_III_Summary_Score_Month_12 -0.050309936
## UPDRS_Part_III_Summary_Score_Month_18 -0.042011928
## UPDRS_Part_III_Summary_Score_Month_24 -0.013551036
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.074780374
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.019251966
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.012825854
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.054786090
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.003394086
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.035572521
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.088072086
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.041446361
## ctrl -0.006226789
## pd -0.015897009
## swedd 0.035411476
## chr17_rs11012_GT
## L_insular_cortex_ComputeArea 2.018771e-02
## L_insular_cortex_Volume 1.922065e-02
## R_insular_cortex_ComputeArea 2.359867e-02
## R_insular_cortex_Volume 2.600273e-02
## L_cingulate_gyrus_ComputeArea 2.075218e-02
## L_cingulate_gyrus_Volume 2.717104e-02
## R_cingulate_gyrus_ComputeArea 3.168246e-02
## R_cingulate_gyrus_Volume 2.658995e-02
## L_caudate_ComputeArea 1.388321e-03
## L_caudate_Volume -4.447607e-03
## R_caudate_ComputeArea 1.449668e-02
## R_caudate_Volume 1.759636e-02
## L_putamen_ComputeArea 5.497153e-02
## L_putamen_Volume 5.086069e-02
## R_putamen_ComputeArea 2.875608e-03
## R_putamen_Volume 1.612494e-02
## L_hippocampus_ComputeArea 2.298300e-02
## L_hippocampus_Volume 2.670362e-02
## R_hippocampus_ComputeArea 1.583100e-02
## R_hippocampus_Volume 2.471590e-02
## cerebellum_ComputeArea -6.156917e-05
## cerebellum_Volume 7.792067e-03
## L_fusiform_gyrus_ComputeArea 8.415224e-03
## L_fusiform_gyrus_Volume 1.448029e-02
## R_fusiform_gyrus_ComputeArea -4.929622e-05
## R_fusiform_gyrus_Volume 9.708872e-04
## R_fusiform_gyrus_ShapeIndex 1.343212e-02
## R_fusiform_gyrus_Curvedness -2.301474e-03
## Sex -1.575715e-02
## Weight -6.591360e-02
## RG_ranked 1.149593e-02
## Age 1.500401e-02
## chr12_rs34637584_GT -3.095601e-02
## chr17_rs11868035_GT 4.325535e-02
## chr17_rs11012_GT 9.984871e-01
## chr17_rs393152_GT 7.963426e-01
## chr17_rs12185268_GT 8.788598e-01
## chr17_rs199533_GT 8.183772e-01
## UPDRS_Part_I_Summary_Score_Baseline 4.596965e-02
## UPDRS_Part_I_Summary_Score_Month_03 3.254666e-02
## UPDRS_Part_I_Summary_Score_Month_06 1.614160e-03
## UPDRS_Part_I_Summary_Score_Month_09 2.491460e-02
## UPDRS_Part_I_Summary_Score_Month_12 -1.644350e-03
## UPDRS_Part_I_Summary_Score_Month_18 -1.718953e-02
## UPDRS_Part_I_Summary_Score_Month_24 -5.981346e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 5.429568e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 4.831252e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 6.392521e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 3.945545e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 1.719963e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 1.780442e-02
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 5.600350e-03
## UPDRS_Part_III_Summary_Score_Baseline 2.896705e-02
## UPDRS_Part_III_Summary_Score_Month_03 3.755705e-02
## UPDRS_Part_III_Summary_Score_Month_06 -5.226512e-02
## UPDRS_Part_III_Summary_Score_Month_09 -7.551942e-03
## UPDRS_Part_III_Summary_Score_Month_12 1.513677e-02
## UPDRS_Part_III_Summary_Score_Month_18 8.641251e-04
## UPDRS_Part_III_Summary_Score_Month_24 1.718805e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -6.822503e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -4.856663e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -3.178823e-02
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -2.099316e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -2.749732e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -1.333687e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -1.596041e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -2.669988e-02
## ctrl -1.009891e-02
## pd 1.164965e-02
## swedd -3.981252e-03
## chr17_rs393152_GT
## L_insular_cortex_ComputeArea 0.0448283730
## L_insular_cortex_Volume 0.0416787020
## R_insular_cortex_ComputeArea 0.0432678163
## R_insular_cortex_Volume 0.0444662949
## L_cingulate_gyrus_ComputeArea 0.0389836994
## L_cingulate_gyrus_Volume 0.0391457883
## R_cingulate_gyrus_ComputeArea 0.0490504703
## R_cingulate_gyrus_Volume 0.0426402129
## L_caudate_ComputeArea 0.0061990347
## L_caudate_Volume 0.0021279731
## R_caudate_ComputeArea 0.0296114371
## R_caudate_Volume 0.0253232130
## L_putamen_ComputeArea 0.0562722469
## L_putamen_Volume 0.0535124121
## R_putamen_ComputeArea 0.0183134725
## R_putamen_Volume 0.0273993404
## L_hippocampus_ComputeArea 0.0360770408
## L_hippocampus_Volume 0.0360348807
## R_hippocampus_ComputeArea 0.0340208828
## R_hippocampus_Volume 0.0375440776
## cerebellum_ComputeArea 0.0056851167
## cerebellum_Volume 0.0124076314
## L_fusiform_gyrus_ComputeArea -0.0016871224
## L_fusiform_gyrus_Volume 0.0139521159
## R_fusiform_gyrus_ComputeArea -0.0030034684
## R_fusiform_gyrus_Volume 0.0042375999
## R_fusiform_gyrus_ShapeIndex -0.0049033165
## R_fusiform_gyrus_Curvedness -0.0163689210
## Sex -0.0257101568
## Weight -0.0176958913
## RG_ranked -0.0087362511
## Age -0.0254769353
## chr12_rs34637584_GT -0.0403149380
## chr17_rs11868035_GT 0.0314780409
## chr17_rs11012_GT 0.7963426376
## chr17_rs393152_GT 0.9984871407
## chr17_rs12185268_GT 0.9150928244
## chr17_rs199533_GT 0.8475579050
## UPDRS_Part_I_Summary_Score_Baseline 0.0563758501
## UPDRS_Part_I_Summary_Score_Month_03 0.0874761757
## UPDRS_Part_I_Summary_Score_Month_06 0.0315209788
## UPDRS_Part_I_Summary_Score_Month_09 0.0994880764
## UPDRS_Part_I_Summary_Score_Month_12 0.0334271751
## UPDRS_Part_I_Summary_Score_Month_18 0.0522695918
## UPDRS_Part_I_Summary_Score_Month_24 -0.0075027986
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0938918008
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.1222679088
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1291734825
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.1029933448
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0574134489
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0851065675
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0691092510
## UPDRS_Part_III_Summary_Score_Baseline 0.0344483361
## UPDRS_Part_III_Summary_Score_Month_03 0.0597810941
## UPDRS_Part_III_Summary_Score_Month_06 -0.0313373702
## UPDRS_Part_III_Summary_Score_Month_09 -0.0235308670
## UPDRS_Part_III_Summary_Score_Month_12 -0.0023375459
## UPDRS_Part_III_Summary_Score_Month_18 0.0555292664
## UPDRS_Part_III_Summary_Score_Month_24 0.0094589497
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0450143748
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0122020373
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.0027543018
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.0156472470
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.0142623998
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0299255058
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0457259183
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0116394990
## ctrl 0.0177704293
## pd 0.0003671384
## swedd -0.0272288437
## chr17_rs12185268_GT
## L_insular_cortex_ComputeArea 0.0418310285
## L_insular_cortex_Volume 0.0442113740
## R_insular_cortex_ComputeArea 0.0387209093
## R_insular_cortex_Volume 0.0428400578
## L_cingulate_gyrus_ComputeArea 0.0389202711
## L_cingulate_gyrus_Volume 0.0405439434
## R_cingulate_gyrus_ComputeArea 0.0499045531
## R_cingulate_gyrus_Volume 0.0433789454
## L_caudate_ComputeArea 0.0093812824
## L_caudate_Volume 0.0078619797
## R_caudate_ComputeArea 0.0355599782
## R_caudate_Volume 0.0359435028
## L_putamen_ComputeArea 0.0729178882
## L_putamen_Volume 0.0654701835
## R_putamen_ComputeArea 0.0231816297
## R_putamen_Volume 0.0335374826
## L_hippocampus_ComputeArea 0.0166489178
## L_hippocampus_Volume 0.0236528132
## R_hippocampus_ComputeArea 0.0153772158
## R_hippocampus_Volume 0.0250848287
## cerebellum_ComputeArea 0.0030326878
## cerebellum_Volume 0.0062140284
## L_fusiform_gyrus_ComputeArea 0.0040783463
## L_fusiform_gyrus_Volume 0.0183979392
## R_fusiform_gyrus_ComputeArea -0.0009276394
## R_fusiform_gyrus_Volume 0.0045634302
## R_fusiform_gyrus_ShapeIndex 0.0091375648
## R_fusiform_gyrus_Curvedness -0.0072075401
## Sex -0.0183253945
## Weight -0.0395291938
## RG_ranked 0.0240855277
## Age 0.0307171189
## chr12_rs34637584_GT -0.0378196334
## chr17_rs11868035_GT 0.0676406018
## chr17_rs11012_GT 0.8788597808
## chr17_rs393152_GT 0.9150928244
## chr17_rs12185268_GT 0.9984871407
## chr17_rs199533_GT 0.9232511659
## UPDRS_Part_I_Summary_Score_Baseline 0.0631955097
## UPDRS_Part_I_Summary_Score_Month_03 0.0648876585
## UPDRS_Part_I_Summary_Score_Month_06 0.0034423615
## UPDRS_Part_I_Summary_Score_Month_09 0.0746747126
## UPDRS_Part_I_Summary_Score_Month_12 0.0367089781
## UPDRS_Part_I_Summary_Score_Month_18 0.0317815986
## UPDRS_Part_I_Summary_Score_Month_24 -0.0298454625
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.1090552731
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0990285284
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1323746077
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0942330714
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0777607473
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0775788698
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0686021770
## UPDRS_Part_III_Summary_Score_Baseline 0.0639892726
## UPDRS_Part_III_Summary_Score_Month_03 0.0691391521
## UPDRS_Part_III_Summary_Score_Month_06 -0.0269438063
## UPDRS_Part_III_Summary_Score_Month_09 0.0111927922
## UPDRS_Part_III_Summary_Score_Month_12 0.0339984816
## UPDRS_Part_III_Summary_Score_Month_18 0.0474331172
## UPDRS_Part_III_Summary_Score_Month_24 0.0331911885
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0360165959
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0069022072
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.0063070062
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.0375412262
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0113591204
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0033427122
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0176402045
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.0117262532
## ctrl -0.0191212864
## pd 0.0262682101
## swedd -0.0144465025
## chr17_rs199533_GT
## L_insular_cortex_ComputeArea 0.0236738388
## L_insular_cortex_Volume 0.0200088115
## R_insular_cortex_ComputeArea 0.0342155068
## R_insular_cortex_Volume 0.0346255584
## L_cingulate_gyrus_ComputeArea 0.0262377312
## L_cingulate_gyrus_Volume 0.0242222818
## R_cingulate_gyrus_ComputeArea 0.0292503482
## R_cingulate_gyrus_Volume 0.0207582473
## L_caudate_ComputeArea 0.0080807771
## L_caudate_Volume 0.0033640797
## R_caudate_ComputeArea 0.0246171450
## R_caudate_Volume 0.0209737717
## L_putamen_ComputeArea 0.0521373857
## L_putamen_Volume 0.0382366189
## R_putamen_ComputeArea 0.0159948865
## R_putamen_Volume 0.0241329814
## L_hippocampus_ComputeArea 0.0111770978
## L_hippocampus_Volume 0.0153213940
## R_hippocampus_ComputeArea 0.0217591851
## R_hippocampus_Volume 0.0286894750
## cerebellum_ComputeArea -0.0115494108
## cerebellum_Volume 0.0005910261
## L_fusiform_gyrus_ComputeArea 0.0053835459
## L_fusiform_gyrus_Volume 0.0185341903
## R_fusiform_gyrus_ComputeArea -0.0288274402
## R_fusiform_gyrus_Volume -0.0205877828
## R_fusiform_gyrus_ShapeIndex 0.0015752846
## R_fusiform_gyrus_Curvedness -0.0038802457
## Sex 0.0150348718
## Weight -0.0519306849
## RG_ranked 0.0482029889
## Age 0.0034766984
## chr12_rs34637584_GT -0.0366391639
## chr17_rs11868035_GT 0.0183567938
## chr17_rs11012_GT 0.8183772266
## chr17_rs393152_GT 0.8475579050
## chr17_rs12185268_GT 0.9232511659
## chr17_rs199533_GT 0.9984871407
## UPDRS_Part_I_Summary_Score_Baseline 0.0755942131
## UPDRS_Part_I_Summary_Score_Month_03 0.0634309927
## UPDRS_Part_I_Summary_Score_Month_06 -0.0023008312
## UPDRS_Part_I_Summary_Score_Month_09 0.0740204829
## UPDRS_Part_I_Summary_Score_Month_12 0.0363425927
## UPDRS_Part_I_Summary_Score_Month_18 0.0303697785
## UPDRS_Part_I_Summary_Score_Month_24 -0.0161769189
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.1101159787
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0937285064
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1176181628
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0726400999
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.0812098317
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0732638910
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.0735657096
## UPDRS_Part_III_Summary_Score_Baseline 0.0932402841
## UPDRS_Part_III_Summary_Score_Month_03 0.0721674056
## UPDRS_Part_III_Summary_Score_Month_06 -0.0120347057
## UPDRS_Part_III_Summary_Score_Month_09 0.0049876355
## UPDRS_Part_III_Summary_Score_Month_12 0.0587758866
## UPDRS_Part_III_Summary_Score_Month_18 0.0667079770
## UPDRS_Part_III_Summary_Score_Month_24 0.0556534639
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0309864247
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.0083136645
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.0080095304
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.0550297207
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0308083854
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.0012224539
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.0144809797
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0140394982
## ctrl -0.0453539066
## pd 0.0460998376
## swedd -0.0076774577
## UPDRS_Part_I_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.0093744151
## L_insular_cortex_Volume -0.0156849375
## R_insular_cortex_ComputeArea 0.0021335357
## R_insular_cortex_Volume -0.0181953313
## L_cingulate_gyrus_ComputeArea 0.0181933492
## L_cingulate_gyrus_Volume -0.0002514912
## R_cingulate_gyrus_ComputeArea 0.0102128998
## R_cingulate_gyrus_Volume -0.0021387971
## L_caudate_ComputeArea -0.0087591469
## L_caudate_Volume -0.0188219097
## R_caudate_ComputeArea 0.0291892638
## R_caudate_Volume 0.0215234380
## L_putamen_ComputeArea -0.0104363723
## L_putamen_Volume -0.0135216737
## R_putamen_ComputeArea 0.0236048749
## R_putamen_Volume 0.0179815379
## L_hippocampus_ComputeArea 0.0025619304
## L_hippocampus_Volume -0.0129043722
## R_hippocampus_ComputeArea 0.0073306444
## R_hippocampus_Volume -0.0001511590
## cerebellum_ComputeArea -0.0380576005
## cerebellum_Volume -0.0345374250
## L_fusiform_gyrus_ComputeArea 0.0086240919
## L_fusiform_gyrus_Volume 0.0144854955
## R_fusiform_gyrus_ComputeArea -0.0268877127
## R_fusiform_gyrus_Volume -0.0124953968
## R_fusiform_gyrus_ShapeIndex -0.0157720243
## R_fusiform_gyrus_Curvedness 0.0525118472
## Sex 0.0922172019
## Weight 0.0375074772
## RG_ranked 0.1541685326
## Age -0.0487880856
## chr12_rs34637584_GT -0.0487679713
## chr17_rs11868035_GT -0.0687336563
## chr17_rs11012_GT 0.0459696544
## chr17_rs393152_GT 0.0563758501
## chr17_rs12185268_GT 0.0631955097
## chr17_rs199533_GT 0.0755942131
## UPDRS_Part_I_Summary_Score_Baseline 0.9984871407
## UPDRS_Part_I_Summary_Score_Month_03 0.5342472809
## UPDRS_Part_I_Summary_Score_Month_06 0.5734978388
## UPDRS_Part_I_Summary_Score_Month_09 0.5364759772
## UPDRS_Part_I_Summary_Score_Month_12 0.6104910821
## UPDRS_Part_I_Summary_Score_Month_18 0.5332010253
## UPDRS_Part_I_Summary_Score_Month_24 0.5717997509
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.3933074282
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.3874423426
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.3970107393
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.2758413577
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.3858117892
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.3255911663
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.3430046311
## UPDRS_Part_III_Summary_Score_Baseline 0.2785937476
## UPDRS_Part_III_Summary_Score_Month_03 0.1166076547
## UPDRS_Part_III_Summary_Score_Month_06 0.2340186113
## UPDRS_Part_III_Summary_Score_Month_09 0.1809313429
## UPDRS_Part_III_Summary_Score_Month_12 0.2949945096
## UPDRS_Part_III_Summary_Score_Month_18 0.1062937705
## UPDRS_Part_III_Summary_Score_Month_24 0.2124565996
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.2302962180
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.1782895521
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.2061185034
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.2168203872
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.1978582598
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.3016609052
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.2529780215
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.2244256796
## ctrl -0.2515384383
## pd 0.0501950802
## swedd 0.2945422676
## UPDRS_Part_I_Summary_Score_Month_03
## L_insular_cortex_ComputeArea -0.0124532300
## L_insular_cortex_Volume -0.0103218109
## R_insular_cortex_ComputeArea 0.0099916445
## R_insular_cortex_Volume 0.0059169592
## L_cingulate_gyrus_ComputeArea 0.0158530600
## L_cingulate_gyrus_Volume 0.0114968046
## R_cingulate_gyrus_ComputeArea -0.0018535451
## R_cingulate_gyrus_Volume -0.0077044098
## L_caudate_ComputeArea 0.0194802432
## L_caudate_Volume 0.0230314252
## R_caudate_ComputeArea 0.0234636525
## R_caudate_Volume 0.0292734742
## L_putamen_ComputeArea -0.0135941528
## L_putamen_Volume -0.0179386610
## R_putamen_ComputeArea 0.0121349572
## R_putamen_Volume 0.0029298532
## L_hippocampus_ComputeArea 0.0138211058
## L_hippocampus_Volume 0.0026473285
## R_hippocampus_ComputeArea 0.0039113274
## R_hippocampus_Volume -0.0003478357
## cerebellum_ComputeArea -0.0310874396
## cerebellum_Volume -0.0168181728
## L_fusiform_gyrus_ComputeArea -0.0473568286
## L_fusiform_gyrus_Volume -0.0347247027
## R_fusiform_gyrus_ComputeArea 0.0270906987
## R_fusiform_gyrus_Volume 0.0448273969
## R_fusiform_gyrus_ShapeIndex 0.0071089131
## R_fusiform_gyrus_Curvedness 0.0122108968
## Sex 0.0656645806
## Weight 0.0401441655
## RG_ranked 0.0502770246
## Age -0.0419189400
## chr12_rs34637584_GT -0.0569922239
## chr17_rs11868035_GT -0.0627808509
## chr17_rs11012_GT 0.0325466644
## chr17_rs393152_GT 0.0874761757
## chr17_rs12185268_GT 0.0648876585
## chr17_rs199533_GT 0.0634309927
## UPDRS_Part_I_Summary_Score_Baseline 0.5342472809
## UPDRS_Part_I_Summary_Score_Month_03 0.9984871407
## UPDRS_Part_I_Summary_Score_Month_06 0.5035363334
## UPDRS_Part_I_Summary_Score_Month_09 0.4240092337
## UPDRS_Part_I_Summary_Score_Month_12 0.4662990015
## UPDRS_Part_I_Summary_Score_Month_18 0.5258858548
## UPDRS_Part_I_Summary_Score_Month_24 0.5136553948
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.2668823808
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.3761767182
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.3214546598
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.2593369788
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.2798454272
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.2707783812
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.2963114729
## UPDRS_Part_III_Summary_Score_Baseline 0.1733424103
## UPDRS_Part_III_Summary_Score_Month_03 0.1713107643
## UPDRS_Part_III_Summary_Score_Month_06 0.2102095727
## UPDRS_Part_III_Summary_Score_Month_09 0.1412452470
## UPDRS_Part_III_Summary_Score_Month_12 0.2189966898
## UPDRS_Part_III_Summary_Score_Month_18 0.1765775809
## UPDRS_Part_III_Summary_Score_Month_24 0.1720992042
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.1129874473
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.1855210392
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.2261823098
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.2186880219
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.1282732039
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.1874855093
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.1638078847
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.2365836928
## ctrl -0.0875494930
## pd 0.0113296453
## swedd 0.1125925986
## UPDRS_Part_I_Summary_Score_Month_06
## L_insular_cortex_ComputeArea -0.079167932
## L_insular_cortex_Volume -0.076403986
## R_insular_cortex_ComputeArea -0.062858873
## R_insular_cortex_Volume -0.067598272
## L_cingulate_gyrus_ComputeArea -0.042073149
## L_cingulate_gyrus_Volume -0.057684484
## R_cingulate_gyrus_ComputeArea -0.046074297
## R_cingulate_gyrus_Volume -0.053542568
## L_caudate_ComputeArea -0.042463722
## L_caudate_Volume -0.044948510
## R_caudate_ComputeArea -0.035800189
## R_caudate_Volume -0.039251205
## L_putamen_ComputeArea -0.062346965
## L_putamen_Volume -0.055049516
## R_putamen_ComputeArea -0.056290667
## R_putamen_Volume -0.055825859
## L_hippocampus_ComputeArea -0.078420143
## L_hippocampus_Volume -0.084948626
## R_hippocampus_ComputeArea -0.035395949
## R_hippocampus_Volume -0.042458396
## cerebellum_ComputeArea -0.067714939
## cerebellum_Volume -0.075875028
## L_fusiform_gyrus_ComputeArea -0.028391048
## L_fusiform_gyrus_Volume -0.053640176
## R_fusiform_gyrus_ComputeArea 0.013453874
## R_fusiform_gyrus_Volume -0.001896372
## R_fusiform_gyrus_ShapeIndex -0.024226539
## R_fusiform_gyrus_Curvedness 0.070457043
## Sex 0.138141120
## Weight -0.010291008
## RG_ranked 0.030836685
## Age -0.019901094
## chr12_rs34637584_GT -0.051870484
## chr17_rs11868035_GT -0.038672684
## chr17_rs11012_GT 0.001614160
## chr17_rs393152_GT 0.031520979
## chr17_rs12185268_GT 0.003442361
## chr17_rs199533_GT -0.002300831
## UPDRS_Part_I_Summary_Score_Baseline 0.573497839
## UPDRS_Part_I_Summary_Score_Month_03 0.503536333
## UPDRS_Part_I_Summary_Score_Month_06 0.998487141
## UPDRS_Part_I_Summary_Score_Month_09 0.639807270
## UPDRS_Part_I_Summary_Score_Month_12 0.650209154
## UPDRS_Part_I_Summary_Score_Month_18 0.576032766
## UPDRS_Part_I_Summary_Score_Month_24 0.560832838
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.228740726
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.240410732
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.309436987
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.288889330
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.282586253
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.245980687
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.243501444
## UPDRS_Part_III_Summary_Score_Baseline 0.118509178
## UPDRS_Part_III_Summary_Score_Month_03 0.095257627
## UPDRS_Part_III_Summary_Score_Month_06 0.248676251
## UPDRS_Part_III_Summary_Score_Month_09 0.115131797
## UPDRS_Part_III_Summary_Score_Month_12 0.193635161
## UPDRS_Part_III_Summary_Score_Month_18 0.107533541
## UPDRS_Part_III_Summary_Score_Month_24 0.105860002
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.088204859
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.133492675
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.212931428
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.117935688
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.160051808
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.336818474
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.309374418
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.271543989
## ctrl -0.075991313
## pd -0.013411642
## swedd 0.135866202
## UPDRS_Part_I_Summary_Score_Month_09
## L_insular_cortex_ComputeArea -0.054935336
## L_insular_cortex_Volume -0.055750417
## R_insular_cortex_ComputeArea -0.053175869
## R_insular_cortex_Volume -0.063163655
## L_cingulate_gyrus_ComputeArea -0.036207694
## L_cingulate_gyrus_Volume -0.048521239
## R_cingulate_gyrus_ComputeArea -0.046139491
## R_cingulate_gyrus_Volume -0.050707536
## L_caudate_ComputeArea -0.091685851
## L_caudate_Volume -0.097427267
## R_caudate_ComputeArea -0.026662014
## R_caudate_Volume -0.031031196
## L_putamen_ComputeArea -0.090418026
## L_putamen_Volume -0.088272810
## R_putamen_ComputeArea -0.043788660
## R_putamen_Volume -0.039584626
## L_hippocampus_ComputeArea -0.065198729
## L_hippocampus_Volume -0.066474377
## R_hippocampus_ComputeArea -0.004018629
## R_hippocampus_Volume -0.008647574
## cerebellum_ComputeArea -0.070995019
## cerebellum_Volume -0.087997084
## L_fusiform_gyrus_ComputeArea -0.078450200
## L_fusiform_gyrus_Volume -0.078885266
## R_fusiform_gyrus_ComputeArea -0.003879227
## R_fusiform_gyrus_Volume 0.007023314
## R_fusiform_gyrus_ShapeIndex -0.039009880
## R_fusiform_gyrus_Curvedness 0.044513312
## Sex 0.060755294
## Weight 0.035513766
## RG_ranked -0.055499830
## Age 0.027882240
## chr12_rs34637584_GT -0.013200295
## chr17_rs11868035_GT -0.059153810
## chr17_rs11012_GT 0.024914601
## chr17_rs393152_GT 0.099488076
## chr17_rs12185268_GT 0.074674713
## chr17_rs199533_GT 0.074020483
## UPDRS_Part_I_Summary_Score_Baseline 0.536475977
## UPDRS_Part_I_Summary_Score_Month_03 0.424009234
## UPDRS_Part_I_Summary_Score_Month_06 0.639807270
## UPDRS_Part_I_Summary_Score_Month_09 0.998487141
## UPDRS_Part_I_Summary_Score_Month_12 0.729145755
## UPDRS_Part_I_Summary_Score_Month_18 0.663304153
## UPDRS_Part_I_Summary_Score_Month_24 0.580590578
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.257036799
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.286590419
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.364317921
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.442248980
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.327515420
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.387934028
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.321986433
## UPDRS_Part_III_Summary_Score_Baseline 0.084806786
## UPDRS_Part_III_Summary_Score_Month_03 0.174013118
## UPDRS_Part_III_Summary_Score_Month_06 0.206532578
## UPDRS_Part_III_Summary_Score_Month_09 0.186928599
## UPDRS_Part_III_Summary_Score_Month_12 0.176119388
## UPDRS_Part_III_Summary_Score_Month_18 0.202812875
## UPDRS_Part_III_Summary_Score_Month_24 0.097490049
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.190721456
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.218595666
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.213160139
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.198240875
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.132673407
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.237013696
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.215282054
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.266036309
## ctrl 0.003094521
## pd -0.097942609
## swedd 0.156053320
## UPDRS_Part_I_Summary_Score_Month_12
## L_insular_cortex_ComputeArea -0.059589111
## L_insular_cortex_Volume -0.056604522
## R_insular_cortex_ComputeArea -0.054400831
## R_insular_cortex_Volume -0.062339614
## L_cingulate_gyrus_ComputeArea -0.034674791
## L_cingulate_gyrus_Volume -0.048319933
## R_cingulate_gyrus_ComputeArea -0.046291661
## R_cingulate_gyrus_Volume -0.053594257
## L_caudate_ComputeArea -0.071505526
## L_caudate_Volume -0.075180771
## R_caudate_ComputeArea -0.022933628
## R_caudate_Volume -0.023764639
## L_putamen_ComputeArea -0.063699894
## L_putamen_Volume -0.062243345
## R_putamen_ComputeArea -0.032318973
## R_putamen_Volume -0.030155907
## L_hippocampus_ComputeArea -0.043498423
## L_hippocampus_Volume -0.049947198
## R_hippocampus_ComputeArea -0.003216987
## R_hippocampus_Volume -0.010970736
## cerebellum_ComputeArea -0.023426744
## cerebellum_Volume -0.054263081
## L_fusiform_gyrus_ComputeArea -0.011787737
## L_fusiform_gyrus_Volume -0.017400857
## R_fusiform_gyrus_ComputeArea -0.002879869
## R_fusiform_gyrus_Volume 0.006768509
## R_fusiform_gyrus_ShapeIndex -0.024722409
## R_fusiform_gyrus_Curvedness 0.062841626
## Sex 0.119639410
## Weight 0.030533891
## RG_ranked 0.210834139
## Age 0.092546081
## chr12_rs34637584_GT -0.048721073
## chr17_rs11868035_GT -0.063738461
## chr17_rs11012_GT -0.001644350
## chr17_rs393152_GT 0.033427175
## chr17_rs12185268_GT 0.036708978
## chr17_rs199533_GT 0.036342593
## UPDRS_Part_I_Summary_Score_Baseline 0.610491082
## UPDRS_Part_I_Summary_Score_Month_03 0.466299002
## UPDRS_Part_I_Summary_Score_Month_06 0.650209154
## UPDRS_Part_I_Summary_Score_Month_09 0.729145755
## UPDRS_Part_I_Summary_Score_Month_12 0.998487141
## UPDRS_Part_I_Summary_Score_Month_18 0.709341596
## UPDRS_Part_I_Summary_Score_Month_24 0.678230973
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.428079664
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.348752845
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.419888021
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.403036040
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.520453804
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.445504987
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.457804627
## UPDRS_Part_III_Summary_Score_Baseline 0.284098822
## UPDRS_Part_III_Summary_Score_Month_03 0.142407403
## UPDRS_Part_III_Summary_Score_Month_06 0.285384441
## UPDRS_Part_III_Summary_Score_Month_09 0.233812475
## UPDRS_Part_III_Summary_Score_Month_12 0.380366068
## UPDRS_Part_III_Summary_Score_Month_18 0.188168774
## UPDRS_Part_III_Summary_Score_Month_24 0.301704354
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.221476427
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.238560183
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.267898694
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.247800781
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.115914668
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.319867776
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.284387093
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.283025264
## ctrl -0.298074345
## pd 0.110580657
## swedd 0.265197902
## UPDRS_Part_I_Summary_Score_Month_18
## L_insular_cortex_ComputeArea -0.048619887
## L_insular_cortex_Volume -0.045266568
## R_insular_cortex_ComputeArea -0.046581375
## R_insular_cortex_Volume -0.057083676
## L_cingulate_gyrus_ComputeArea -0.023394696
## L_cingulate_gyrus_Volume -0.037957119
## R_cingulate_gyrus_ComputeArea -0.043036780
## R_cingulate_gyrus_Volume -0.050101163
## L_caudate_ComputeArea -0.051010557
## L_caudate_Volume -0.051921431
## R_caudate_ComputeArea -0.021415018
## R_caudate_Volume -0.015408443
## L_putamen_ComputeArea -0.063883654
## L_putamen_Volume -0.061305591
## R_putamen_ComputeArea -0.026289168
## R_putamen_Volume -0.023632424
## L_hippocampus_ComputeArea -0.042537386
## L_hippocampus_Volume -0.045142073
## R_hippocampus_ComputeArea -0.037814827
## R_hippocampus_Volume -0.037350403
## cerebellum_ComputeArea -0.023471883
## cerebellum_Volume -0.038492473
## L_fusiform_gyrus_ComputeArea -0.012909045
## L_fusiform_gyrus_Volume -0.019615071
## R_fusiform_gyrus_ComputeArea -0.002943425
## R_fusiform_gyrus_Volume 0.007323141
## R_fusiform_gyrus_ShapeIndex -0.008673743
## R_fusiform_gyrus_Curvedness 0.056214588
## Sex 0.116564596
## Weight 0.026711371
## RG_ranked 0.128059247
## Age 0.024796336
## chr12_rs34637584_GT -0.069954234
## chr17_rs11868035_GT -0.006201969
## chr17_rs11012_GT -0.017189528
## chr17_rs393152_GT 0.052269592
## chr17_rs12185268_GT 0.031781599
## chr17_rs199533_GT 0.030369779
## UPDRS_Part_I_Summary_Score_Baseline 0.533201025
## UPDRS_Part_I_Summary_Score_Month_03 0.525885855
## UPDRS_Part_I_Summary_Score_Month_06 0.576032766
## UPDRS_Part_I_Summary_Score_Month_09 0.663304153
## UPDRS_Part_I_Summary_Score_Month_12 0.709341596
## UPDRS_Part_I_Summary_Score_Month_18 0.998487141
## UPDRS_Part_I_Summary_Score_Month_24 0.709959714
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.386415495
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.347666519
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.309382510
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.374044025
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.391341443
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.440672783
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.403546398
## UPDRS_Part_III_Summary_Score_Baseline 0.300345700
## UPDRS_Part_III_Summary_Score_Month_03 0.294425062
## UPDRS_Part_III_Summary_Score_Month_06 0.317430520
## UPDRS_Part_III_Summary_Score_Month_09 0.289925384
## UPDRS_Part_III_Summary_Score_Month_12 0.317332492
## UPDRS_Part_III_Summary_Score_Month_18 0.317468193
## UPDRS_Part_III_Summary_Score_Month_24 0.302680410
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.201162970
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.216340370
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.288145482
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.242071960
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.133769381
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.341320814
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.232313369
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.277253935
## ctrl -0.177651634
## pd 0.070268082
## swedd 0.150900384
## UPDRS_Part_I_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.051307730
## L_insular_cortex_Volume -0.052011221
## R_insular_cortex_ComputeArea -0.042677210
## R_insular_cortex_Volume -0.056303508
## L_cingulate_gyrus_ComputeArea -0.018508038
## L_cingulate_gyrus_Volume -0.037304139
## R_cingulate_gyrus_ComputeArea -0.028309355
## R_cingulate_gyrus_Volume -0.038202657
## L_caudate_ComputeArea -0.074295474
## L_caudate_Volume -0.073109081
## R_caudate_ComputeArea -0.023033479
## R_caudate_Volume -0.023186978
## L_putamen_ComputeArea -0.047324918
## L_putamen_Volume -0.044200184
## R_putamen_ComputeArea -0.012942248
## R_putamen_Volume -0.018134402
## L_hippocampus_ComputeArea -0.041064037
## L_hippocampus_Volume -0.055002700
## R_hippocampus_ComputeArea -0.042316886
## R_hippocampus_Volume -0.042932736
## cerebellum_ComputeArea -0.042697035
## cerebellum_Volume -0.072931500
## L_fusiform_gyrus_ComputeArea -0.018129135
## L_fusiform_gyrus_Volume -0.029313654
## R_fusiform_gyrus_ComputeArea -0.032816649
## R_fusiform_gyrus_Volume -0.029397939
## R_fusiform_gyrus_ShapeIndex -0.015838887
## R_fusiform_gyrus_Curvedness 0.072620598
## Sex 0.105180337
## Weight 0.022709855
## RG_ranked 0.233841899
## Age 0.022402507
## chr12_rs34637584_GT -0.043056938
## chr17_rs11868035_GT -0.047347624
## chr17_rs11012_GT -0.059813463
## chr17_rs393152_GT -0.007502799
## chr17_rs12185268_GT -0.029845462
## chr17_rs199533_GT -0.016176919
## UPDRS_Part_I_Summary_Score_Baseline 0.571799751
## UPDRS_Part_I_Summary_Score_Month_03 0.513655395
## UPDRS_Part_I_Summary_Score_Month_06 0.560832838
## UPDRS_Part_I_Summary_Score_Month_09 0.580590578
## UPDRS_Part_I_Summary_Score_Month_12 0.678230973
## UPDRS_Part_I_Summary_Score_Month_18 0.709959714
## UPDRS_Part_I_Summary_Score_Month_24 0.998487141
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.465558760
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.385235467
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.342998726
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.362300745
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.429227805
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.425743207
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.476288965
## UPDRS_Part_III_Summary_Score_Baseline 0.355722632
## UPDRS_Part_III_Summary_Score_Month_03 0.247841546
## UPDRS_Part_III_Summary_Score_Month_06 0.338984952
## UPDRS_Part_III_Summary_Score_Month_09 0.333256496
## UPDRS_Part_III_Summary_Score_Month_12 0.399631002
## UPDRS_Part_III_Summary_Score_Month_18 0.258670554
## UPDRS_Part_III_Summary_Score_Month_24 0.351335640
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.168481402
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.200638304
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.267701344
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.278144888
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.127599217
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.278323932
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.206997540
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.223941394
## ctrl -0.294432242
## pd 0.155681114
## swedd 0.185746434
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline
## L_insular_cortex_ComputeArea 0.0531385310
## L_insular_cortex_Volume 0.0575320599
## R_insular_cortex_ComputeArea 0.0717202190
## R_insular_cortex_Volume 0.0688973649
## L_cingulate_gyrus_ComputeArea 0.0631459668
## L_cingulate_gyrus_Volume 0.0563031963
## R_cingulate_gyrus_ComputeArea 0.0511104198
## R_cingulate_gyrus_Volume 0.0407549324
## L_caudate_ComputeArea 0.0315780450
## L_caudate_Volume 0.0276833210
## R_caudate_ComputeArea 0.0609419054
## R_caudate_Volume 0.0552115248
## L_putamen_ComputeArea 0.0709408542
## L_putamen_Volume 0.0751098373
## R_putamen_ComputeArea 0.0737509188
## R_putamen_Volume 0.0691151982
## L_hippocampus_ComputeArea 0.0769112143
## L_hippocampus_Volume 0.0722901353
## R_hippocampus_ComputeArea 0.0841166934
## R_hippocampus_Volume 0.0815620000
## cerebellum_ComputeArea 0.0005526321
## cerebellum_Volume 0.0228641729
## L_fusiform_gyrus_ComputeArea -0.0385859844
## L_fusiform_gyrus_Volume -0.0003699554
## R_fusiform_gyrus_ComputeArea 0.0116151441
## R_fusiform_gyrus_Volume 0.0365834504
## R_fusiform_gyrus_ShapeIndex 0.0276359734
## R_fusiform_gyrus_Curvedness 0.0604868986
## Sex 0.0009891118
## Weight 0.0237002270
## RG_ranked 0.5007723645
## Age 0.0440121592
## chr12_rs34637584_GT 0.0064242018
## chr17_rs11868035_GT 0.0010297685
## chr17_rs11012_GT 0.0542956802
## chr17_rs393152_GT 0.0938918008
## chr17_rs12185268_GT 0.1090552731
## chr17_rs199533_GT 0.1101159787
## UPDRS_Part_I_Summary_Score_Baseline 0.3933074282
## UPDRS_Part_I_Summary_Score_Month_03 0.2668823808
## UPDRS_Part_I_Summary_Score_Month_06 0.2287407257
## UPDRS_Part_I_Summary_Score_Month_09 0.2570367994
## UPDRS_Part_I_Summary_Score_Month_12 0.4280796638
## UPDRS_Part_I_Summary_Score_Month_18 0.3864154951
## UPDRS_Part_I_Summary_Score_Month_24 0.4655587603
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.9984871407
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.7710082057
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.6989546717
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.6015536381
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.7507429859
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.6504440099
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.7717924575
## UPDRS_Part_III_Summary_Score_Baseline 0.6132542684
## UPDRS_Part_III_Summary_Score_Month_03 0.3488154260
## UPDRS_Part_III_Summary_Score_Month_06 0.4132082862
## UPDRS_Part_III_Summary_Score_Month_09 0.4676724275
## UPDRS_Part_III_Summary_Score_Month_12 0.6032404538
## UPDRS_Part_III_Summary_Score_Month_18 0.3190741449
## UPDRS_Part_III_Summary_Score_Month_24 0.5706460007
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.2370816764
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0586931146
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.2534430956
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.3355280453
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.1009645593
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.3526249420
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.2116706037
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1883509794
## ctrl -0.5364166915
## pd 0.4193387218
## swedd 0.1157550389
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03
## L_insular_cortex_ComputeArea 0.027975538
## L_insular_cortex_Volume 0.033028559
## R_insular_cortex_ComputeArea 0.033340029
## R_insular_cortex_Volume 0.036718871
## L_cingulate_gyrus_ComputeArea 0.037076483
## L_cingulate_gyrus_Volume 0.034764884
## R_cingulate_gyrus_ComputeArea 0.016901092
## R_cingulate_gyrus_Volume 0.006328308
## L_caudate_ComputeArea 0.027637428
## L_caudate_Volume 0.025122366
## R_caudate_ComputeArea 0.033222641
## R_caudate_Volume 0.031545755
## L_putamen_ComputeArea 0.021363762
## L_putamen_Volume 0.035098673
## R_putamen_ComputeArea 0.030329230
## R_putamen_Volume 0.028199408
## L_hippocampus_ComputeArea 0.023216951
## L_hippocampus_Volume 0.024423344
## R_hippocampus_ComputeArea 0.046170378
## R_hippocampus_Volume 0.048429367
## cerebellum_ComputeArea 0.036892782
## cerebellum_Volume 0.048882304
## L_fusiform_gyrus_ComputeArea -0.008670563
## L_fusiform_gyrus_Volume 0.010130226
## R_fusiform_gyrus_ComputeArea 0.042633361
## R_fusiform_gyrus_Volume 0.052127040
## R_fusiform_gyrus_ShapeIndex 0.038482609
## R_fusiform_gyrus_Curvedness 0.085750866
## Sex -0.045955789
## Weight 0.048314679
## RG_ranked 0.259699627
## Age 0.002769452
## chr12_rs34637584_GT -0.012600826
## chr17_rs11868035_GT -0.029828353
## chr17_rs11012_GT 0.048312525
## chr17_rs393152_GT 0.122267909
## chr17_rs12185268_GT 0.099028528
## chr17_rs199533_GT 0.093728506
## UPDRS_Part_I_Summary_Score_Baseline 0.387442343
## UPDRS_Part_I_Summary_Score_Month_03 0.376176718
## UPDRS_Part_I_Summary_Score_Month_06 0.240410732
## UPDRS_Part_I_Summary_Score_Month_09 0.286590419
## UPDRS_Part_I_Summary_Score_Month_12 0.348752845
## UPDRS_Part_I_Summary_Score_Month_18 0.347666519
## UPDRS_Part_I_Summary_Score_Month_24 0.385235467
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.771008206
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.998487141
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.737707430
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.655369429
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.683999644
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.625880945
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.684372691
## UPDRS_Part_III_Summary_Score_Baseline 0.418982392
## UPDRS_Part_III_Summary_Score_Month_03 0.376941738
## UPDRS_Part_III_Summary_Score_Month_06 0.346785271
## UPDRS_Part_III_Summary_Score_Month_09 0.321543973
## UPDRS_Part_III_Summary_Score_Month_12 0.422736394
## UPDRS_Part_III_Summary_Score_Month_18 0.280667516
## UPDRS_Part_III_Summary_Score_Month_24 0.372214874
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.202583966
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.088841154
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.250329428
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.269320976
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.066651362
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.282769491
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.124271272
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.177538326
## ctrl -0.277503250
## pd 0.218090645
## swedd 0.057988208
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.0083232742
## L_insular_cortex_Volume 0.0110265571
## R_insular_cortex_ComputeArea 0.0122219965
## R_insular_cortex_Volume 0.0097393578
## L_cingulate_gyrus_ComputeArea 0.0080976145
## L_cingulate_gyrus_Volume -0.0005222306
## R_cingulate_gyrus_ComputeArea -0.0123925520
## R_cingulate_gyrus_Volume -0.0229231469
## L_caudate_ComputeArea -0.0388749035
## L_caudate_Volume -0.0387390924
## R_caudate_ComputeArea -0.0149704516
## R_caudate_Volume -0.0203948880
## L_putamen_ComputeArea 0.0156094206
## L_putamen_Volume 0.0169914587
## R_putamen_ComputeArea 0.0386800781
## R_putamen_Volume 0.0291686265
## L_hippocampus_ComputeArea 0.0370018043
## L_hippocampus_Volume 0.0342392814
## R_hippocampus_ComputeArea 0.0382842629
## R_hippocampus_Volume 0.0361997919
## cerebellum_ComputeArea 0.0588004356
## cerebellum_Volume 0.0692317944
## L_fusiform_gyrus_ComputeArea -0.0046912361
## L_fusiform_gyrus_Volume 0.0071648006
## R_fusiform_gyrus_ComputeArea 0.0313465448
## R_fusiform_gyrus_Volume 0.0452026431
## R_fusiform_gyrus_ShapeIndex 0.0102346174
## R_fusiform_gyrus_Curvedness 0.0317277872
## Sex -0.0564912243
## Weight 0.0984899626
## RG_ranked 0.2119446703
## Age 0.0221837964
## chr12_rs34637584_GT -0.0458871719
## chr17_rs11868035_GT -0.0654889727
## chr17_rs11012_GT 0.0639252096
## chr17_rs393152_GT 0.1291734825
## chr17_rs12185268_GT 0.1323746077
## chr17_rs199533_GT 0.1176181628
## UPDRS_Part_I_Summary_Score_Baseline 0.3970107393
## UPDRS_Part_I_Summary_Score_Month_03 0.3214546598
## UPDRS_Part_I_Summary_Score_Month_06 0.3094369874
## UPDRS_Part_I_Summary_Score_Month_09 0.3643179206
## UPDRS_Part_I_Summary_Score_Month_12 0.4198880209
## UPDRS_Part_I_Summary_Score_Month_18 0.3093825104
## UPDRS_Part_I_Summary_Score_Month_24 0.3429987256
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.6989546717
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.7377074300
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.9984871407
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.7889995101
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.7659420624
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.7081964805
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.6927031588
## UPDRS_Part_III_Summary_Score_Baseline 0.3848982438
## UPDRS_Part_III_Summary_Score_Month_03 0.3083762561
## UPDRS_Part_III_Summary_Score_Month_06 0.3952227866
## UPDRS_Part_III_Summary_Score_Month_09 0.3603755005
## UPDRS_Part_III_Summary_Score_Month_12 0.4083497899
## UPDRS_Part_III_Summary_Score_Month_18 0.2655309885
## UPDRS_Part_III_Summary_Score_Month_24 0.3989294446
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.1409373776
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.1577209447
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.2358052225
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.2626740645
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.1596999514
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.2903068255
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.2077010163
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.2227620451
## ctrl -0.2466620080
## pd 0.1595503106
## swedd 0.1078214214
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09
## L_insular_cortex_ComputeArea -0.015861794
## L_insular_cortex_Volume -0.011633409
## R_insular_cortex_ComputeArea -0.008228332
## R_insular_cortex_Volume -0.008671447
## L_cingulate_gyrus_ComputeArea 0.004334631
## L_cingulate_gyrus_Volume -0.003031917
## R_cingulate_gyrus_ComputeArea -0.023770264
## R_cingulate_gyrus_Volume -0.036482890
## L_caudate_ComputeArea -0.060611527
## L_caudate_Volume -0.062293457
## R_caudate_ComputeArea -0.041500376
## R_caudate_Volume -0.044212460
## L_putamen_ComputeArea -0.022211014
## L_putamen_Volume -0.015605993
## R_putamen_ComputeArea 0.005451005
## R_putamen_Volume 0.004348351
## L_hippocampus_ComputeArea 0.005987207
## L_hippocampus_Volume 0.006176881
## R_hippocampus_ComputeArea 0.020002146
## R_hippocampus_Volume 0.014200209
## cerebellum_ComputeArea 0.055161565
## cerebellum_Volume 0.056182921
## L_fusiform_gyrus_ComputeArea -0.006389189
## L_fusiform_gyrus_Volume -0.002661536
## R_fusiform_gyrus_ComputeArea 0.050570204
## R_fusiform_gyrus_Volume 0.059540176
## R_fusiform_gyrus_ShapeIndex 0.008029446
## R_fusiform_gyrus_Curvedness 0.028106940
## Sex -0.022509502
## Weight 0.070316683
## RG_ranked 0.123410868
## Age 0.033361026
## chr12_rs34637584_GT -0.066400393
## chr17_rs11868035_GT -0.044642452
## chr17_rs11012_GT 0.039455447
## chr17_rs393152_GT 0.102993345
## chr17_rs12185268_GT 0.094233071
## chr17_rs199533_GT 0.072640100
## UPDRS_Part_I_Summary_Score_Baseline 0.275841358
## UPDRS_Part_I_Summary_Score_Month_03 0.259336979
## UPDRS_Part_I_Summary_Score_Month_06 0.288889330
## UPDRS_Part_I_Summary_Score_Month_09 0.442248980
## UPDRS_Part_I_Summary_Score_Month_12 0.403036040
## UPDRS_Part_I_Summary_Score_Month_18 0.374044025
## UPDRS_Part_I_Summary_Score_Month_24 0.362300745
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.601553638
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.655369429
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.788999510
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.998487141
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.711162943
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.724142569
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.664017207
## UPDRS_Part_III_Summary_Score_Baseline 0.350432358
## UPDRS_Part_III_Summary_Score_Month_03 0.377760008
## UPDRS_Part_III_Summary_Score_Month_06 0.453332784
## UPDRS_Part_III_Summary_Score_Month_09 0.484644931
## UPDRS_Part_III_Summary_Score_Month_12 0.401685703
## UPDRS_Part_III_Summary_Score_Month_18 0.363236233
## UPDRS_Part_III_Summary_Score_Month_24 0.366656304
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.176919303
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.175312276
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.255005872
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.242925595
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.089393627
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.274514025
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.111692756
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.262047532
## ctrl -0.142397526
## pd 0.094024708
## swedd 0.059100620
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 1.250354e-02
## L_insular_cortex_Volume 1.830774e-02
## R_insular_cortex_ComputeArea 2.503443e-02
## R_insular_cortex_Volume 2.625496e-02
## L_cingulate_gyrus_ComputeArea 2.770007e-02
## L_cingulate_gyrus_Volume 2.165214e-02
## R_cingulate_gyrus_ComputeArea 8.722053e-03
## R_cingulate_gyrus_Volume -3.115880e-04
## L_caudate_ComputeArea -7.038122e-03
## L_caudate_Volume -1.329563e-02
## R_caudate_ComputeArea 6.332398e-03
## R_caudate_Volume -3.608617e-05
## L_putamen_ComputeArea 1.412308e-02
## L_putamen_Volume 2.433108e-02
## R_putamen_ComputeArea 3.804540e-02
## R_putamen_Volume 3.160980e-02
## L_hippocampus_ComputeArea 3.782907e-02
## L_hippocampus_Volume 3.336914e-02
## R_hippocampus_ComputeArea 4.983863e-02
## R_hippocampus_Volume 4.888204e-02
## cerebellum_ComputeArea 4.704854e-02
## cerebellum_Volume 5.337796e-02
## L_fusiform_gyrus_ComputeArea 3.985807e-04
## L_fusiform_gyrus_Volume 1.981899e-02
## R_fusiform_gyrus_ComputeArea 3.852434e-02
## R_fusiform_gyrus_Volume 5.538031e-02
## R_fusiform_gyrus_ShapeIndex 1.519021e-02
## R_fusiform_gyrus_Curvedness 4.910187e-02
## Sex -1.381713e-02
## Weight 8.636039e-02
## RG_ranked 5.125591e-01
## Age 6.079252e-02
## chr12_rs34637584_GT -1.601461e-03
## chr17_rs11868035_GT -4.091878e-02
## chr17_rs11012_GT 1.719963e-02
## chr17_rs393152_GT 5.741345e-02
## chr17_rs12185268_GT 7.776075e-02
## chr17_rs199533_GT 8.120983e-02
## UPDRS_Part_I_Summary_Score_Baseline 3.858118e-01
## UPDRS_Part_I_Summary_Score_Month_03 2.798454e-01
## UPDRS_Part_I_Summary_Score_Month_06 2.825863e-01
## UPDRS_Part_I_Summary_Score_Month_09 3.275154e-01
## UPDRS_Part_I_Summary_Score_Month_12 5.204538e-01
## UPDRS_Part_I_Summary_Score_Month_18 3.913414e-01
## UPDRS_Part_I_Summary_Score_Month_24 4.292278e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 7.507430e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 6.839996e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 7.659421e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 7.111629e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 9.984871e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 7.865052e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 8.548258e-01
## UPDRS_Part_III_Summary_Score_Baseline 6.039732e-01
## UPDRS_Part_III_Summary_Score_Month_03 2.968808e-01
## UPDRS_Part_III_Summary_Score_Month_06 4.510279e-01
## UPDRS_Part_III_Summary_Score_Month_09 5.055317e-01
## UPDRS_Part_III_Summary_Score_Month_12 6.937419e-01
## UPDRS_Part_III_Summary_Score_Month_18 4.308755e-01
## UPDRS_Part_III_Summary_Score_Month_24 6.490498e-01
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 2.331424e-01
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 1.365167e-01
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 3.264635e-01
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 3.699308e-01
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 9.993145e-02
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 3.194970e-01
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 2.186683e-01
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 3.121610e-01
## ctrl -5.590401e-01
## pd 4.200781e-01
## swedd 1.484400e-01
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18
## L_insular_cortex_ComputeArea 0.026247398
## L_insular_cortex_Volume 0.030569468
## R_insular_cortex_ComputeArea 0.017606869
## R_insular_cortex_Volume 0.014373701
## L_cingulate_gyrus_ComputeArea 0.027485946
## L_cingulate_gyrus_Volume 0.020133735
## R_cingulate_gyrus_ComputeArea 0.003388804
## R_cingulate_gyrus_Volume -0.002979736
## L_caudate_ComputeArea -0.011267270
## L_caudate_Volume -0.018133019
## R_caudate_ComputeArea 0.005661965
## R_caudate_Volume 0.004873309
## L_putamen_ComputeArea -0.002271194
## L_putamen_Volume 0.006709320
## R_putamen_ComputeArea 0.021429157
## R_putamen_Volume 0.017126652
## L_hippocampus_ComputeArea 0.049456286
## L_hippocampus_Volume 0.054356708
## R_hippocampus_ComputeArea 0.053521853
## R_hippocampus_Volume 0.054237921
## cerebellum_ComputeArea 0.060420324
## cerebellum_Volume 0.076007957
## L_fusiform_gyrus_ComputeArea -0.007226884
## L_fusiform_gyrus_Volume 0.012724678
## R_fusiform_gyrus_ComputeArea 0.060485020
## R_fusiform_gyrus_Volume 0.074802273
## R_fusiform_gyrus_ShapeIndex 0.014486676
## R_fusiform_gyrus_Curvedness 0.040816065
## Sex -0.034285190
## Weight 0.104130921
## RG_ranked 0.229821730
## Age 0.024968649
## chr12_rs34637584_GT 0.006178553
## chr17_rs11868035_GT -0.040297218
## chr17_rs11012_GT 0.017804424
## chr17_rs393152_GT 0.085106567
## chr17_rs12185268_GT 0.077578870
## chr17_rs199533_GT 0.073263891
## UPDRS_Part_I_Summary_Score_Baseline 0.325591166
## UPDRS_Part_I_Summary_Score_Month_03 0.270778381
## UPDRS_Part_I_Summary_Score_Month_06 0.245980687
## UPDRS_Part_I_Summary_Score_Month_09 0.387934028
## UPDRS_Part_I_Summary_Score_Month_12 0.445504987
## UPDRS_Part_I_Summary_Score_Month_18 0.440672783
## UPDRS_Part_I_Summary_Score_Month_24 0.425743207
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.650444010
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.625880945
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.708196480
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.724142569
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.786505209
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.998487141
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.792327927
## UPDRS_Part_III_Summary_Score_Baseline 0.404722470
## UPDRS_Part_III_Summary_Score_Month_03 0.337733975
## UPDRS_Part_III_Summary_Score_Month_06 0.370546280
## UPDRS_Part_III_Summary_Score_Month_09 0.442498593
## UPDRS_Part_III_Summary_Score_Month_12 0.491362167
## UPDRS_Part_III_Summary_Score_Month_18 0.545637475
## UPDRS_Part_III_Summary_Score_Month_24 0.491792006
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.241985087
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.197985094
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.294465669
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.317742666
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.103048720
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.277029157
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.180263592
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.240594961
## ctrl -0.252469316
## pd 0.186705309
## swedd 0.071970876
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24
## L_insular_cortex_ComputeArea 0.022763949
## L_insular_cortex_Volume 0.025436994
## R_insular_cortex_ComputeArea 0.034586615
## R_insular_cortex_Volume 0.030682340
## L_cingulate_gyrus_ComputeArea 0.052475930
## L_cingulate_gyrus_Volume 0.045832060
## R_cingulate_gyrus_ComputeArea 0.037454177
## R_cingulate_gyrus_Volume 0.029507875
## L_caudate_ComputeArea -0.022524265
## L_caudate_Volume -0.030337718
## R_caudate_ComputeArea 0.017881207
## R_caudate_Volume 0.012066531
## L_putamen_ComputeArea 0.029839263
## L_putamen_Volume 0.041173853
## R_putamen_ComputeArea 0.040589370
## R_putamen_Volume 0.038421192
## L_hippocampus_ComputeArea 0.051657486
## L_hippocampus_Volume 0.048314014
## R_hippocampus_ComputeArea 0.060168458
## R_hippocampus_Volume 0.058902849
## cerebellum_ComputeArea 0.041727879
## cerebellum_Volume 0.046547736
## L_fusiform_gyrus_ComputeArea 0.003841198
## L_fusiform_gyrus_Volume 0.028204993
## R_fusiform_gyrus_ComputeArea 0.057513332
## R_fusiform_gyrus_Volume 0.081066575
## R_fusiform_gyrus_ShapeIndex 0.018453330
## R_fusiform_gyrus_Curvedness 0.076056123
## Sex -0.065527300
## Weight 0.111724201
## RG_ranked 0.476069449
## Age 0.076140472
## chr12_rs34637584_GT 0.002947513
## chr17_rs11868035_GT -0.014497923
## chr17_rs11012_GT 0.005600350
## chr17_rs393152_GT 0.069109251
## chr17_rs12185268_GT 0.068602177
## chr17_rs199533_GT 0.073565710
## UPDRS_Part_I_Summary_Score_Baseline 0.343004631
## UPDRS_Part_I_Summary_Score_Month_03 0.296311473
## UPDRS_Part_I_Summary_Score_Month_06 0.243501444
## UPDRS_Part_I_Summary_Score_Month_09 0.321986433
## UPDRS_Part_I_Summary_Score_Month_12 0.457804627
## UPDRS_Part_I_Summary_Score_Month_18 0.403546398
## UPDRS_Part_I_Summary_Score_Month_24 0.476288965
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.771792457
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.684372691
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.692703159
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.664017207
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.854825810
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.792327927
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.998487141
## UPDRS_Part_III_Summary_Score_Baseline 0.596515239
## UPDRS_Part_III_Summary_Score_Month_03 0.323391652
## UPDRS_Part_III_Summary_Score_Month_06 0.436095566
## UPDRS_Part_III_Summary_Score_Month_09 0.499477071
## UPDRS_Part_III_Summary_Score_Month_12 0.648438068
## UPDRS_Part_III_Summary_Score_Month_18 0.498883682
## UPDRS_Part_III_Summary_Score_Month_24 0.696199259
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.210405090
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.136447751
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.287747962
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.367569024
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.088933070
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.289803291
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.227145267
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.275879501
## ctrl -0.526649281
## pd 0.383406940
## swedd 0.160071600
## UPDRS_Part_III_Summary_Score_Baseline
## L_insular_cortex_ComputeArea 0.040491022
## L_insular_cortex_Volume 0.038286628
## R_insular_cortex_ComputeArea 0.064828604
## R_insular_cortex_Volume 0.055095610
## L_cingulate_gyrus_ComputeArea 0.076262543
## L_cingulate_gyrus_Volume 0.073153435
## R_cingulate_gyrus_ComputeArea 0.074402788
## R_cingulate_gyrus_Volume 0.074223759
## L_caudate_ComputeArea -0.010219244
## L_caudate_Volume -0.021935069
## R_caudate_ComputeArea 0.029100248
## R_caudate_Volume 0.019617858
## L_putamen_ComputeArea 0.052597583
## L_putamen_Volume 0.057642359
## R_putamen_ComputeArea 0.074462416
## R_putamen_Volume 0.065456286
## L_hippocampus_ComputeArea 0.059319999
## L_hippocampus_Volume 0.053826185
## R_hippocampus_ComputeArea 0.056526227
## R_hippocampus_Volume 0.051448743
## cerebellum_ComputeArea 0.018290687
## cerebellum_Volume 0.010983040
## L_fusiform_gyrus_ComputeArea 0.034987439
## L_fusiform_gyrus_Volume 0.057896839
## R_fusiform_gyrus_ComputeArea -0.005766413
## R_fusiform_gyrus_Volume 0.009091695
## R_fusiform_gyrus_ShapeIndex 0.060835674
## R_fusiform_gyrus_Curvedness 0.003015616
## Sex 0.029168703
## Weight 0.052555796
## RG_ranked 0.741031393
## Age 0.133969229
## chr12_rs34637584_GT 0.005408657
## chr17_rs11868035_GT -0.031584298
## chr17_rs11012_GT 0.028967054
## chr17_rs393152_GT 0.034448336
## chr17_rs12185268_GT 0.063989273
## chr17_rs199533_GT 0.093240284
## UPDRS_Part_I_Summary_Score_Baseline 0.278593748
## UPDRS_Part_I_Summary_Score_Month_03 0.173342410
## UPDRS_Part_I_Summary_Score_Month_06 0.118509178
## UPDRS_Part_I_Summary_Score_Month_09 0.084806786
## UPDRS_Part_I_Summary_Score_Month_12 0.284098822
## UPDRS_Part_I_Summary_Score_Month_18 0.300345700
## UPDRS_Part_I_Summary_Score_Month_24 0.355722632
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.613254268
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.418982392
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.384898244
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.350432358
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.603973169
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.404722470
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.596515239
## UPDRS_Part_III_Summary_Score_Baseline 0.998487141
## UPDRS_Part_III_Summary_Score_Month_03 0.573203432
## UPDRS_Part_III_Summary_Score_Month_06 0.703194350
## UPDRS_Part_III_Summary_Score_Month_09 0.736840637
## UPDRS_Part_III_Summary_Score_Month_12 0.847865941
## UPDRS_Part_III_Summary_Score_Month_18 0.509145287
## UPDRS_Part_III_Summary_Score_Month_24 0.815583992
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.054421700
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.040412515
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.157442881
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.221678207
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.058492315
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.206158570
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.032287098
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.162738162
## ctrl -0.731710573
## pd 0.677211170
## swedd -0.014704174
## UPDRS_Part_III_Summary_Score_Month_03
## L_insular_cortex_ComputeArea 0.010966504
## L_insular_cortex_Volume 0.005247408
## R_insular_cortex_ComputeArea 0.015008696
## R_insular_cortex_Volume 0.010747353
## L_cingulate_gyrus_ComputeArea 0.046495493
## L_cingulate_gyrus_Volume 0.042972689
## R_cingulate_gyrus_ComputeArea 0.038763713
## R_cingulate_gyrus_Volume 0.030950254
## L_caudate_ComputeArea -0.047517989
## L_caudate_Volume -0.055357359
## R_caudate_ComputeArea -0.010990040
## R_caudate_Volume -0.013363547
## L_putamen_ComputeArea -0.019450806
## L_putamen_Volume -0.023925643
## R_putamen_ComputeArea 0.015508620
## R_putamen_Volume 0.013247415
## L_hippocampus_ComputeArea 0.022000458
## L_hippocampus_Volume 0.026565421
## R_hippocampus_ComputeArea 0.028967130
## R_hippocampus_Volume 0.029847123
## cerebellum_ComputeArea 0.038930795
## cerebellum_Volume 0.013559448
## L_fusiform_gyrus_ComputeArea 0.024502134
## L_fusiform_gyrus_Volume 0.025105263
## R_fusiform_gyrus_ComputeArea 0.008383078
## R_fusiform_gyrus_Volume 0.006002239
## R_fusiform_gyrus_ShapeIndex 0.008963656
## R_fusiform_gyrus_Curvedness 0.029226838
## Sex 0.026919969
## Weight 0.016660874
## RG_ranked 0.193355160
## Age 0.104874874
## chr12_rs34637584_GT -0.105283978
## chr17_rs11868035_GT -0.052475711
## chr17_rs11012_GT 0.037557054
## chr17_rs393152_GT 0.059781094
## chr17_rs12185268_GT 0.069139152
## chr17_rs199533_GT 0.072167406
## UPDRS_Part_I_Summary_Score_Baseline 0.116607655
## UPDRS_Part_I_Summary_Score_Month_03 0.171310764
## UPDRS_Part_I_Summary_Score_Month_06 0.095257627
## UPDRS_Part_I_Summary_Score_Month_09 0.174013118
## UPDRS_Part_I_Summary_Score_Month_12 0.142407403
## UPDRS_Part_I_Summary_Score_Month_18 0.294425062
## UPDRS_Part_I_Summary_Score_Month_24 0.247841546
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.348815426
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.376941738
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.308376256
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.377760008
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.296880806
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.337733975
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.323391652
## UPDRS_Part_III_Summary_Score_Baseline 0.573203432
## UPDRS_Part_III_Summary_Score_Month_03 0.998487141
## UPDRS_Part_III_Summary_Score_Month_06 0.752325594
## UPDRS_Part_III_Summary_Score_Month_09 0.651860988
## UPDRS_Part_III_Summary_Score_Month_12 0.532556367
## UPDRS_Part_III_Summary_Score_Month_18 0.514929024
## UPDRS_Part_III_Summary_Score_Month_24 0.505337358
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.000783245
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.058303177
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.096580823
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.124038363
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.002106174
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.059245223
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.040277519
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.082612693
## ctrl -0.105652738
## pd 0.254577543
## swedd -0.259368093
## UPDRS_Part_III_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.019709904
## L_insular_cortex_Volume 0.012052739
## R_insular_cortex_ComputeArea 0.038734439
## R_insular_cortex_Volume 0.030409262
## L_cingulate_gyrus_ComputeArea 0.060548055
## L_cingulate_gyrus_Volume 0.053043646
## R_cingulate_gyrus_ComputeArea 0.051764591
## R_cingulate_gyrus_Volume 0.045213591
## L_caudate_ComputeArea -0.013143915
## L_caudate_Volume -0.019767175
## R_caudate_ComputeArea 0.015580681
## R_caudate_Volume 0.009980041
## L_putamen_ComputeArea 0.001214721
## L_putamen_Volume -0.000539180
## R_putamen_ComputeArea 0.050446513
## R_putamen_Volume 0.042409008
## L_hippocampus_ComputeArea 0.035378737
## L_hippocampus_Volume 0.032072260
## R_hippocampus_ComputeArea 0.038746061
## R_hippocampus_Volume 0.029120884
## cerebellum_ComputeArea 0.003578820
## cerebellum_Volume -0.014525925
## L_fusiform_gyrus_ComputeArea 0.034606794
## L_fusiform_gyrus_Volume 0.038206873
## R_fusiform_gyrus_ComputeArea 0.012671383
## R_fusiform_gyrus_Volume 0.022269136
## R_fusiform_gyrus_ShapeIndex 0.006298056
## R_fusiform_gyrus_Curvedness 0.002362585
## Sex 0.007891802
## Weight 0.065514677
## RG_ranked 0.382273581
## Age 0.097363523
## chr12_rs34637584_GT -0.090984395
## chr17_rs11868035_GT -0.073367219
## chr17_rs11012_GT -0.052265120
## chr17_rs393152_GT -0.031337370
## chr17_rs12185268_GT -0.026943806
## chr17_rs199533_GT -0.012034706
## UPDRS_Part_I_Summary_Score_Baseline 0.234018611
## UPDRS_Part_I_Summary_Score_Month_03 0.210209573
## UPDRS_Part_I_Summary_Score_Month_06 0.248676251
## UPDRS_Part_I_Summary_Score_Month_09 0.206532578
## UPDRS_Part_I_Summary_Score_Month_12 0.285384441
## UPDRS_Part_I_Summary_Score_Month_18 0.317430520
## UPDRS_Part_I_Summary_Score_Month_24 0.338984952
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.413208286
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.346785271
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.395222787
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.453332784
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.451027934
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.370546280
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.436095566
## UPDRS_Part_III_Summary_Score_Baseline 0.703194350
## UPDRS_Part_III_Summary_Score_Month_03 0.752325594
## UPDRS_Part_III_Summary_Score_Month_06 0.998487141
## UPDRS_Part_III_Summary_Score_Month_09 0.749564638
## UPDRS_Part_III_Summary_Score_Month_12 0.696163414
## UPDRS_Part_III_Summary_Score_Month_18 0.555395374
## UPDRS_Part_III_Summary_Score_Month_24 0.652948083
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.095040741
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.032277564
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.026642271
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.098137952
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.014958690
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.188042614
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.082656386
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.145741027
## ctrl -0.320934255
## pd 0.400978886
## swedd -0.176993017
## UPDRS_Part_III_Summary_Score_Month_09
## L_insular_cortex_ComputeArea 0.0213567602
## L_insular_cortex_Volume 0.0216929170
## R_insular_cortex_ComputeArea 0.0335636714
## R_insular_cortex_Volume 0.0292713193
## L_cingulate_gyrus_ComputeArea 0.0761804738
## L_cingulate_gyrus_Volume 0.0686900952
## R_cingulate_gyrus_ComputeArea 0.0621584181
## R_cingulate_gyrus_Volume 0.0563446325
## L_caudate_ComputeArea -0.0107540023
## L_caudate_Volume -0.0152641617
## R_caudate_ComputeArea 0.0018782116
## R_caudate_Volume 0.0003608533
## L_putamen_ComputeArea 0.0392181939
## L_putamen_Volume 0.0452453229
## R_putamen_ComputeArea 0.0570562807
## R_putamen_Volume 0.0453852610
## L_hippocampus_ComputeArea 0.0182907102
## L_hippocampus_Volume 0.0185518376
## R_hippocampus_ComputeArea 0.0069126127
## R_hippocampus_Volume 0.0029068024
## cerebellum_ComputeArea 0.0139470462
## cerebellum_Volume -0.0030070310
## L_fusiform_gyrus_ComputeArea -0.0030641570
## L_fusiform_gyrus_Volume 0.0102226325
## R_fusiform_gyrus_ComputeArea -0.0175748928
## R_fusiform_gyrus_Volume 0.0010500215
## R_fusiform_gyrus_ShapeIndex 0.0347272419
## R_fusiform_gyrus_Curvedness 0.0516673459
## Sex 0.0115810019
## Weight 0.0597132246
## RG_ranked 0.4933009977
## Age 0.1599227666
## chr12_rs34637584_GT -0.0482542159
## chr17_rs11868035_GT -0.0334429078
## chr17_rs11012_GT -0.0075519418
## chr17_rs393152_GT -0.0235308670
## chr17_rs12185268_GT 0.0111927922
## chr17_rs199533_GT 0.0049876355
## UPDRS_Part_I_Summary_Score_Baseline 0.1809313429
## UPDRS_Part_I_Summary_Score_Month_03 0.1412452470
## UPDRS_Part_I_Summary_Score_Month_06 0.1151317969
## UPDRS_Part_I_Summary_Score_Month_09 0.1869285992
## UPDRS_Part_I_Summary_Score_Month_12 0.2338124752
## UPDRS_Part_I_Summary_Score_Month_18 0.2899253838
## UPDRS_Part_I_Summary_Score_Month_24 0.3332564965
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.4676724275
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.3215439733
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.3603755005
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.4846449312
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.5055317374
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.4424985935
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.4994770708
## UPDRS_Part_III_Summary_Score_Baseline 0.7368406368
## UPDRS_Part_III_Summary_Score_Month_03 0.6518609875
## UPDRS_Part_III_Summary_Score_Month_06 0.7495646376
## UPDRS_Part_III_Summary_Score_Month_09 0.9984871407
## UPDRS_Part_III_Summary_Score_Month_12 0.7878238014
## UPDRS_Part_III_Summary_Score_Month_18 0.5939214651
## UPDRS_Part_III_Summary_Score_Month_24 0.7210036651
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.0289772033
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0012867644
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.1393916000
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.1794969188
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0029106417
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.1893603164
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0266343669
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1236447457
## ctrl -0.4423589559
## pd 0.4916733115
## swedd -0.1438533891
## UPDRS_Part_III_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 0.071378789
## L_insular_cortex_Volume 0.077022464
## R_insular_cortex_ComputeArea 0.094168607
## R_insular_cortex_Volume 0.095051868
## L_cingulate_gyrus_ComputeArea 0.116407462
## L_cingulate_gyrus_Volume 0.110875482
## R_cingulate_gyrus_ComputeArea 0.100535232
## R_cingulate_gyrus_Volume 0.094805127
## L_caudate_ComputeArea 0.055569564
## L_caudate_Volume 0.049854186
## R_caudate_ComputeArea 0.065456820
## R_caudate_Volume 0.062080075
## L_putamen_ComputeArea 0.097899994
## L_putamen_Volume 0.108824626
## R_putamen_ComputeArea 0.096904461
## R_putamen_Volume 0.092900538
## L_hippocampus_ComputeArea 0.078592972
## L_hippocampus_Volume 0.079532311
## R_hippocampus_ComputeArea 0.073493618
## R_hippocampus_Volume 0.072301714
## cerebellum_ComputeArea 0.039567433
## cerebellum_Volume 0.043443507
## L_fusiform_gyrus_ComputeArea 0.044002452
## L_fusiform_gyrus_Volume 0.069290703
## R_fusiform_gyrus_ComputeArea 0.032801978
## R_fusiform_gyrus_Volume 0.051950103
## R_fusiform_gyrus_ShapeIndex 0.065052887
## R_fusiform_gyrus_Curvedness 0.036285584
## Sex 0.031121508
## Weight 0.033419371
## RG_ranked 0.711822043
## Age 0.121558829
## chr12_rs34637584_GT 0.023253787
## chr17_rs11868035_GT -0.050309936
## chr17_rs11012_GT 0.015136774
## chr17_rs393152_GT -0.002337546
## chr17_rs12185268_GT 0.033998482
## chr17_rs199533_GT 0.058775887
## UPDRS_Part_I_Summary_Score_Baseline 0.294994510
## UPDRS_Part_I_Summary_Score_Month_03 0.218996690
## UPDRS_Part_I_Summary_Score_Month_06 0.193635161
## UPDRS_Part_I_Summary_Score_Month_09 0.176119388
## UPDRS_Part_I_Summary_Score_Month_12 0.380366068
## UPDRS_Part_I_Summary_Score_Month_18 0.317332492
## UPDRS_Part_I_Summary_Score_Month_24 0.399631002
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.603240454
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.422736394
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.408349790
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.401685703
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.693741925
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.491362167
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.648438068
## UPDRS_Part_III_Summary_Score_Baseline 0.847865941
## UPDRS_Part_III_Summary_Score_Month_03 0.532556367
## UPDRS_Part_III_Summary_Score_Month_06 0.696163414
## UPDRS_Part_III_Summary_Score_Month_09 0.787823801
## UPDRS_Part_III_Summary_Score_Month_12 0.998487141
## UPDRS_Part_III_Summary_Score_Month_18 0.651246672
## UPDRS_Part_III_Summary_Score_Month_24 0.887003522
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.026860318
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.032050502
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.154433565
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.209202810
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.008798220
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.243736315
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.050105160
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.179737061
## ctrl -0.700648847
## pd 0.652544686
## swedd -0.020776625
## UPDRS_Part_III_Summary_Score_Month_18
## L_insular_cortex_ComputeArea 0.0532810494
## L_insular_cortex_Volume 0.0606503486
## R_insular_cortex_ComputeArea 0.0553526334
## R_insular_cortex_Volume 0.0595259612
## L_cingulate_gyrus_ComputeArea 0.1183927249
## L_cingulate_gyrus_Volume 0.1181135404
## R_cingulate_gyrus_ComputeArea 0.1019113714
## R_cingulate_gyrus_Volume 0.1057668749
## L_caudate_ComputeArea 0.0257457345
## L_caudate_Volume 0.0202883465
## R_caudate_ComputeArea 0.0437063806
## R_caudate_Volume 0.0546703481
## L_putamen_ComputeArea 0.0446577546
## L_putamen_Volume 0.0614743971
## R_putamen_ComputeArea 0.0410614044
## R_putamen_Volume 0.0507030430
## L_hippocampus_ComputeArea 0.0756294129
## L_hippocampus_Volume 0.0895046788
## R_hippocampus_ComputeArea 0.0426970471
## R_hippocampus_Volume 0.0488568406
## cerebellum_ComputeArea 0.0218023025
## cerebellum_Volume 0.0310907047
## L_fusiform_gyrus_ComputeArea 0.0131610496
## L_fusiform_gyrus_Volume 0.0413499139
## R_fusiform_gyrus_ComputeArea 0.0414745722
## R_fusiform_gyrus_Volume 0.0557390211
## R_fusiform_gyrus_ShapeIndex 0.0607349001
## R_fusiform_gyrus_Curvedness 0.0121428851
## Sex -0.0426707812
## Weight 0.0882613369
## RG_ranked 0.2373504953
## Age 0.0748411801
## chr12_rs34637584_GT 0.0035214414
## chr17_rs11868035_GT -0.0420119276
## chr17_rs11012_GT 0.0008641251
## chr17_rs393152_GT 0.0555292664
## chr17_rs12185268_GT 0.0474331172
## chr17_rs199533_GT 0.0667079770
## UPDRS_Part_I_Summary_Score_Baseline 0.1062937705
## UPDRS_Part_I_Summary_Score_Month_03 0.1765775809
## UPDRS_Part_I_Summary_Score_Month_06 0.1075335410
## UPDRS_Part_I_Summary_Score_Month_09 0.2028128748
## UPDRS_Part_I_Summary_Score_Month_12 0.1881687741
## UPDRS_Part_I_Summary_Score_Month_18 0.3174681931
## UPDRS_Part_I_Summary_Score_Month_24 0.2586705536
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.3190741449
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.2806675162
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.2655309885
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.3632362331
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.4308754992
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.5456374748
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.4988836823
## UPDRS_Part_III_Summary_Score_Baseline 0.5091452868
## UPDRS_Part_III_Summary_Score_Month_03 0.5149290244
## UPDRS_Part_III_Summary_Score_Month_06 0.5553953737
## UPDRS_Part_III_Summary_Score_Month_09 0.5939214651
## UPDRS_Part_III_Summary_Score_Month_12 0.6512466718
## UPDRS_Part_III_Summary_Score_Month_18 0.9984871407
## UPDRS_Part_III_Summary_Score_Month_24 0.6748392597
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.0138123893
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.0265244955
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.1472835768
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.1539642983
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0381802108
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0110502995
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0266698303
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1217115097
## ctrl -0.1855943105
## pd 0.2614498655
## swedd -0.1508619672
## UPDRS_Part_III_Summary_Score_Month_24
## L_insular_cortex_ComputeArea 0.060024741
## L_insular_cortex_Volume 0.061617864
## R_insular_cortex_ComputeArea 0.078560086
## R_insular_cortex_Volume 0.077345995
## L_cingulate_gyrus_ComputeArea 0.102872197
## L_cingulate_gyrus_Volume 0.098196428
## R_cingulate_gyrus_ComputeArea 0.094117483
## R_cingulate_gyrus_Volume 0.091290367
## L_caudate_ComputeArea 0.003945830
## L_caudate_Volume -0.006445136
## R_caudate_ComputeArea 0.036377236
## R_caudate_Volume 0.034424317
## L_putamen_ComputeArea 0.073923028
## L_putamen_Volume 0.081332044
## R_putamen_ComputeArea 0.074552833
## R_putamen_Volume 0.071366121
## L_hippocampus_ComputeArea 0.102191551
## L_hippocampus_Volume 0.099331026
## R_hippocampus_ComputeArea 0.070484596
## R_hippocampus_Volume 0.067136430
## cerebellum_ComputeArea 0.052736073
## cerebellum_Volume 0.050569630
## L_fusiform_gyrus_ComputeArea 0.053532262
## L_fusiform_gyrus_Volume 0.074180097
## R_fusiform_gyrus_ComputeArea 0.026122644
## R_fusiform_gyrus_Volume 0.046127026
## R_fusiform_gyrus_ShapeIndex 0.051232901
## R_fusiform_gyrus_Curvedness 0.040231342
## Sex -0.045089479
## Weight 0.087959195
## RG_ranked 0.699758564
## Age 0.153805108
## chr12_rs34637584_GT 0.015323257
## chr17_rs11868035_GT -0.013551036
## chr17_rs11012_GT 0.017188050
## chr17_rs393152_GT 0.009458950
## chr17_rs12185268_GT 0.033191188
## chr17_rs199533_GT 0.055653464
## UPDRS_Part_I_Summary_Score_Baseline 0.212456600
## UPDRS_Part_I_Summary_Score_Month_03 0.172099204
## UPDRS_Part_I_Summary_Score_Month_06 0.105860002
## UPDRS_Part_I_Summary_Score_Month_09 0.097490049
## UPDRS_Part_I_Summary_Score_Month_12 0.301704354
## UPDRS_Part_I_Summary_Score_Month_18 0.302680410
## UPDRS_Part_I_Summary_Score_Month_24 0.351335640
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.570646001
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.372214874
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.398929445
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.366656304
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.649049839
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.491792006
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.696199259
## UPDRS_Part_III_Summary_Score_Baseline 0.815583992
## UPDRS_Part_III_Summary_Score_Month_03 0.505337358
## UPDRS_Part_III_Summary_Score_Month_06 0.652948083
## UPDRS_Part_III_Summary_Score_Month_09 0.721003665
## UPDRS_Part_III_Summary_Score_Month_12 0.887003522
## UPDRS_Part_III_Summary_Score_Month_18 0.674839260
## UPDRS_Part_III_Summary_Score_Month_24 0.998487141
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.013954644
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.057921085
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.151470323
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.204386600
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.029146237
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.201478594
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.087644273
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.177637993
## ctrl -0.680253500
## pd 0.649267971
## swedd -0.045960234
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.0543908795
## L_insular_cortex_Volume -0.0595919023
## R_insular_cortex_ComputeArea -0.0568531306
## R_insular_cortex_Volume -0.0708987221
## L_cingulate_gyrus_ComputeArea -0.0537514175
## L_cingulate_gyrus_Volume -0.0675157873
## R_cingulate_gyrus_ComputeArea -0.0427526720
## R_cingulate_gyrus_Volume -0.0481058264
## L_caudate_ComputeArea -0.0404727744
## L_caudate_Volume -0.0425236651
## R_caudate_ComputeArea -0.0234879885
## R_caudate_Volume -0.0206312215
## L_putamen_ComputeArea -0.0749546856
## L_putamen_Volume -0.0696555142
## R_putamen_ComputeArea -0.0532813976
## R_putamen_Volume -0.0601967967
## L_hippocampus_ComputeArea -0.0435594335
## L_hippocampus_Volume -0.0487643303
## R_hippocampus_ComputeArea -0.0628086914
## R_hippocampus_Volume -0.0538011619
## cerebellum_ComputeArea 0.0060978008
## cerebellum_Volume -0.0137251360
## L_fusiform_gyrus_ComputeArea -0.0198683605
## L_fusiform_gyrus_Volume -0.0223693611
## R_fusiform_gyrus_ComputeArea -0.0784382193
## R_fusiform_gyrus_Volume -0.0917120172
## R_fusiform_gyrus_ShapeIndex 0.0125230864
## R_fusiform_gyrus_Curvedness 0.0006035692
## Sex -0.0012506416
## Weight 0.0178685170
## RG_ranked -0.0063069448
## Age 0.0003149907
## chr12_rs34637584_GT 0.0219272863
## chr17_rs11868035_GT 0.0747803740
## chr17_rs11012_GT -0.0682250327
## chr17_rs393152_GT -0.0450143748
## chr17_rs12185268_GT -0.0360165959
## chr17_rs199533_GT -0.0309864247
## UPDRS_Part_I_Summary_Score_Baseline 0.2302962180
## UPDRS_Part_I_Summary_Score_Month_03 0.1129874473
## UPDRS_Part_I_Summary_Score_Month_06 0.0882048586
## UPDRS_Part_I_Summary_Score_Month_09 0.1907214563
## UPDRS_Part_I_Summary_Score_Month_12 0.2214764271
## UPDRS_Part_I_Summary_Score_Month_18 0.2011629695
## UPDRS_Part_I_Summary_Score_Month_24 0.1684814019
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.2370816764
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.2025839660
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1409373776
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.1769193030
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.2331423765
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.2419850866
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.2104050901
## UPDRS_Part_III_Summary_Score_Baseline 0.0544217001
## UPDRS_Part_III_Summary_Score_Month_03 -0.0007832450
## UPDRS_Part_III_Summary_Score_Month_06 -0.0950407408
## UPDRS_Part_III_Summary_Score_Month_09 0.0289772033
## UPDRS_Part_III_Summary_Score_Month_12 0.0268603182
## UPDRS_Part_III_Summary_Score_Month_18 0.0138123893
## UPDRS_Part_III_Summary_Score_Month_24 -0.0139546442
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.9984871407
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.7258373000
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.6147744929
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.5786670706
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.1249122919
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0531177825
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.1800038119
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1698940356
## ctrl -0.0673784621
## pd -0.0729859377
## swedd 0.2207019154
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06
## L_insular_cortex_ComputeArea -0.0570043720
## L_insular_cortex_Volume -0.0685832800
## R_insular_cortex_ComputeArea -0.0755113167
## R_insular_cortex_Volume -0.0882969653
## L_cingulate_gyrus_ComputeArea -0.0567344962
## L_cingulate_gyrus_Volume -0.0764717009
## R_cingulate_gyrus_ComputeArea -0.0537803888
## R_cingulate_gyrus_Volume -0.0643628629
## L_caudate_ComputeArea -0.0865645719
## L_caudate_Volume -0.0905019093
## R_caudate_ComputeArea -0.0658772178
## R_caudate_Volume -0.0690970586
## L_putamen_ComputeArea -0.0966791164
## L_putamen_Volume -0.1069463495
## R_putamen_ComputeArea -0.0677242214
## R_putamen_Volume -0.0809887398
## L_hippocampus_ComputeArea -0.0640731047
## L_hippocampus_Volume -0.0667635080
## R_hippocampus_ComputeArea -0.0922666154
## R_hippocampus_Volume -0.0816475357
## cerebellum_ComputeArea 0.0488885502
## cerebellum_Volume 0.0175219077
## L_fusiform_gyrus_ComputeArea 0.0207068192
## L_fusiform_gyrus_Volume 0.0042051581
## R_fusiform_gyrus_ComputeArea -0.0481492894
## R_fusiform_gyrus_Volume -0.0760829715
## R_fusiform_gyrus_ShapeIndex -0.0117425590
## R_fusiform_gyrus_Curvedness -0.0421642319
## Sex -0.0001388786
## Weight 0.0724759669
## RG_ranked -0.1482884821
## Age 0.0259510618
## chr12_rs34637584_GT -0.0334411274
## chr17_rs11868035_GT -0.0192519656
## chr17_rs11012_GT -0.0485666307
## chr17_rs393152_GT -0.0122020373
## chr17_rs12185268_GT -0.0069022072
## chr17_rs199533_GT -0.0083136645
## UPDRS_Part_I_Summary_Score_Baseline 0.1782895521
## UPDRS_Part_I_Summary_Score_Month_03 0.1855210392
## UPDRS_Part_I_Summary_Score_Month_06 0.1334926748
## UPDRS_Part_I_Summary_Score_Month_09 0.2185956665
## UPDRS_Part_I_Summary_Score_Month_12 0.2385601834
## UPDRS_Part_I_Summary_Score_Month_18 0.2163403704
## UPDRS_Part_I_Summary_Score_Month_24 0.2006383045
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.0586931146
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0888411540
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1577209447
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.1753122756
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.1365167251
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.1979850940
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.1364477510
## UPDRS_Part_III_Summary_Score_Baseline -0.0404125152
## UPDRS_Part_III_Summary_Score_Month_03 0.0583031771
## UPDRS_Part_III_Summary_Score_Month_06 -0.0322775638
## UPDRS_Part_III_Summary_Score_Month_09 0.0012867644
## UPDRS_Part_III_Summary_Score_Month_12 -0.0320505024
## UPDRS_Part_III_Summary_Score_Month_18 0.0265244955
## UPDRS_Part_III_Summary_Score_Month_24 -0.0579210853
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.7258373000
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.9984871407
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.6372735832
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.6364149963
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.0776378585
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0289818700
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.1563260570
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1086252585
## ctrl 0.0971261825
## pd -0.1805388864
## swedd 0.1506720526
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12
## L_insular_cortex_ComputeArea -0.082590149
## L_insular_cortex_Volume -0.083690078
## R_insular_cortex_ComputeArea -0.083411334
## R_insular_cortex_Volume -0.091514369
## L_cingulate_gyrus_ComputeArea -0.065593500
## L_cingulate_gyrus_Volume -0.076799045
## R_cingulate_gyrus_ComputeArea -0.074670465
## R_cingulate_gyrus_Volume -0.080159946
## L_caudate_ComputeArea -0.079849343
## L_caudate_Volume -0.085052176
## R_caudate_ComputeArea -0.077594278
## R_caudate_Volume -0.071351882
## L_putamen_ComputeArea -0.088400059
## L_putamen_Volume -0.093138707
## R_putamen_ComputeArea -0.066065666
## R_putamen_Volume -0.082560111
## L_hippocampus_ComputeArea -0.088166228
## L_hippocampus_Volume -0.091897056
## R_hippocampus_ComputeArea -0.076313166
## R_hippocampus_Volume -0.070603665
## cerebellum_ComputeArea 0.013183963
## cerebellum_Volume -0.023710825
## L_fusiform_gyrus_ComputeArea -0.055513642
## L_fusiform_gyrus_Volume -0.064559163
## R_fusiform_gyrus_ComputeArea -0.057340822
## R_fusiform_gyrus_Volume -0.087056651
## R_fusiform_gyrus_ShapeIndex 0.062710997
## R_fusiform_gyrus_Curvedness 0.017398512
## Sex -0.050971079
## Weight 0.140115012
## RG_ranked 0.097291476
## Age -0.003496751
## chr12_rs34637584_GT -0.002799944
## chr17_rs11868035_GT -0.012825854
## chr17_rs11012_GT -0.031788229
## chr17_rs393152_GT -0.002754302
## chr17_rs12185268_GT 0.006307006
## chr17_rs199533_GT 0.008009530
## UPDRS_Part_I_Summary_Score_Baseline 0.206118503
## UPDRS_Part_I_Summary_Score_Month_03 0.226182310
## UPDRS_Part_I_Summary_Score_Month_06 0.212931428
## UPDRS_Part_I_Summary_Score_Month_09 0.213160139
## UPDRS_Part_I_Summary_Score_Month_12 0.267898694
## UPDRS_Part_I_Summary_Score_Month_18 0.288145482
## UPDRS_Part_I_Summary_Score_Month_24 0.267701344
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.253443096
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.250329428
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.235805222
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.255005872
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.326463452
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.294465669
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.287747962
## UPDRS_Part_III_Summary_Score_Baseline 0.157442881
## UPDRS_Part_III_Summary_Score_Month_03 0.096580823
## UPDRS_Part_III_Summary_Score_Month_06 0.026642271
## UPDRS_Part_III_Summary_Score_Month_09 0.139391600
## UPDRS_Part_III_Summary_Score_Month_12 0.154433565
## UPDRS_Part_III_Summary_Score_Month_18 0.147283577
## UPDRS_Part_III_Summary_Score_Month_24 0.151470323
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.614774493
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.637273583
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.998487141
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.728218273
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.072439206
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.119698099
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.126746290
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.139974319
## ctrl -0.133066259
## pd 0.055122770
## swedd 0.108943683
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.021140102
## L_insular_cortex_Volume -0.027240511
## R_insular_cortex_ComputeArea -0.026632249
## R_insular_cortex_Volume -0.039071842
## L_cingulate_gyrus_ComputeArea -0.015904575
## L_cingulate_gyrus_Volume -0.024249951
## R_cingulate_gyrus_ComputeArea -0.023694678
## R_cingulate_gyrus_Volume -0.028430315
## L_caudate_ComputeArea -0.046044622
## L_caudate_Volume -0.056109727
## R_caudate_ComputeArea -0.016032522
## R_caudate_Volume -0.016541649
## L_putamen_ComputeArea -0.042360034
## L_putamen_Volume -0.047394360
## R_putamen_ComputeArea -0.008364588
## R_putamen_Volume -0.020643648
## L_hippocampus_ComputeArea -0.035179962
## L_hippocampus_Volume -0.037477481
## R_hippocampus_ComputeArea -0.048227061
## R_hippocampus_Volume -0.042670225
## cerebellum_ComputeArea 0.057040525
## cerebellum_Volume 0.047002920
## L_fusiform_gyrus_ComputeArea -0.029044259
## L_fusiform_gyrus_Volume -0.008318142
## R_fusiform_gyrus_ComputeArea -0.065368316
## R_fusiform_gyrus_Volume -0.073989149
## R_fusiform_gyrus_ShapeIndex -0.007846707
## R_fusiform_gyrus_Curvedness -0.020368869
## Sex -0.093964909
## Weight 0.159401290
## RG_ranked 0.152434060
## Age -0.040394711
## chr12_rs34637584_GT -0.022284138
## chr17_rs11868035_GT -0.054786090
## chr17_rs11012_GT -0.020993163
## chr17_rs393152_GT 0.015647247
## chr17_rs12185268_GT 0.037541226
## chr17_rs199533_GT 0.055029721
## UPDRS_Part_I_Summary_Score_Baseline 0.216820387
## UPDRS_Part_I_Summary_Score_Month_03 0.218688022
## UPDRS_Part_I_Summary_Score_Month_06 0.117935688
## UPDRS_Part_I_Summary_Score_Month_09 0.198240875
## UPDRS_Part_I_Summary_Score_Month_12 0.247800781
## UPDRS_Part_I_Summary_Score_Month_18 0.242071960
## UPDRS_Part_I_Summary_Score_Month_24 0.278144888
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.335528045
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.269320976
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.262674064
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.242925595
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.369930817
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.317742666
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.367569024
## UPDRS_Part_III_Summary_Score_Baseline 0.221678207
## UPDRS_Part_III_Summary_Score_Month_03 0.124038363
## UPDRS_Part_III_Summary_Score_Month_06 0.098137952
## UPDRS_Part_III_Summary_Score_Month_09 0.179496919
## UPDRS_Part_III_Summary_Score_Month_12 0.209202810
## UPDRS_Part_III_Summary_Score_Month_18 0.153964298
## UPDRS_Part_III_Summary_Score_Month_24 0.204386600
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.578667071
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.636414996
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.728218273
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.998487141
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.113845664
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.078444390
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.148038274
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.177861210
## ctrl -0.176082052
## pd 0.115957871
## swedd 0.073587408
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline
## L_insular_cortex_ComputeArea -0.042011240
## L_insular_cortex_Volume -0.038950951
## R_insular_cortex_ComputeArea -0.026027848
## R_insular_cortex_Volume -0.035882166
## L_cingulate_gyrus_ComputeArea -0.023092986
## L_cingulate_gyrus_Volume -0.033185577
## R_cingulate_gyrus_ComputeArea -0.014664424
## R_cingulate_gyrus_Volume -0.030629327
## L_caudate_ComputeArea -0.033765430
## L_caudate_Volume -0.043978959
## R_caudate_ComputeArea -0.028751022
## R_caudate_Volume -0.041777675
## L_putamen_ComputeArea -0.055312222
## L_putamen_Volume -0.061847521
## R_putamen_ComputeArea -0.023246790
## R_putamen_Volume -0.032214239
## L_hippocampus_ComputeArea -0.029536521
## L_hippocampus_Volume -0.035117469
## R_hippocampus_ComputeArea -0.063220710
## R_hippocampus_Volume -0.060323509
## cerebellum_ComputeArea -0.041793813
## cerebellum_Volume -0.059866147
## L_fusiform_gyrus_ComputeArea -0.040267237
## L_fusiform_gyrus_Volume -0.052641834
## R_fusiform_gyrus_ComputeArea -0.102180748
## R_fusiform_gyrus_Volume -0.099814997
## R_fusiform_gyrus_ShapeIndex -0.089054450
## R_fusiform_gyrus_Curvedness 0.011115319
## Sex -0.017460258
## Weight 0.031037359
## RG_ranked 0.019963975
## Age -0.063324552
## chr12_rs34637584_GT -0.037564642
## chr17_rs11868035_GT -0.003394086
## chr17_rs11012_GT -0.027497323
## chr17_rs393152_GT 0.014262400
## chr17_rs12185268_GT -0.011359120
## chr17_rs199533_GT -0.030808385
## UPDRS_Part_I_Summary_Score_Baseline 0.197858260
## UPDRS_Part_I_Summary_Score_Month_03 0.128273204
## UPDRS_Part_I_Summary_Score_Month_06 0.160051808
## UPDRS_Part_I_Summary_Score_Month_09 0.132673407
## UPDRS_Part_I_Summary_Score_Month_12 0.115914668
## UPDRS_Part_I_Summary_Score_Month_18 0.133769381
## UPDRS_Part_I_Summary_Score_Month_24 0.127599217
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.100964559
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.066651362
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.159699951
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.089393627
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.099931452
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.103048720
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.088933070
## UPDRS_Part_III_Summary_Score_Baseline 0.058492315
## UPDRS_Part_III_Summary_Score_Month_03 0.002106174
## UPDRS_Part_III_Summary_Score_Month_06 0.014958690
## UPDRS_Part_III_Summary_Score_Month_09 -0.002910642
## UPDRS_Part_III_Summary_Score_Month_12 -0.008798220
## UPDRS_Part_III_Summary_Score_Month_18 -0.038180211
## UPDRS_Part_III_Summary_Score_Month_24 0.029146237
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.124912292
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.077637859
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.072439206
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.113845664
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.998487141
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.520822080
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.454180249
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.341524757
## ctrl -0.046120816
## pd -0.005872964
## swedd 0.078741081
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06
## L_insular_cortex_ComputeArea 0.011926534
## L_insular_cortex_Volume 0.010744994
## R_insular_cortex_ComputeArea 0.021764080
## R_insular_cortex_Volume 0.012213373
## L_cingulate_gyrus_ComputeArea 0.030477534
## L_cingulate_gyrus_Volume 0.016680700
## R_cingulate_gyrus_ComputeArea 0.018478562
## R_cingulate_gyrus_Volume 0.002264916
## L_caudate_ComputeArea 0.067568341
## L_caudate_Volume 0.064301448
## R_caudate_ComputeArea 0.038615991
## R_caudate_Volume 0.030727345
## L_putamen_ComputeArea -0.010641773
## L_putamen_Volume -0.007045567
## R_putamen_ComputeArea 0.013845451
## R_putamen_Volume 0.006467705
## L_hippocampus_ComputeArea 0.002166421
## L_hippocampus_Volume -0.009633582
## R_hippocampus_ComputeArea 0.032972742
## R_hippocampus_Volume 0.027247222
## cerebellum_ComputeArea -0.056890634
## cerebellum_Volume -0.053178838
## L_fusiform_gyrus_ComputeArea -0.022481580
## L_fusiform_gyrus_Volume -0.022971530
## R_fusiform_gyrus_ComputeArea -0.051902886
## R_fusiform_gyrus_Volume -0.045983001
## R_fusiform_gyrus_ShapeIndex -0.042888391
## R_fusiform_gyrus_Curvedness 0.093009464
## Sex 0.039287852
## Weight 0.032194931
## RG_ranked 0.217620432
## Age -0.047940544
## chr12_rs34637584_GT -0.047593320
## chr17_rs11868035_GT -0.035572521
## chr17_rs11012_GT -0.013336866
## chr17_rs393152_GT 0.029925506
## chr17_rs12185268_GT -0.003342712
## chr17_rs199533_GT -0.001222454
## UPDRS_Part_I_Summary_Score_Baseline 0.301660905
## UPDRS_Part_I_Summary_Score_Month_03 0.187485509
## UPDRS_Part_I_Summary_Score_Month_06 0.336818474
## UPDRS_Part_I_Summary_Score_Month_09 0.237013696
## UPDRS_Part_I_Summary_Score_Month_12 0.319867776
## UPDRS_Part_I_Summary_Score_Month_18 0.341320814
## UPDRS_Part_I_Summary_Score_Month_24 0.278323932
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.352624942
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.282769491
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.290306825
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.274514025
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.319497035
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.277029157
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.289803291
## UPDRS_Part_III_Summary_Score_Baseline 0.206158570
## UPDRS_Part_III_Summary_Score_Month_03 0.059245223
## UPDRS_Part_III_Summary_Score_Month_06 0.188042614
## UPDRS_Part_III_Summary_Score_Month_09 0.189360316
## UPDRS_Part_III_Summary_Score_Month_12 0.243736315
## UPDRS_Part_III_Summary_Score_Month_18 0.011050299
## UPDRS_Part_III_Summary_Score_Month_24 0.201478594
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.053117783
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.028981870
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.119698099
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.078444390
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.520822080
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.998487141
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.588503026
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.453712966
## ctrl -0.245177121
## pd 0.171211657
## swedd 0.086464282
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12
## L_insular_cortex_ComputeArea 0.016987497
## L_insular_cortex_Volume 0.013409962
## R_insular_cortex_ComputeArea 0.022099506
## R_insular_cortex_Volume 0.012454452
## L_cingulate_gyrus_ComputeArea 0.041497070
## L_cingulate_gyrus_Volume 0.028997696
## R_cingulate_gyrus_ComputeArea 0.034777948
## R_cingulate_gyrus_Volume 0.025008467
## L_caudate_ComputeArea 0.009765524
## L_caudate_Volume 0.005819086
## R_caudate_ComputeArea 0.047524471
## R_caudate_Volume 0.037550759
## L_putamen_ComputeArea 0.007799782
## L_putamen_Volume 0.008594726
## R_putamen_ComputeArea 0.022941261
## R_putamen_Volume 0.025542464
## L_hippocampus_ComputeArea 0.045509917
## L_hippocampus_Volume 0.034645545
## R_hippocampus_ComputeArea 0.063518265
## R_hippocampus_Volume 0.057081293
## cerebellum_ComputeArea -0.002855730
## cerebellum_Volume -0.007984883
## L_fusiform_gyrus_ComputeArea 0.012713857
## L_fusiform_gyrus_Volume 0.015627978
## R_fusiform_gyrus_ComputeArea 0.007382102
## R_fusiform_gyrus_Volume 0.012193137
## R_fusiform_gyrus_ShapeIndex -0.082733066
## R_fusiform_gyrus_Curvedness 0.017555037
## Sex 0.057234383
## Weight 0.006894847
## RG_ranked 0.027083207
## Age -0.026011925
## chr12_rs34637584_GT -0.028347601
## chr17_rs11868035_GT -0.088072086
## chr17_rs11012_GT -0.015960408
## chr17_rs393152_GT 0.045725918
## chr17_rs12185268_GT 0.017640204
## chr17_rs199533_GT 0.014480980
## UPDRS_Part_I_Summary_Score_Baseline 0.252978022
## UPDRS_Part_I_Summary_Score_Month_03 0.163807885
## UPDRS_Part_I_Summary_Score_Month_06 0.309374418
## UPDRS_Part_I_Summary_Score_Month_09 0.215282054
## UPDRS_Part_I_Summary_Score_Month_12 0.284387093
## UPDRS_Part_I_Summary_Score_Month_18 0.232313369
## UPDRS_Part_I_Summary_Score_Month_24 0.206997540
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.211670604
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.124271272
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.207701016
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.111692756
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.218668329
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.180263592
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.227145267
## UPDRS_Part_III_Summary_Score_Baseline 0.032287098
## UPDRS_Part_III_Summary_Score_Month_03 0.040277519
## UPDRS_Part_III_Summary_Score_Month_06 0.082656386
## UPDRS_Part_III_Summary_Score_Month_09 -0.026634367
## UPDRS_Part_III_Summary_Score_Month_12 0.050105160
## UPDRS_Part_III_Summary_Score_Month_18 -0.026669830
## UPDRS_Part_III_Summary_Score_Month_24 0.087644273
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.180003812
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.156326057
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.126746290
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.148038274
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.454180249
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.588503026
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.998487141
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.424695883
## ctrl -0.061094119
## pd -0.006621527
## swedd 0.102404610
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24
## L_insular_cortex_ComputeArea -0.0256699748
## L_insular_cortex_Volume -0.0332771093
## R_insular_cortex_ComputeArea 0.0114284059
## R_insular_cortex_Volume -0.0009180699
## L_cingulate_gyrus_ComputeArea -0.0042350004
## L_cingulate_gyrus_Volume -0.0104606281
## R_cingulate_gyrus_ComputeArea 0.0126123555
## R_cingulate_gyrus_Volume 0.0075791043
## L_caudate_ComputeArea -0.0148795652
## L_caudate_Volume -0.0211244279
## R_caudate_ComputeArea 0.0094932370
## R_caudate_Volume 0.0050884515
## L_putamen_ComputeArea -0.0303330645
## L_putamen_Volume -0.0299721818
## R_putamen_ComputeArea -0.0213780049
## R_putamen_Volume -0.0186388604
## L_hippocampus_ComputeArea 0.0219636425
## L_hippocampus_Volume 0.0147363674
## R_hippocampus_ComputeArea 0.0560007657
## R_hippocampus_Volume 0.0484958436
## cerebellum_ComputeArea 0.0043154849
## cerebellum_Volume 0.0180607587
## L_fusiform_gyrus_ComputeArea -0.0279824823
## L_fusiform_gyrus_Volume -0.0115711392
## R_fusiform_gyrus_ComputeArea 0.0250351341
## R_fusiform_gyrus_Volume 0.0402510059
## R_fusiform_gyrus_ShapeIndex -0.0050825626
## R_fusiform_gyrus_Curvedness 0.0234569967
## Sex -0.0402640555
## Weight 0.0538373716
## RG_ranked 0.1398016236
## Age -0.0190103623
## chr12_rs34637584_GT -0.0277906325
## chr17_rs11868035_GT -0.0414463611
## chr17_rs11012_GT -0.0266998754
## chr17_rs393152_GT 0.0116394990
## chr17_rs12185268_GT -0.0117262532
## chr17_rs199533_GT 0.0140394982
## UPDRS_Part_I_Summary_Score_Baseline 0.2244256796
## UPDRS_Part_I_Summary_Score_Month_03 0.2365836928
## UPDRS_Part_I_Summary_Score_Month_06 0.2715439892
## UPDRS_Part_I_Summary_Score_Month_09 0.2660363091
## UPDRS_Part_I_Summary_Score_Month_12 0.2830252640
## UPDRS_Part_I_Summary_Score_Month_18 0.2772539349
## UPDRS_Part_I_Summary_Score_Month_24 0.2239413937
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.1883509794
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.1775383257
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.2227620451
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.2620475317
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.3121609740
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.2405949610
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.2758795013
## UPDRS_Part_III_Summary_Score_Baseline 0.1627381620
## UPDRS_Part_III_Summary_Score_Month_03 0.0826126928
## UPDRS_Part_III_Summary_Score_Month_06 0.1457410273
## UPDRS_Part_III_Summary_Score_Month_09 0.1236447457
## UPDRS_Part_III_Summary_Score_Month_12 0.1797370611
## UPDRS_Part_III_Summary_Score_Month_18 0.1217115097
## UPDRS_Part_III_Summary_Score_Month_24 0.1776379929
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.1698940356
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.1086252585
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.1399743187
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.1778612099
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.3415247574
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.4537129661
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.4246958831
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.9984871407
## ctrl -0.1449725634
## pd 0.1214330197
## swedd 0.0179913713
## ctrl
## L_insular_cortex_ComputeArea -0.058317848
## L_insular_cortex_Volume -0.060824309
## R_insular_cortex_ComputeArea -0.087696331
## R_insular_cortex_Volume -0.088924825
## L_cingulate_gyrus_ComputeArea -0.072406619
## L_cingulate_gyrus_Volume -0.069483626
## R_cingulate_gyrus_ComputeArea -0.058689971
## R_cingulate_gyrus_Volume -0.058740811
## L_caudate_ComputeArea -0.068122496
## L_caudate_Volume -0.063527151
## R_caudate_ComputeArea -0.055072416
## R_caudate_Volume -0.049928761
## L_putamen_ComputeArea -0.096507429
## L_putamen_Volume -0.101723116
## R_putamen_ComputeArea -0.085595017
## R_putamen_Volume -0.076695602
## L_hippocampus_ComputeArea -0.057322069
## L_hippocampus_Volume -0.048559265
## R_hippocampus_ComputeArea -0.058081232
## R_hippocampus_Volume -0.053043896
## cerebellum_ComputeArea -0.010260821
## cerebellum_Volume -0.017842540
## L_fusiform_gyrus_ComputeArea -0.044913834
## L_fusiform_gyrus_Volume -0.066199104
## R_fusiform_gyrus_ComputeArea -0.000863840
## R_fusiform_gyrus_Volume -0.020764460
## R_fusiform_gyrus_ShapeIndex -0.050747736
## R_fusiform_gyrus_Curvedness -0.009085629
## Sex -0.056957419
## Weight -0.006013417
## RG_ranked -0.942578806
## Age -0.050491517
## chr12_rs34637584_GT -0.055341241
## chr17_rs11868035_GT -0.006226789
## chr17_rs11012_GT -0.010098915
## chr17_rs393152_GT 0.017770429
## chr17_rs12185268_GT -0.019121286
## chr17_rs199533_GT -0.045353907
## UPDRS_Part_I_Summary_Score_Baseline -0.251538438
## UPDRS_Part_I_Summary_Score_Month_03 -0.087549493
## UPDRS_Part_I_Summary_Score_Month_06 -0.075991313
## UPDRS_Part_I_Summary_Score_Month_09 0.003094521
## UPDRS_Part_I_Summary_Score_Month_12 -0.298074345
## UPDRS_Part_I_Summary_Score_Month_18 -0.177651634
## UPDRS_Part_I_Summary_Score_Month_24 -0.294432242
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline -0.536416691
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 -0.277503250
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 -0.246662008
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 -0.142397526
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 -0.559040095
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 -0.252469316
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 -0.526649281
## UPDRS_Part_III_Summary_Score_Baseline -0.731710573
## UPDRS_Part_III_Summary_Score_Month_03 -0.105652738
## UPDRS_Part_III_Summary_Score_Month_06 -0.320934255
## UPDRS_Part_III_Summary_Score_Month_09 -0.442358956
## UPDRS_Part_III_Summary_Score_Month_12 -0.700648847
## UPDRS_Part_III_Summary_Score_Month_18 -0.185594310
## UPDRS_Part_III_Summary_Score_Month_24 -0.680253500
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.067378462
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.097126182
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 -0.133066259
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 -0.176082052
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.046120816
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 -0.245177121
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.061094119
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 -0.144972563
## ctrl 0.998487141
## pd -0.799513602
## swedd -0.184367010
## pd
## L_insular_cortex_ComputeArea 0.1142487719
## L_insular_cortex_Volume 0.1167429545
## R_insular_cortex_ComputeArea 0.1437795467
## R_insular_cortex_Volume 0.1485956501
## L_cingulate_gyrus_ComputeArea 0.1212047945
## L_cingulate_gyrus_Volume 0.1236951139
## R_cingulate_gyrus_ComputeArea 0.1155785398
## R_cingulate_gyrus_Volume 0.1217569146
## L_caudate_ComputeArea 0.1022814987
## L_caudate_Volume 0.0972074194
## R_caudate_ComputeArea 0.1126823523
## R_caudate_Volume 0.1074534045
## L_putamen_ComputeArea 0.1373763659
## L_putamen_Volume 0.1369120407
## R_putamen_ComputeArea 0.1288768488
## R_putamen_Volume 0.1272070110
## L_hippocampus_ComputeArea 0.1053175976
## L_hippocampus_Volume 0.1023117649
## R_hippocampus_ComputeArea 0.1269349710
## R_hippocampus_Volume 0.1189525193
## cerebellum_ComputeArea 0.0491768390
## cerebellum_Volume 0.0784505592
## L_fusiform_gyrus_ComputeArea 0.0408074886
## L_fusiform_gyrus_Volume 0.0863398816
## R_fusiform_gyrus_ComputeArea 0.0136745624
## R_fusiform_gyrus_Volume 0.0355092486
## R_fusiform_gyrus_ShapeIndex 0.0696401142
## R_fusiform_gyrus_Curvedness -0.0406071078
## Sex 0.0443472446
## Weight -0.0113089209
## RG_ranked 0.9520834113
## Age 0.0328887890
## chr12_rs34637584_GT 0.0691139183
## chr17_rs11868035_GT -0.0158970092
## chr17_rs11012_GT 0.0116496518
## chr17_rs393152_GT 0.0003671384
## chr17_rs12185268_GT 0.0262682101
## chr17_rs199533_GT 0.0460998376
## UPDRS_Part_I_Summary_Score_Baseline 0.0501950802
## UPDRS_Part_I_Summary_Score_Month_03 0.0113296453
## UPDRS_Part_I_Summary_Score_Month_06 -0.0134116419
## UPDRS_Part_I_Summary_Score_Month_09 -0.0979426089
## UPDRS_Part_I_Summary_Score_Month_12 0.1105806569
## UPDRS_Part_I_Summary_Score_Month_18 0.0702680819
## UPDRS_Part_I_Summary_Score_Month_24 0.1556811137
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.4193387218
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.2180906453
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1595503106
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0940247085
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.4200780983
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.1867053091
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.3834069397
## UPDRS_Part_III_Summary_Score_Baseline 0.6772111700
## UPDRS_Part_III_Summary_Score_Month_03 0.2545775427
## UPDRS_Part_III_Summary_Score_Month_06 0.4009788863
## UPDRS_Part_III_Summary_Score_Month_09 0.4916733115
## UPDRS_Part_III_Summary_Score_Month_12 0.6525446859
## UPDRS_Part_III_Summary_Score_Month_18 0.2614498655
## UPDRS_Part_III_Summary_Score_Month_24 0.6492679706
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline -0.0729859377
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 -0.1805388864
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.0551227705
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.1159578707
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline -0.0058729636
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.1712116568
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 -0.0066215271
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.1214330197
## ctrl -0.7995136021
## pd 0.9984871407
## swedd -0.4402138524
## swedd
## L_insular_cortex_ComputeArea -0.1000616955
## L_insular_cortex_Volume -0.1003982088
## R_insular_cortex_ComputeArea -0.1044919704
## R_insular_cortex_Volume -0.1105528083
## L_cingulate_gyrus_ComputeArea -0.0903640802
## L_cingulate_gyrus_Volume -0.0988295309
## R_cingulate_gyrus_ComputeArea -0.1016858119
## R_cingulate_gyrus_Volume -0.1117462156
## L_caudate_ComputeArea -0.0657366400
## L_caudate_Volume -0.0642973061
## R_caudate_ComputeArea -0.1023545667
## R_caudate_Volume -0.1014827129
## L_putamen_ComputeArea -0.0807843650
## L_putamen_Volume -0.0722075925
## R_putamen_ComputeArea -0.0831903097
## R_putamen_Volume -0.0937852070
## L_hippocampus_ComputeArea -0.0869007552
## L_hippocampus_Volume -0.0950990541
## R_hippocampus_ComputeArea -0.1212299065
## R_hippocampus_Volume -0.1156811999
## cerebellum_ComputeArea -0.0653078218
## cerebellum_Volume -0.1019757542
## L_fusiform_gyrus_ComputeArea 0.0003460741
## L_fusiform_gyrus_Volume -0.0424638797
## R_fusiform_gyrus_ComputeArea -0.0211408953
## R_fusiform_gyrus_Volume -0.0271457922
## R_fusiform_gyrus_ShapeIndex -0.0382170325
## R_fusiform_gyrus_Curvedness 0.0802357934
## Sex 0.0125841788
## Weight 0.0275642989
## RG_ranked -0.1497182003
## Age 0.0216953025
## chr12_rs34637584_GT -0.0304710026
## chr17_rs11868035_GT 0.0354114764
## chr17_rs11012_GT -0.0039812517
## chr17_rs393152_GT -0.0272288437
## chr17_rs12185268_GT -0.0144465025
## chr17_rs199533_GT -0.0076774577
## UPDRS_Part_I_Summary_Score_Baseline 0.2945422676
## UPDRS_Part_I_Summary_Score_Month_03 0.1125925986
## UPDRS_Part_I_Summary_Score_Month_06 0.1358662023
## UPDRS_Part_I_Summary_Score_Month_09 0.1560533200
## UPDRS_Part_I_Summary_Score_Month_12 0.2651979023
## UPDRS_Part_I_Summary_Score_Month_18 0.1509003835
## UPDRS_Part_I_Summary_Score_Month_24 0.1857464343
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Baseline 0.1157550389
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_03 0.0579882082
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_06 0.1078214214
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_09 0.0591006197
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_12 0.1484399746
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_18 0.0719708762
## UPDRS_Part_II_Patient_Questionnaire_Summary_Score_Month_24 0.1600715996
## UPDRS_Part_III_Summary_Score_Baseline -0.0147041741
## UPDRS_Part_III_Summary_Score_Month_03 -0.2593680926
## UPDRS_Part_III_Summary_Score_Month_06 -0.1769930172
## UPDRS_Part_III_Summary_Score_Month_09 -0.1438533891
## UPDRS_Part_III_Summary_Score_Month_12 -0.0207766252
## UPDRS_Part_III_Summary_Score_Month_18 -0.1508619672
## UPDRS_Part_III_Summary_Score_Month_24 -0.0459602337
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Baseline 0.2207019154
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_06 0.1506720526
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_12 0.1089436828
## X_Assessment_Non.Motor_Epworth_Sleepiness_Scale_Summary_Score_Month_24 0.0735874078
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Baseline 0.0787410807
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_06 0.0864642816
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_12 0.1024046105
## X_Assessment_Non.Motor_Geriatric_Depression_Scale_GDS_Short_Summary_Score_Month_24 0.0179913713
## ctrl -0.1843670102
## pd -0.4402138524
## swedd 0.9984871407
## Only 1 cluster categorized.Report the error rates for both the training and the testing data. What do you find?
knn.tune_train = tune.knn(x= pz_train, y = as.factor(pz_train_label), k = 1:50,
tunecontrol=tune.control(sampling = "fix") , fix=10)
summary(knn.tune_train)
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: fixed training/validation set
##
## - best parameters:
## k
## 3
##
## - best performance: 0.02721088
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.03401361 NA
## 2 2 0.03401361 NA
## 3 3 0.02721088 NA
## 4 4 0.02721088 NA
## 5 5 0.02721088 NA
## 6 6 0.02721088 NA
## 7 7 0.04081633 NA
## 8 8 0.04081633 NA
## 9 9 0.04081633 NA
## 10 10 0.04081633 NA
## 11 11 0.04081633 NA
## 12 12 0.04081633 NA
## 13 13 0.04761905 NA
## 14 14 0.05442177 NA
## 15 15 0.05442177 NA
## 16 16 0.05442177 NA
## 17 17 0.05442177 NA
## 18 18 0.05442177 NA
## 19 19 0.05442177 NA
## 20 20 0.05442177 NA
## 21 21 0.05442177 NA
## 22 22 0.05442177 NA
## 23 23 0.05442177 NA
## 24 24 0.06122449 NA
## 25 25 0.05442177 NA
## 26 26 0.05442177 NA
## 27 27 0.05442177 NA
## 28 28 0.06122449 NA
## 29 29 0.05442177 NA
## 30 30 0.05442177 NA
## 31 31 0.05442177 NA
## 32 32 0.05442177 NA
## 33 33 0.05442177 NA
## 34 34 0.05442177 NA
## 35 35 0.05442177 NA
## 36 36 0.05442177 NA
## 37 37 0.05442177 NA
## 38 38 0.05442177 NA
## 39 39 0.05442177 NA
## 40 40 0.05442177 NA
## 41 41 0.05442177 NA
## 42 42 0.05442177 NA
## 43 43 0.05442177 NA
## 44 44 0.06122449 NA
## 45 45 0.06122449 NA
## 46 46 0.06122449 NA
## 47 47 0.06802721 NA
## 48 48 0.06802721 NA
## 49 49 0.06802721 NA
## 50 50 0.06802721 NA
df <- as.data.frame(cbind(x=knn.tune_train$performance$k, y=knn.tune_train$performance$error))
plot_ly(df, x = ~x, y = ~y, type = "scatter", mode = "markers+lines") %>%
add_segments(x=1, xend=1, y=0.0, yend=0.45, type = "scatter",
line=list(color="gray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=5, xend=5, y=0.0, yend=0.45, type = "scatter",
line=list(color="lightgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
layout(title='PPMI k-NN Prediction (Train) - Error Rate against k',
xaxis=list(title='Number of nearest neighbors (k)'), yaxis=list(title='Classification error'))
knn.tune_test = tune.knn(x= pz_test, y = as.factor(pz_test_label), k = 1:50,
tunecontrol=tune.control(sampling = "fix") , fix=10)
summary(knn.tune_test)
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: fixed training/validation set
##
## - best parameters:
## k
## 1
##
## - best performance: 0.02702703
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.02702703 NA
## 2 2 0.02702703 NA
## 3 3 0.02702703 NA
## 4 4 0.04054054 NA
## 5 5 0.02702703 NA
## 6 6 0.02702703 NA
## 7 7 0.04054054 NA
## 8 8 0.04054054 NA
## 9 9 0.04054054 NA
## 10 10 0.04054054 NA
## 11 11 0.04054054 NA
## 12 12 0.04054054 NA
## 13 13 0.02702703 NA
## 14 14 0.02702703 NA
## 15 15 0.02702703 NA
## 16 16 0.02702703 NA
## 17 17 0.04054054 NA
## 18 18 0.02702703 NA
## 19 19 0.02702703 NA
## 20 20 0.04054054 NA
## 21 21 0.04054054 NA
## 22 22 0.04054054 NA
## 23 23 0.04054054 NA
## 24 24 0.06756757 NA
## 25 25 0.05405405 NA
## 26 26 0.06756757 NA
## 27 27 0.05405405 NA
## 28 28 0.05405405 NA
## 29 29 0.06756757 NA
## 30 30 0.06756757 NA
## 31 31 0.06756757 NA
## 32 32 0.06756757 NA
## 33 33 0.05405405 NA
## 34 34 0.06756757 NA
## 35 35 0.05405405 NA
## 36 36 0.05405405 NA
## 37 37 0.05405405 NA
## 38 38 0.06756757 NA
## 39 39 0.06756757 NA
## 40 40 0.06756757 NA
## 41 41 0.08108108 NA
## 42 42 0.09459459 NA
## 43 43 0.10810811 NA
## 44 44 0.10810811 NA
## 45 45 0.09459459 NA
## 46 46 0.09459459 NA
## 47 47 0.10810811 NA
## 48 48 0.10810811 NA
## 49 49 0.12162162 NA
## 50 50 0.10810811 NA
df <- as.data.frame(cbind(x=knn.tune_test$performance$k, y=knn.tune_test$performance$error))
plot_ly(df, x = ~x, y = ~y, type = "scatter", mode = "markers+lines") %>%
add_segments(x=1, xend=1, y=0.0, yend=0.45, type = "scatter",
line=list(color="gray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=5, xend=5, y=0.0, yend=0.45, type = "scatter",
line=list(color="lightgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
layout(title='PPMI k-NN Prediction (Test) - Error Rate against k',
xaxis=list(title='Number of nearest neighbors (k)'), yaxis=list(title='Classification error'))
### Train data has consistent error rate as k increased while the error rate of Test data is has higher value of error rate in general. Test data increased abruptly after K=40 adter perform consistently. Try the above protocol again but select only columns 1 to 5 as predictors (after deleting the index and ID columns). Now, what about the \(k\) you select and the error rates for each kind of scaled data (original data, normalized data)? Comment on any interesting observations.
ppmi<-read.csv("I:/UBD PB/ZH5102 ML/ass4/05_PPMI_top_UPDRS_Integrated_LongFormat.csv")
ppmi$pd<-ifelse(ppmi$ResearchGroup=="PD", 1, 0)
ppmi<-ppmi[,c(3:7,72)]
cor(ppmi[,-6])
## L_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 1.0000000
## L_insular_cortex_Volume 0.9869107
## R_insular_cortex_ComputeArea 0.9342669
## R_insular_cortex_Volume 0.9223210
## L_cingulate_gyrus_ComputeArea 0.9066181
## L_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.9869107
## L_insular_cortex_Volume 1.0000000
## R_insular_cortex_ComputeArea 0.9312231
## R_insular_cortex_Volume 0.9340757
## L_cingulate_gyrus_ComputeArea 0.9064426
## R_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.9342669
## L_insular_cortex_Volume 0.9312231
## R_insular_cortex_ComputeArea 1.0000000
## R_insular_cortex_Volume 0.9864854
## L_cingulate_gyrus_ComputeArea 0.9198314
## R_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.9223210
## L_insular_cortex_Volume 0.9340757
## R_insular_cortex_ComputeArea 0.9864854
## R_insular_cortex_Volume 1.0000000
## L_cingulate_gyrus_ComputeArea 0.9128562
## L_cingulate_gyrus_ComputeArea
## L_insular_cortex_ComputeArea 0.9066181
## L_insular_cortex_Volume 0.9064426
## R_insular_cortex_ComputeArea 0.9198314
## R_insular_cortex_Volume 0.9128562
## L_cingulate_gyrus_ComputeArea 1.0000000
ggpairs(ppmi, columns = 1:5, ggplot2::aes(colour=as.factor(pd)))
ppmi$pd<-as.integer(ppmi$pd)
pz<- as.data.frame(lapply(ppmi, scale))
set.seed(2023)
sub<-sample(nrow(pz), floor(nrow(pz)*2/3))
pz_train<-pz[sub, ]
pz_test<-pz[-sub, ]
Y<-ifelse (pz$pd < 0.5, "No", "Yes")
pz_train_label<-Y[sub]
pz_test_label<-Y[-sub]
table(pz_train_label)
## pz_train_label
## No Yes
## 148 292
knntuning = tune.knn(x= pz_train, y = as.factor(pz_train_label), k = 1:50)
summary(knntuning) # k=1 not applicable
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: 10-fold cross validation
##
## - best parameters:
## k
## 1
##
## - best performance: 0
##
## - Detailed performance results:
## k error dispersion
## 1 1 0 0
## 2 2 0 0
## 3 3 0 0
## 4 4 0 0
## 5 5 0 0
## 6 6 0 0
## 7 7 0 0
## 8 8 0 0
## 9 9 0 0
## 10 10 0 0
## 11 11 0 0
## 12 12 0 0
## 13 13 0 0
## 14 14 0 0
## 15 15 0 0
## 16 16 0 0
## 17 17 0 0
## 18 18 0 0
## 19 19 0 0
## 20 20 0 0
## 21 21 0 0
## 22 22 0 0
## 23 23 0 0
## 24 24 0 0
## 25 25 0 0
## 26 26 0 0
## 27 27 0 0
## 28 28 0 0
## 29 29 0 0
## 30 30 0 0
## 31 31 0 0
## 32 32 0 0
## 33 33 0 0
## 34 34 0 0
## 35 35 0 0
## 36 36 0 0
## 37 37 0 0
## 38 38 0 0
## 39 39 0 0
## 40 40 0 0
## 41 41 0 0
## 42 42 0 0
## 43 43 0 0
## 44 44 0 0
## 45 45 0 0
## 46 46 0 0
## 47 47 0 0
## 48 48 0 0
## 49 49 0 0
## 50 50 0 0
knn_model <- train(x=pz_train, y=pz_train_label , metric = "ROC", method = "knn", tuneLength = 20, trControl = knnControl)
print(knn_model) # k = 43
## k-Nearest Neighbors
##
## 440 samples
## 6 predictor
## 2 classes: 'No', 'Yes'
##
## No pre-processing
## Resampling: Cross-Validated (10 fold)
## Summary of sample sizes: 397, 396, 396, 395, 396, 396, ...
## Resampling results across tuning parameters:
##
## k ROC Sens Spec
## 5 1 1 1
## 7 1 1 1
## 9 1 1 1
## 11 1 1 1
## 13 1 1 1
## 15 1 1 1
## 17 1 1 1
## 19 1 1 1
## 21 1 1 1
## 23 1 1 1
## 25 1 1 1
## 27 1 1 1
## 29 1 1 1
## 31 1 1 1
## 33 1 1 1
## 35 1 1 1
## 37 1 1 1
## 39 1 1 1
## 41 1 1 1
## 43 1 1 1
##
## ROC was used to select the optimal model using the largest value.
## The final value used for the model was k = 43.
pz_test_pred43 <- knn(train=pz_train, test=pz_test, cl=pz_train_label, prob=T, k=43)
pz_test_predBin43 <- ifelse(attributes(pz_test_pred43)$prob == 1, "No", "Yes")
CT <- CrossTable(x=pz_test_label, y=pz_test_predBin43, prop.chisq = F)
##
##
## Cell Contents
## |-------------------------|
## | N |
## | N / Row Total |
## | N / Col Total |
## | N / Table Total |
## |-------------------------|
##
##
## Total Observations in Table: 221
##
##
## | pz_test_predBin43
## pz_test_label | No | Yes | Row Total |
## --------------|-----------|-----------|-----------|
## No | 76 | 3 | 79 |
## | 0.962 | 0.038 | 0.357 |
## | 0.349 | 1.000 | |
## | 0.344 | 0.014 | |
## --------------|-----------|-----------|-----------|
## Yes | 142 | 0 | 142 |
## | 1.000 | 0.000 | 0.643 |
## | 0.651 | 0.000 | |
## | 0.643 | 0.000 | |
## --------------|-----------|-----------|-----------|
## Column Total | 218 | 3 | 221 |
## | 0.986 | 0.014 | |
## --------------|-----------|-----------|-----------|
##
##
print(paste0("Prediction accuracy of model 'pz_test_pred' (k=43) is ", (CT$prop.tbl[1,1]+CT1$prop.tbl[2,2]) ))
## [1] "Prediction accuracy of model 'pz_test_pred' (k=43) is 0.648239228801889"
mod43_TN <- CT$prop.row[1, 1]
mod43_FP <- CT$prop.row[1, 2]
mod43_FN <- CT$prop.row[2, 1]
mod43_TP <- CT$prop.row[2, 2]
mod43_sensi <- mod43_TN/(mod43_TN+mod43_FP)
mod43_speci <- mod43_TP/(mod43_TP+mod43_FN)
print(paste0("kNN model k=43 Sensitivity=", mod43_sensi))
## [1] "kNN model k=43 Sensitivity=0.962025316455696"
print(paste0("kNN model k=43 Specificity=", mod43_speci))
## [1] "kNN model k=43 Specificity=0"
gmm_clust <- Mclust(pz)
summary(gmm_clust, parameters = TRUE)
## ----------------------------------------------------
## Gaussian finite mixture model fitted by EM algorithm
## ----------------------------------------------------
##
## Mclust VEV (ellipsoidal, equal shape) model with 2 components:
##
## log-likelihood n df BIC ICL
## -371.4151 661 50 -1067.518 -1073.895
##
## Clustering table:
## 1 2
## 308 353
##
## Mixing probabilities:
## 1 2
## 0.4670231 0.5329769
##
## Means:
## [,1] [,2]
## L_insular_cortex_ComputeArea 0.6220802 -0.5451002
## L_insular_cortex_Volume 0.6247205 -0.5474138
## R_insular_cortex_ComputeArea 0.6565830 -0.5753334
## R_insular_cortex_Volume 0.6503967 -0.5699127
## L_cingulate_gyrus_ComputeArea 0.6063131 -0.5312842
## pd 0.7226688 -0.6332413
##
## Variances:
## [,,1]
## L_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.1171544
## L_insular_cortex_Volume 0.1388148
## R_insular_cortex_ComputeArea 0.1065900
## R_insular_cortex_Volume 0.1307602
## L_cingulate_gyrus_ComputeArea 0.1251054
## pd 0.0000000
## L_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.1388148
## L_insular_cortex_Volume 0.1751961
## R_insular_cortex_ComputeArea 0.1268470
## R_insular_cortex_Volume 0.1637437
## L_cingulate_gyrus_ComputeArea 0.1487934
## pd 0.0000000
## R_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 0.1065900
## L_insular_cortex_Volume 0.1268470
## R_insular_cortex_ComputeArea 0.1365914
## R_insular_cortex_Volume 0.1632645
## L_cingulate_gyrus_ComputeArea 0.1179645
## pd 0.0000000
## R_insular_cortex_Volume
## L_insular_cortex_ComputeArea 0.1307602
## L_insular_cortex_Volume 0.1637437
## R_insular_cortex_ComputeArea 0.1632645
## R_insular_cortex_Volume 0.2169759
## L_cingulate_gyrus_ComputeArea 0.1459372
## pd 0.0000000
## L_cingulate_gyrus_ComputeArea pd
## L_insular_cortex_ComputeArea 0.1251054 0.0000000000
## L_insular_cortex_Volume 0.1487934 0.0000000000
## R_insular_cortex_ComputeArea 0.1179645 0.0000000000
## R_insular_cortex_Volume 0.1459372 0.0000000000
## L_cingulate_gyrus_ComputeArea 0.2296633 0.0000000000
## pd 0.0000000 0.0003690069
## [,,2]
## L_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 1.490494
## L_insular_cortex_Volume 1.420801
## R_insular_cortex_ComputeArea 1.231770
## R_insular_cortex_Volume 1.176463
## L_cingulate_gyrus_ComputeArea 1.203296
## pd -0.698225
## L_insular_cortex_Volume
## L_insular_cortex_ComputeArea 1.4208013
## L_insular_cortex_Volume 1.3863118
## R_insular_cortex_ComputeArea 1.1930998
## R_insular_cortex_Volume 1.1583531
## L_cingulate_gyrus_ComputeArea 1.1702884
## pd -0.6945259
## R_insular_cortex_ComputeArea
## L_insular_cortex_ComputeArea 1.2317695
## L_insular_cortex_Volume 1.1930998
## R_insular_cortex_ComputeArea 1.3405068
## R_insular_cortex_Volume 1.2765749
## L_cingulate_gyrus_ComputeArea 1.2586407
## pd -0.6794121
## R_insular_cortex_Volume
## L_insular_cortex_ComputeArea 1.1764634
## L_insular_cortex_Volume 1.1583531
## R_insular_cortex_ComputeArea 1.2765749
## R_insular_cortex_Volume 1.2366622
## L_cingulate_gyrus_ComputeArea 1.2064917
## pd -0.6571546
## L_cingulate_gyrus_ComputeArea pd
## L_insular_cortex_ComputeArea 1.2032960 -0.6982250
## L_insular_cortex_Volume 1.1702884 -0.6945259
## R_insular_cortex_ComputeArea 1.2586407 -0.6794121
## R_insular_cortex_Volume 1.2064917 -0.6571546
## L_cingulate_gyrus_ComputeArea 1.3235443 -0.6566522
## pd -0.6566522 1.2582225
## Categorized into two clusters
knn.tune_train = tune.knn(x= pz_train, y = as.factor(pz_train_label), k = 1:50,
tunecontrol=tune.control(sampling = "fix") , fix=10)
summary(knn.tune_train)
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: fixed training/validation set
##
## - best parameters:
## k
## 1
##
## - best performance: 0
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.000000000 NA
## 2 2 0.000000000 NA
## 3 3 0.000000000 NA
## 4 4 0.000000000 NA
## 5 5 0.000000000 NA
## 6 6 0.000000000 NA
## 7 7 0.000000000 NA
## 8 8 0.000000000 NA
## 9 9 0.000000000 NA
## 10 10 0.000000000 NA
## 11 11 0.000000000 NA
## 12 12 0.000000000 NA
## 13 13 0.000000000 NA
## 14 14 0.000000000 NA
## 15 15 0.000000000 NA
## 16 16 0.000000000 NA
## 17 17 0.000000000 NA
## 18 18 0.000000000 NA
## 19 19 0.000000000 NA
## 20 20 0.000000000 NA
## 21 21 0.000000000 NA
## 22 22 0.000000000 NA
## 23 23 0.000000000 NA
## 24 24 0.000000000 NA
## 25 25 0.000000000 NA
## 26 26 0.000000000 NA
## 27 27 0.000000000 NA
## 28 28 0.000000000 NA
## 29 29 0.000000000 NA
## 30 30 0.000000000 NA
## 31 31 0.000000000 NA
## 32 32 0.000000000 NA
## 33 33 0.000000000 NA
## 34 34 0.000000000 NA
## 35 35 0.000000000 NA
## 36 36 0.000000000 NA
## 37 37 0.000000000 NA
## 38 38 0.000000000 NA
## 39 39 0.000000000 NA
## 40 40 0.000000000 NA
## 41 41 0.000000000 NA
## 42 42 0.000000000 NA
## 43 43 0.000000000 NA
## 44 44 0.000000000 NA
## 45 45 0.000000000 NA
## 46 46 0.000000000 NA
## 47 47 0.000000000 NA
## 48 48 0.000000000 NA
## 49 49 0.000000000 NA
## 50 50 0.006802721 NA
df <- as.data.frame(cbind(x=knn.tune_train$performance$k, y=knn.tune_train$performance$error))
plot_ly(df, x = ~x, y = ~y, type = "scatter", mode = "markers+lines") %>%
add_segments(x=1, xend=1, y=0.0, yend=0.45, type = "scatter",
line=list(color="gray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=5, xend=5, y=0.0, yend=0.45, type = "scatter",
line=list(color="lightgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
layout(title='PPMI k-NN Prediction (Train) - Error Rate against k',
xaxis=list(title='Number of nearest neighbors (k)'), yaxis=list(title='Classification error'))
knn.tune_test = tune.knn(x= pz_test, y = as.factor(pz_test_label), k = 1:50,
tunecontrol=tune.control(sampling = "fix") , fix=10)
summary(knn.tune_test)
##
## Parameter tuning of 'knn.wrapper':
##
## - sampling method: fixed training/validation set
##
## - best parameters:
## k
## 1
##
## - best performance: 0
##
## - Detailed performance results:
## k error dispersion
## 1 1 0.00000000 NA
## 2 2 0.00000000 NA
## 3 3 0.00000000 NA
## 4 4 0.00000000 NA
## 5 5 0.00000000 NA
## 6 6 0.00000000 NA
## 7 7 0.00000000 NA
## 8 8 0.00000000 NA
## 9 9 0.00000000 NA
## 10 10 0.00000000 NA
## 11 11 0.00000000 NA
## 12 12 0.00000000 NA
## 13 13 0.00000000 NA
## 14 14 0.00000000 NA
## 15 15 0.00000000 NA
## 16 16 0.00000000 NA
## 17 17 0.00000000 NA
## 18 18 0.00000000 NA
## 19 19 0.00000000 NA
## 20 20 0.00000000 NA
## 21 21 0.00000000 NA
## 22 22 0.00000000 NA
## 23 23 0.00000000 NA
## 24 24 0.00000000 NA
## 25 25 0.00000000 NA
## 26 26 0.00000000 NA
## 27 27 0.00000000 NA
## 28 28 0.00000000 NA
## 29 29 0.00000000 NA
## 30 30 0.00000000 NA
## 31 31 0.00000000 NA
## 32 32 0.00000000 NA
## 33 33 0.00000000 NA
## 34 34 0.00000000 NA
## 35 35 0.00000000 NA
## 36 36 0.00000000 NA
## 37 37 0.00000000 NA
## 38 38 0.00000000 NA
## 39 39 0.02702703 NA
## 40 40 0.01351351 NA
## 41 41 0.02702703 NA
## 42 42 0.04054054 NA
## 43 43 0.04054054 NA
## 44 44 0.02702703 NA
## 45 45 0.02702703 NA
## 46 46 0.06756757 NA
## 47 47 0.08108108 NA
## 48 48 0.10810811 NA
## 49 49 0.09459459 NA
## 50 50 0.10810811 NA
df <- as.data.frame(cbind(x=knn.tune_test$performance$k, y=knn.tune_test$performance$error))
plot_ly(df, x = ~x, y = ~y, type = "scatter", mode = "markers+lines") %>%
add_segments(x=1, xend=1, y=0.0, yend=0.45, type = "scatter",
line=list(color="gray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
add_segments(x=5, xend=5, y=0.0, yend=0.45, type = "scatter",
line=list(color="lightgray", width = 2, dash = 'dot'), mode = "lines", showlegend=FALSE) %>%
layout(title='PPMI k-NN Prediction (Test) - Error Rate against k',
xaxis=list(title='Number of nearest neighbors (k)'), yaxis=list(title='Classification error'))
## Train and Test data are consistently low at 0 but Test data has an increasing error rate after it reaches K = 39.
### Accuracy is lower for high dimensional data. Low dimensional data has extreme value of very high specificty and very low sensitivity when compared to high dimensional data. Low dimensional data able to classify into 2 clusters whereas high dimensional only allow 1 cluster. Error rate in general are lower in low dimensional data than in high dimensional data and the increasing trend of test data for both dimensions are similar.